Header Logo

SHAJI CHACKO

TitleInstructor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES
Houston, TX 77030
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rudar M, Suryawan A, Nguyen HV, Chacko SK, Vonderohe C, Stoll B, Burrin DG, Fiorotto ML, Davis TA, Rudar M, Suryawan A, Nguyen HV, Chacko SK, Vonderohe C, Stoll B, Burrin DG, Fiorotto ML, Davis TA. Pulsatile Leucine Administration during Continuous Enteral Feeding Enhances Skeletal Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis in a Preterm Piglet Model. J Nutr. 2024 02; 154(2):505-515. PMID: 38141773; PMCID: PMC10900192.
      Citations:    Fields:    Translation:HumansAnimals
    2. Quaye E, Chacko S, Startzell M, Brown RJ, Quaye E, Chacko S, Startzell M, Brown RJ. Leptin Decreases Gluconeogenesis and Gluconeogenic Substrate Availability in Patients With Lipodystrophy. J Clin Endocrinol Metab. 2023 Dec 21; 109(1):e209-e215. PMID: 37515588; PMCID: PMC10735288.
      Citations:    Fields:    Translation:HumansCells
    3. Dietsche KB, Magge SN, Dixon SA, Davis FS, Krenek A, Chowdhury A, Mabundo L, Stagliano M, Courville AB, Yang S, Turner S, Cai H, Kasturi K, Sherman AS, Ha J, Shouppe E, Walter M, Walter PJ, Chen KY, Brychta RJ, Peer C, Zeng Y, Figg W, Cogen F, Estrada DE, Chacko S, Chung ST. Glycemia and Gluconeogenesis with Metformin and Liraglutide: A Randomized Trial in Youth-onset Type 2 Diabetes. J Clin Endocrinol Metab. 2023 Nov 15. PMID: 37967247.
      Citations:    Fields:    
    4. Zhong S, Cochran BJ, Sem KP, van Dijk TH, Peng J, Tan LJ, Hartimath SV, Ramasamy B, Cheng P, Groen AK, Kuipers F, Goggi JL, Drum C, van Dam RM, Tan RS, Rye KA, Hayden MR, Cheng CY, Chacko S, Flannick J, Sim X, Tan HC, Singaraja RR, Ch?vre R, Casta?o Mayan D, Corlian? M. Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans. J Clin Invest. 2022 11 01; 132(21). PMID: 36107630; PMCID: PMC9621133.
      Citations:    
    5. Rudar M, Suryawan A, Nguyen HV, Chacko SK, Vonderohe C, Stoll B, Burrin DG, Fiorotto ML, Davis TA. Regulation of skeletal muscle protein synthesis in the preterm pig by intermittent leucine pulses during continuous parenteral feeding. JPEN J Parenter Enteral Nutr. 2023 02; 47(2):276-286. PMID: 36128996; PMCID: PMC10621874.
      Citations:    
    6. Tan HC, Hsu JW, Tai ES, Chacko S, Wu V, Lee CF, Kovalik JP, Jahoor F. De Novo Glycine Synthesis Is Reduced in Adults With Morbid Obesity and Increases Following Bariatric Surgery. Front Endocrinol (Lausanne). 2022; 13:900343. PMID: 35757406; PMCID: PMC9219591.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    7. Gannon AL, Chacko SK, Didelija IC, Marini JC, Blesson CS. Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model. J Vis Exp. 2022 03 05; (181). PMID: 35312673.
      Citations:    Fields:    Translation:Animals
    8. Vonderohe C, Guthrie G, Stoll B, Chacko S, Dawson H, Burrin DG. Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs. Am J Physiol Gastrointest Liver Physiol. 2022 01 01; 322(1):G117-G133. PMID: 34851728; PMCID: PMC8742725.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    9. Quaye E, Chacko S, Chung ST, Brychta RJ, Chen KY, Brown RJ. Energy expenditure due to gluconeogenesis in pathological conditions of insulin resistance. Am J Physiol Endocrinol Metab. 2021 12 01; 321(6):E795-E801. PMID: 34693755; PMCID: PMC8714967.
