Suppressor of Cytokine Signaling 1 Protein
"Suppressor of Cytokine Signaling 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.
| Descriptor ID |
D000071222
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| MeSH Number(s) |
D12.644.360.024.374.500 D12.776.157.057.249.500 D12.776.476.024.437.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling 1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling 1 Protein".
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling 1 Protein" by people in this website by year, and whether "Suppressor of Cytokine Signaling 1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Suppressor of Cytokine Signaling 1 Protein" by people in Profiles.
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Aberrant expression of SOCS impairs the anti-leishmanial immune response. Cytokine. 2024 02; 174:156461.
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Phenotypic Variability of SOCS1 Haploinsufficiency. J Clin Immunol. 2023 07; 43(5):902-906.
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Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature. 2020 07; 583(7814):90-95.
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SOCS-1 rescues IL-1?-mediated suppression of epithelial sodium channel in mouse lung epithelial cells via ASK-1. Oncotarget. 2016 May 17; 7(20):29081-91.
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Axl modulates immune activation of smooth muscle cells in vein graft remodeling. Am J Physiol Heart Circ Physiol. 2015 Sep 15; 309(6):H1048-58.
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Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice. Gene Ther. 2015 Nov; 22(11):876-82.
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Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol. 2012 May; 13(5):481-90.
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Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes. Genes Immun. 2012 Jun; 13(4):328-35.
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Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res. 2011 Jul 15; 71(14):4932-43.
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Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Res. 2011 May; 21(5):754-69.