      Citations: 1     Fields:    Translation:HumansCells
    10. Guthrie G, Stoll B, Chacko S, Mohammad M, Style C, Verla M, Olutoye O, Schady D, Lauridsen C, Tataryn N, Burrin D. Depletion and enrichment of phytosterols in soybean oil lipid emulsions directly associate with serum markers of cholestasis in preterm parenteral nutrition-fed pigs. JPEN J Parenter Enteral Nutr. 2022 01; 46(1):160-171. PMID: 33581699; PMCID: PMC8361868.
      Citations:    Fields:    Translation:HumansAnimals
    11. Kumar P, Liu C, Hsu JW, Chacko S, Minard C, Jahoor F, Sekhar RV. Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial. Clin Transl Med. 2021 03; 11(3):e372. PMID: 33783984; PMCID: PMC8002905.
      Citations: 11     Fields:    Translation:HumansCells
    12. Tan HC, Hsu JW, Kovalik JP, Eng A, Chan WH, Khoo CM, Tai ES, Chacko S, Jahoor F. Branched-Chain Amino Acid Oxidation Is Elevated in Adults with Morbid Obesity and Decreases Significantly after Sleeve Gastrectomy. J Nutr. 2020 12 10; 150(12):3180-3189. PMID: 33097955.
      Citations: 4     Fields:    Translation:HumansCells
    13. Cade WT, Bohnert KL, Bittel AJ, Chacko SJ, Patterson BW, Pacak CA, Byrne BJ, Vernon HJ, Reeds DN. Arginine kinetics are altered in a pilot sample of adolescents and young adults with Barth syndrome. Mol Genet Metab Rep. 2020 Dec; 25:100675. PMID: 33204638; PMCID: PMC7649643.
      Citations: 1     
    14. Kumar P, Liu C, Suliburk JW, Minard CG, Muthupillai R, Chacko S, Hsu JW, Jahoor F, Sekhar RV. Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial. Biomedicines. 2020 Sep 30; 8(10). PMID: 33007928; PMCID: PMC7601820.
      Citations: 4     
    15. Cravalho CKL, Meyers AG, Mabundo LS, Courville A, Yang S, Cai H, Dai Y, Walter M, Walter PJ, Sharma S, Chacko S, Cogen F, Magge SN, Haymond MW, Chung ST. Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes. Diabetologia. 2020 10; 63(10):2194-2204. PMID: 32728891.
      Citations: 2     Fields:    Translation:HumansCells
    16. Baykal AP, Parks EJ, Shamburek R, Syed-Abdul MM, Chacko S, Cochran E, Startzell M, Gharib AM, Ouwerkerk R, Abd-Elmoniem KZ, Walter PJ, Walter M, Muniyappa R, Chung ST, Brown RJ. Leptin decreases de novo lipogenesis in patients with lipodystrophy. JCI Insight. 2020 07 23; 5(14). PMID: 32573497; PMCID: PMC7453896.
      Citations: 13     Fields:    Translation:HumansCells
    17. Sekizkardes H, Chung ST, Chacko S, Haymond MW, Startzell M, Walter M, Walter PJ, Lightbourne M, Brown RJ. Free fatty acid processing diverges in human pathologic insulin resistance conditions. J Clin Invest. 2020 07 01; 130(7):3592-3602. PMID: 32191645; PMCID: PMC7324196.
      Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
    18. Hasek LY, Avery SE, Chacko SK, Fraley JK, Vohra FA, Quezada-Calvillo R, Nichols BL, Hamaker BR. Conditioning with slowly digestible starch diets in mice reduces jejunal a-glucosidase activity and glucogenesis from a digestible starch feeding. Nutrition. 2020 10; 78:110857. PMID: 32599415.
      Citations:    Fields:    Translation:Animals
    19. Call L, Molina T, Stoll B, Guthrie G, Chacko S, Plat J, Robinson J, Lin S, Vonderohe C, Mohammad M, Kunichoff D, Cruz S, Lau P, Premkumar M, Nielsen J, Fang Z, Olutoye O, Thymann T, Britton R, Sangild P, Burrin D. Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs. J Lipid Res. 2020 07; 61(7):1038-1051. PMID: 32350078; PMCID: PMC7328048.
      Citations: 6     Fields:    Translation:Animals
    20. Guthrie G, Stoll B, Chacko S, Lauridsen C, Plat J, Burrin D. Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets. Am J Physiol Gastrointest Liver Physiol. 2020 01 01; 318(1):G41-G52. PMID: 31604032; PMCID: PMC6985848.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Blesson CS, Schutt A, Chacko S, Marini JC, Mathew PR, Tanchico D, Balakrishnan M, Yallampalli C. Sex Dependent Dysregulation of Hepatic Glucose Production in Lean Type 2 Diabetic Rats. Front Endocrinol (Lausanne). 2019; 10:538. PMID: 31447783; PMCID: PMC6691354.
      Citations: 4     Fields:    
    22. Cade WT, Bohnert KL, Peterson LR, Patterson BW, Bittel AJ, Okunade AL, de Las Fuentes L, Steger-May K, Bashir A, Schweitzer GG, Chacko SK, Wanders RJ, Pacak CA, Byrne BJ, Reeds DN. Blunted fat oxidation upon submaximal exercise is partially compensated by enhanced glucose metabolism in children, adolescents, and young adults with Barth syndrome. J Inherit Metab Dis. 2019 05; 42(3):480-493. PMID: 30924938; PMCID: PMC6483838.
      Citations: 12     Fields:    Translation:HumansCells
    23. Tan HC, Hsu JW, Khoo CM, Tai ES, Yu S, Chacko S, Lai OF, Jahoor F. Alterations in branched-chain amino acid kinetics in nonobese but insulin-resistant Asian men. Am J Clin Nutr. 2018 12 01; 108(6):1220-1228. PMID: 30358799.
      Citations: 3     Fields:    Translation:HumansCells
    24. Chung ST, Courville AB, Onuzuruike AU, Galvan-De La Cruz M, Mabundo LS, DuBose CW, Kasturi K, Cai H, Gharib AM, Walter PJ, Garraffo HM, Chacko S, Haymond MW, Sumner AE. Gluconeogenesis and risk for fasting hyperglycemia in Black and White women. JCI Insight. 2018 09 20; 3(18). PMID: 30232289; PMCID: PMC6237227.
      Citations: 10     Fields:    Translation:HumansCells
    25. Tan HC, Yew TW, Chacko S, Tai ES, Kovalik JP, Ching J, Myo Thant S, Khoo CM. Comprehensive assessment of insulin resistance in non-obese Asian Indian and Chinese men. J Diabetes Investig. 2018 Nov; 9(6):1296-1303. PMID: 29582571; PMCID: PMC6215953.
      Citations:    Fields:    Translation:Humans
    26. Shi X, Chacko S, Li F, Li D, Burrin D, Chan L, Guan X. Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity. Mol Metab. 2017 11; 6(11):1350-1359. PMID: 29107283; PMCID: PMC5681239.
      Citations: 14     Fields:    Translation:AnimalsCells
    27. Avery SE, Quezada-Calvillo R, Kilani SB, Lin AH, Burrin DG, Hodges BE, Chacko SK, Opekun AR, Hindawy ME, Hamaker BR, Oda SI, Nichols BL. Improved Starch Digestion of Sucrase-deficient Shrews Treated With Oral Glucoamylase Enzyme Supplements. J Pediatr Gastroenterol Nutr. 2017 08; 65(2):e35-e42. PMID: 28267073.
      Citations: 1     Fields:    Translation:Animals
    28. Mecham B, Chacko S, Fahey JW, Derry JMJ, Haymond MW, Friend SH, Axelsson AS, Tubbs E, Nenonen HA, Tang Y, Wollheim CB, Wierup N, Mulder H, Rosengren AH. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Sci Transl Med. 2017 06 14; 9(394). PMID: 28615356.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    29. Webster CC, Noakes TD, Chacko SK, Swart J, Kohn TA, Smith JA. Gluconeogenesis during endurance exercise in cyclists habituated to a long-term low carbohydrate high-fat diet. J Physiol. 2016 08 01; 594(15):4389-405. PMID: 26918583; PMCID: PMC4967730.
      Citations: 42     Fields:    Translation:HumansCells
    30. Blesson CS, Schutt AK, Balakrishnan MP, Pautler RG, Pedersen SE, Sarkar P, Gonzales D, Zhu G, Marini JC, Chacko SK, Yallampalli U, Yallampalli C. Novel lean type 2 diabetic rat model using gestational low-protein programming. Am J Obstet Gynecol. 2016 Apr; 214(4):540.e1-540.e7. PMID: 26874300; PMCID: PMC4808600.
      Citations: 7     Fields:    Translation:Animals
    31. Nichols BL, Diaz-Sotomayor M, Avery SE, Chacko SK, Hadsell DL, Baker SS, Hamaker BR, Yan LK, Lin HM, Quezada-Calvillo R. Milk glucosidase activity enables suckled pup starch digestion. Mol Cell Pediatr. 2016 Dec; 3(1):4. PMID: 26830109; PMCID: PMC4735098.
      Citations: 2     
    32. Hsu JW, Thame MM, Gibson R, Baker TM, Tang GJ, Chacko SK, Jackson AA, Jahoor F. Unlike pregnant adult women, pregnant adolescent girls cannot maintain glycine flux during late pregnancy because of decreased synthesis from serine. Br J Nutr. 2016 Mar 14; 115(5):759-63. PMID: 26785702.
      Citations: 1     Fields:    Translation:Humans
    33. Chung ST, Chacko SK, Sunehag AL, Haymond MW. Measurements of Gluconeogenesis and Glycogenolysis: A Methodological Review. Diabetes. 2015 Dec; 64(12):3996-4010. PMID: 26604176; PMCID: PMC4657587.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    34. Ng K, Stoll B, Chacko S, Saenz de Pipaon M, Lauridsen C, Gray M, Squires EJ, Marini J, Zamora IJ, Olutoye OO, Burrin DG. Vitamin E in New-Generation Lipid Emulsions Protects Against Parenteral Nutrition-Associated Liver Disease in Parenteral Nutrition-Fed Preterm Pigs. JPEN J Parenter Enteral Nutr. 2016 07; 40(5):656-71. PMID: 25596209; PMCID: PMC4504844.
      Citations: 32     Fields:    Translation:HumansAnimals
    35. Chung ST, Hsia DS, Chacko SK, Rodriguez LM, Haymond MW. Increased gluconeogenesis in youth with newly diagnosed type 2 diabetes. Diabetologia. 2015 Mar; 58(3):596-603. PMID: 25447079; PMCID: PMC4323952.
      Citations: 17     Fields:    Translation:HumansCells
    36. Vlaardingerbroek H, Ng K, Stoll B, Benight N, Chacko S, Kluijtmans LA, Kulik W, Squires EJ, Olutoye O, Schady D, Finegold ML, van Goudoever JB, Burrin DG. New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs. J Lipid Res. 2014 Mar; 55(3):466-77. PMID: 24478031; PMCID: PMC3934731.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    37. Quezada-Calvillo R, Avery SE, Chacko SK, Yan LK, Lin AH, Ao ZH, Hamaker BR, Nichols BL, Diaz-Sotomayor M. Maltase-glucoamylase modulates gluconeogenesis and sucrase-isomaltase dominates starch digestion glucogenesis. J Pediatr Gastroenterol Nutr. 2013 Dec; 57(6):704-12. PMID: 23838818.
      Citations: 14     Fields:    Translation:AnimalsCells
    38. de Betue CT, Verbruggen SC, Schierbeek H, Chacko SK, Bogers AJ, van Goudoever JB, Joosten KF. Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgery? a randomized controlled crossover study. Crit Care. 2012 Oct 02; 16(5):R176. PMID: 23031354; PMCID: PMC3682276.
      Citations: 2     Fields:    Translation:Humans
    39. Haymond MW, Sun Y, Marini JC, Sauer PJ, Ma X, Sunehag AL, Chacko SK. Effect of ghrelin on glucose regulation in mice. Am J Physiol Endocrinol Metab. 2012 May 15; 302(9):E1055-62. PMID: 22338071.
      Citations: 14     Fields:    Translation:AnimalsCells
    40. Verbruggen SC, de Betue CT, Schierbeek H, Chacko S, van Adrichem LN, Verhoeven J, van Goudoever JB, Joosten KF. Reducing glucose infusion safely prevents hyperglycemia in post-surgical children. Clin Nutr. 2011 Dec; 30(6):786-92. PMID: 21719165.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    41. Benight NM, Stoll B, Chacko S, da Silva VR, Marini JC, Gregory JF, Stabler SP, Burrin DG. B-vitamin deficiency is protective against DSS-induced colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G249-59. PMID: 21596995; PMCID: PMC3154603.
      Citations: 12     Fields:    Translation:Animals
    42. Chacko SK, Ordonez J, Sauer PJ, Sunehag AL. Gluconeogenesis is not regulated by either glucose or insulin in extremely low birth weight infants receiving total parenteral nutrition. J Pediatr. 2011 Jun; 158(6):891-6. PMID: 21324479; PMCID: PMC3095705.
      Citations: 15     Fields:    Translation:HumansCells
    43. Chacko SK, Sunehag AL. Gluconeogenesis continues in premature infants receiving total parenteral nutrition. Arch Dis Child Fetal Neonatal Ed. 2010 Nov; 95(6):F413-8. PMID: 20682577.
      Citations: 13     Fields:    Translation:HumansCells
    44. Verbruggen S, Sy J, Gordon WE, Hsu J, Wu M, Chacko S, Zurakowski D, Burrin D, Castillo L. Ontogeny of methionine utilization and splanchnic uptake in critically ill children. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1046-55. PMID: 19724018; PMCID: PMC2781350.
      Citations:    Fields:    Translation:HumansCells
    45. Mohammad MA, Sunehag AL, Chacko SK, Pontius AS, Maningat PD, Haymond MW. Mechanisms to conserve glucose in lactating women during a 42-h fast. Am J Physiol Endocrinol Metab. 2009 Oct; 297(4):E879-88. PMID: 19654284; PMCID: PMC2763788.
      Citations: 15     Fields:    Translation:HumansCells
    46. Bauchart-Thevret C, Stoll B, Chacko S, Burrin DG. Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs. Am J Physiol Endocrinol Metab. 2009 Jun; 296(6):E1239-50. PMID: 19293331; PMCID: PMC2692405.
      Citations: 38     Fields:    Translation:AnimalsCells
    47. Chacko SK, Sunehag AL, Sharma S, Sauer PJ, Haymond MW. Measurement of gluconeogenesis using glucose fragments and mass spectrometry after ingestion of deuterium oxide. J Appl Physiol (1985). 2008 Apr; 104(4):944-51. PMID: 18187615.
      Citations: 17     Fields:    Translation:HumansCells
    48. Riedijk MA, Stoll B, Chacko S, Schierbeek H, Sunehag AL, van Goudoever JB, Burrin DG. Methionine transmethylation and transsulfuration in the piglet gastrointestinal tract. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3408-13. PMID: 17360659; PMCID: PMC1805557.
      Citations: 31     Fields:    Translation:AnimalsCells
    49. Hertel PM, Chacko SK, Pal S, Sunehag AL, Haymond MW. Subcutaneous infusion and capillary "finger stick" sampling of stable isotope tracer in metabolic studies. Pediatr Res. 2006 Nov; 60(5):597-601. PMID: 16988196.
      Citations:    Fields:    Translation:Humans
    CHACKO's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (270)
    Explore
    _
    Co-Authors (30)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _