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STEPHANIE SISLEY

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES
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    R21HD106345     (SISLEY, STEPHANIE RENEE)Aug 26, 2022 - Jul 31, 2024
    NIH
    REFINING METRICS OF FOOD BEHAVIOR IN SMITH-MAGENIS SYNDROME
    Role: Principal Investigator
    R01DK128117     (SISLEY, STEPHANIE RENEE)Apr 5, 2022 - Mar 31, 2027
    NIH
    Brain VDR Regulate Glucose Balance
    Role: Principal Investigator
    1-17-JDF-037     (Stephanie Sisley)Jan 1, 2017 - Jun 30, 2021
    American Diabetes Association
    Brain vitamin D receptor mediation of glucose homeostasis
    Role Description: The goal of this study is to determine the role of vitamin D and it's receptor within the paraventricular hypothalamus of the brain on blood sugar control.
    Role: Principle Investigator
    K08DK106447     (SISLEY, STEPHANIE RENEE)Sep 1, 2016 - Dec 31, 2016
    NIH
    Mechanisms of CNS Vitamin D Receptor in Weight Regulation
    Role: Principal Investigator
    F32DK091077     (SISLEY, STEPHANIE RENEE)Jul 1, 2011 - Jul 31, 2013
    NIH
    CNS NFkappaB Regulation of Glucose Homeostasis
    Role: Principal Investigator
         (Dennis Bier)
    United States Department of Agriculture
    Research and research education to improve the nutrition of infants, children, adolescents and pregnant and lactating women
    Role Description: he mission of the Children's Nutrition Research Center (CNRC) is to conduct research that will lead to a definition of the nutritional requirements needed to ensure health in children from conception through adolescence, and in pregnant and lactating women. To accomplish this mission, the CNRC maintains these research areas: a. Nutritional Metabolism in Mothers, Infants and Children b. Pediatric Clinical Nutrition c. Childhood Obesity Prevention d. Developmental Determinants of Obesity in Infants and Children e. Molecular, Cellular and Regulatory aspects of Nutrition during Development This research is to be accomplished over a multi-year period as resources are available via a specific cooperative agreement.
    Role: Co-investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ryder JR, Jenkins TM, Xie C, Courcoulas AP, Harmon CM, Helmrath MA, Sisley S, Michalsky MP, Brandt M, Inge TH. Ten-Year Outcomes after Bariatric Surgery in Adolescents. N Engl J Med. 2024 Oct 31; 391(17):1656-1658. PMID: 39476348.
      Citations:    Fields:    
    2. Calarge C, Amushie C, Dinh S, Mills JA, Devaraj S, Barba-Villalobos G, Nguyen J, Garcia JM, Sisley S, Bacha F, Zemel B. Fluoxetine and Sertraline Inhibit Height Growth and Growth Hormone Signaling During Puberty. J Clin Psychopharmacol. 2024 Oct 14. PMID: 39392873.
      Citations:    Fields:    
    3. Lazareva J, Sisley SR, Brady SM, Smith ACM, Elsea SH, Pomeroy JJ, Roth CL, Sprague JE, Wabitsch M, Garrison J, Yanovski JA. Investigation of setmelanotide, an MC4R agonist, for obesity in individuals with Smith-Magenis syndrome. Obes Res Clin Pract. 2024 Jul-Aug; 18(4):301-307. PMID: 38987029; PMCID: PMC11427144.
      Citations:    Fields:    Translation:Humans
    4. Baumert BO, Maretti-Mira AC, Li Z, Stratakis N, Zhao Y, Walker DI, Wang H, Fischer FC, Jia Q, Valvi D, Bartell SM, Chen C, Inge T, Ryder J, Jenkins T, Sisley S, Xanthakos S, Kohli R, Rock S, Eckel SP, La Merrill MA, Aung MM, Salomon MP, McConnell R, Goodrich J, Conti DV, Golden-Mason L, Chatzi L. PFHpA alters lipid metabolism and increases the risk of metabolic dysfunction-associated steatotic liver disease in youth-a translational research framework. medRxiv. 2024 Jul 03. PMID: 39006440; PMCID: PMC11245066.
      Citations:    
    5. Li Y, Baumert BO, Stratakis N, Goodrich JA, Wu H, Liu SH, Wang H, Beglarian E, Bartell SM, Eckel SP, Walker D, Valvi D, La Merrill MA, Inge TH, Jenkins T, Ryder JR, Sisley S, Kohli R, Xanthakos SA, Vafeiadi M, Margetaki A, Roumeliotaki T, Aung M, McConnell R, Baccarelli A, Conti D, Chatzi L, Wu H, Liu SH, Xanthakos SA. Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children. Environ Res. 2024 Oct 15; 259:119496. PMID: 38936497.
      Citations:    Fields:    Translation:HumansPHPublic Health
    6. Elatrash C, Shi J, Wilson T, Elsea SH, Sisley S. Blind to the perils of pursuing food: Behaviors of individuals with Smith-Magenis Syndrome. Genet Med Open. 2024; 2. PMID: 39119119; PMCID: PMC11309085.
      Citations: 1     
    7. Baumert BO, Eckel SP, Goodrich JA, Li Z, Stratakis N, Walker DI, Zhao Y, Fischer FC, Bartell S, Valvi D, Lin X, Fuentes ZC, Inge T, Ryder J, Jenkins T, Kohli R, Sisley S, Xanthakos S, Rock S, La Merrill MA, McConnell R, Conti DV, Chatzi L. Changes in plasma concentrations of per- and Polyfluoroalkyl substances after bariatric surgery in adolescents from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. Sci Total Environ. 2024 Jun 20; 930:172840. PMID: 38685432; PMCID: PMC11103488.
      Citations:    Fields:    Translation:HumansPHPublic Health
    8. Rubbo B, Li Z, Tachachartvanich P, Baumert BO, Wang H, Pan S, Rock S, Ryder JR, Jenkins T, Sisley S, Lin X, Bartell S, Inge TH, Xanthakos S, McNeil B, Robuck AR, La Merrill MA, Walker DI, Conti DV, McConnell R, Eckel SP, Chatzi L. Exposure to 4,4'-DDE in visceral adipose tissue and weight loss in adolescents from the Teen-LABS cohort. Obesity (Silver Spring). 2024 05; 32(5):1023-1032. PMID: 38515392; PMCID: PMC11039378.
      Citations:    Fields:    Translation:HumansCells
    9. Kubota-Mishra E, Huang X, Minard CG, Astudillo M, Refaey A, Montes G, Sisley S, Ram N, Winter WE, Naylor RN, Balasubramanyam A, Redondo MJ, Tosur M, RADIANT Study Group. High Prevalence of A-?+ Ketosis-Prone Diabetes in Children with Type 2 Diabetes and Diabetic Ketoacidosis at Diagnosis: Evidence from the Rare and Atypical Diabetes Network (RADIANT). Pediatr Diabetes. 2024; 2024. PMID: 38765897; PMCID: PMC11100136.
      Citations:    Fields:    Translation:HumansCells
    10. Li YJ, Baumert BO, Stratakis N, Goodrich JA, Wu HT, He JX, Zhao YQ, Aung MT, Wang HX, Eckel SP, Walker DI, Valvi D, La Merrill MA, Ryder JR, Inge TH, Jenkins T, Sisley S, Kohli R, Xanthakos SA, Baccarelli AA, McConnell R, Conti DV, Chatzi L. Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity. World J Gastroenterol. 2024 Jan 28; 30(4):332-345. PMID: 38313232; PMCID: PMC10835537.
      Citations: 2     Fields:    Translation:Humans
    11. Wasserman H, Jenkins T, Inge T, Ryder J, Michalsky M, Sisley S, Xie C, Kalkwarf HJ. Bone mineral density in young adults 5 to 11 years after adolescent metabolic and bariatric surgery for severe obesity compared to peers. Int J Obes (Lond). 2024 Apr; 48(4):575-583. PMID: 38177697.
      Citations:    Fields:    Translation:Humans
    12. Sisley S. Blurring boundaries. Science. 2023 Dec; 382(6674):1082. PMID: 38033069.
      Citations:    Fields:    
    13. Sanyal S, Calarge C, Rowan PJ, Aparasu RR, Abughosh S, Sisley S, Chen H. Adherence to Recommended Metabolic Monitoring of Children and Adolescents Taking Second-Generation Antipsychotics. Psychiatr Serv. 2024 Apr 01; 75(4):342-348. PMID: 37789728.
      Citations:    Fields:    Translation:Humans
    14. Baumert BO, Fischer FC, Nielsen F, Grandjean P, Bartell S, Stratakis N, Walker DI, Valvi D, Kohli R, Inge T, Ryder J, Jenkins T, Sisley S, Xanthakos S, Rock S, La Merrill MA, Conti D, McConnell R, Chatzi L. Paired Liver:Plasma PFAS Concentration Ratios from Adolescents in the Teen-LABS Study and Derivation of Empirical and Mass Balance Models to Predict and Explain Liver PFAS Accumulation. Environ Sci Technol. 2023 10 10; 57(40):14817-14826. PMID: 37756184; PMCID: PMC10591710.
      Citations: 1     Fields:    Translation:HumansAnimals
    15. Xie C, Wasserman H, Jenkins T, Inge T, Ryder J, Michalsky M, Sisley S, Kalkwarf H. Bone mineral density 5 to 11 years after metabolic and bariatric surgery in adolescents with severe obesity compared to peers. Res Sq. 2023 Sep 21. PMID: 37790519; PMCID: PMC10543495.
      Citations:    
    16. RADIANT Study Group. The Rare and Atypical Diabetes Network (RADIANT) Study: Design and Early Results. Diabetes Care. 2023 06 01; 46(6):1265-1270. PMID: 37104866; PMCID: PMC10234756.
      Citations:    Fields:    Translation:Humans
    17. DeMello AS, Acorda DE, Thompson D, Allen DL, Aman R, Brandt ML, Sisley S. Growing Up After Adolescent Bariatric Surgery. Clin Nurs Res. 2023 01; 32(1):115-125. PMID: 36169264.
      Citations:    Fields:    Translation:Humans
    18. Nguyen J, Asonye E, Thompson D, Sisley S, Bryant K, Sandhu J. Isolation in a Sea of "Experts": Identifying the Parental Struggles Caring for Children With Early-Onset Obesity. Child Obes. 2023 09; 19(6):408-416. PMID: 36112365.
      Citations:    
    19. Isart FA, Isart-Infante FJ, Heidel ER, Sisley S. Acanthosis Nigricans Is a Strong Predictor of Low Blood Calcidiol Levels in Children and Adolescents. Metab Syndr Relat Disord. 2022 11; 20(9):509-516. PMID: 35834574.
      Citations:    Fields:    
    20. Gandhi AA, Wilson TA, Sisley S, Elsea SH, Foster RH. Relationships between food-related behaviors, obesity, and medication use in individuals with Smith-Magenis syndrome. Res Dev Disabil. 2022 Aug; 127:104257. PMID: 35597045.
      Citations:    Fields:    Translation:Humans
    21. Beck J, da Silva Teixeira S, Harrison K, Phillips G, He Y, Sisley S. Paraventricular Vitamin D Receptors Are Required for Glucose Tolerance in Males but Not Females. Front Endocrinol (Lausanne). 2022; 13:869678. PMID: 35620386; PMCID: PMC9128386.
      Citations:    Fields:    Translation:Animals
    22. Costello E, Rock S, Stratakis N, Eckel SP, Walker DI, Valvi D, Cserbik D, Jenkins T, Xanthakos SA, Kohli R, Sisley S, Vasiliou V, La Merrill MA, Rosen H, Conti DV, McConnell R, Chatzi L. Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis. Environ Health Perspect. 2022 04; 130(4):46001. PMID: 35475652; PMCID: PMC9044977.
      Citations: 2     Fields:    Translation:Humans
    23. Puri K, Adachi I, Bocchini CE, Spinner JA, Denfield SW, Sisley S, Elias BA, Jimenez-Gomez A, Price JF, Dreyer WJ, Choudhry S, Tunuguntla HP. Trends in Body Mass Index and Association With Outcomes in Pediatric Patients on Continuous Flow Ventricular Assist Device Support. ASAIO J. 2022 09 01; 68(9):1182-1190. PMID: 34967787.
      Citations:    Fields:    
    24. Astudillo M, Tosur M, Castillo B, Rafaey A, Siller AF, Nieto J, Sisley S, McKay S, Nella AA, Balasubramanyam A, Bacha F, Redondo MJ. Type 2 diabetes in prepubertal children. Pediatr Diabetes. 2021 11; 22(7):946-950. PMID: 34363430.
      Citations: 5     Fields:    Translation:Humans
    25. Al-Gadi I, Sisley S. Case-Based Curriculum for Pediatric Residents in Diabetes Fundamentals. MedEdPORTAL. 2021 05 27; 17:11157. PMID: 34124348; PMCID: PMC8155076.
      Citations:    Fields:    Translation:Humans
    26. Liu H, He Y, Beck J, da Silva Teixeira S, Harrison K, Xu Y, Sisley S. Defining vitamin D receptor expression in the brain using a novel VDRCre mouse. J Comp Neurol. 2021 06; 529(9):2362-2375. PMID: 33368246; PMCID: PMC8053677.
      Citations: 5     Fields:    Translation:Animals
    27. Redondo MJ, Siller AF, Gu X, Tosur M, Bondy M, Devaraj S, Sisley S. Sex differences in circulating leptin as a marker of adiposity in obese or overweight adolescents with type 1 diabetes. BMJ Open Diabetes Res Care. 2020 10; 8(1). PMID: 33087341; PMCID: PMC7580039.
      Citations:    Translation:Humans
    28. Athanassaki I, Lyons S, DeSalvo D, Hendrix K, Ebenezer S, McCann-Crosby B, Redondo M, Chen MJ, Uysal S, Sisley S. Diabetes Curriculum for Pediatric Endocrine Fellowship Utilizing Modified Team-Based Learning. MedEdPORTAL. 2020 08 13; 16:10948. PMID: 32821810; PMCID: PMC7431187.
      Citations: 2     Fields:    Translation:Humans
    29. Zachary M, Sisley S. The Pediatric Obesity Encounter: Literature and Resources to Help with 4 Common Issues. Curr Nutr Rep. 2020 06; 9(2):94-100. PMID: 32350815.
      Citations: 1     Fields:    Translation:Humans
    30. da Silva Teixeira S, Harrison K, Uzodike M, Rajapakshe K, Coarfa C, He Y, Xu Y, Sisley S. Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects. J Steroid Biochem Mol Biol. 2020 06; 200:105690. PMID: 32408067; PMCID: PMC7397709.
      Citations: 6     Fields:    Translation:AnimalsCells
    31. Horne VE, Bielamowicz K, Nguyen J, Hilsenbeck S, Lindsay H, Sonabend R, Wood AC, Okcu F, Sisley S. Methylphenidate improves weight control in childhood brain tumor survivors with hypothalamic obesity. Pediatr Blood Cancer. 2020 07; 67(7):e28379. PMID: 32383818.
      Citations: 2     Fields:    Translation:Humans
    32. Harrison K, Sisley S. Vitamin D and the paraventricular nucleus: Relevance for type 2 diabetes. J Steroid Biochem Mol Biol. 2018 03; 177:125-128. PMID: 28993246.
      Citations: 1     Fields:    Translation:HumansAnimals
    33. Sisley SR, Arble DM, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA, Chambers AP, Gutierrez-Aguilar R. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 09; 65(9):2732-41. PMID: 27217488; PMCID: PMC5001188.
      Citations: 17     Fields:    Translation:AnimalsCells
    34. Gao H, Sisley S, Yallampalli C. Blunted hypothalamic ghrelin signaling reduces diet intake in rats fed a low-protein diet in late pregnancy. Physiol Rep. 2015 Dec; 3(12). PMID: 26660550; PMCID: PMC4760445.
      Citations: 2     Fields:    
    35. Sandoval D, Sisley SR. Brain GLP-1 and insulin sensitivity. Mol Cell Endocrinol. 2015 Dec 15; 418 Pt 1:27-32. PMID: 25724479; PMCID: PMC4547906.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    36. Sisley S, Smith K, Sandoval DA, Seeley RJ. Differences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats. Peptides. 2014 Aug; 58:1-6. PMID: 24879927; PMCID: PMC4113007.
      Citations: 11     Fields:    Translation:Animals
    37. Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, Seeley RJ. Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. J Clin Invest. 2014 Jun; 124(6):2456-63. PMID: 24762441; PMCID: PMC4038572.
      Citations: 136     Fields:    Translation:Animals
    38. Chambers AP, Smith EP, Begg DP, Grayson BE, Sisley S, Greer T, Sorrell J, Lemmen L, LaSance K, Woods SC, Seeley RJ, D'Alessio DA, Sandoval DA. Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy. Am J Physiol Endocrinol Metab. 2014 Feb 15; 306(4):E424-32. PMID: 24368666; PMCID: PMC3923088.
      Citations: 60     Fields:    Translation:Animals
    39. Heppner KM, Piechowski CL, Ottaway N, Sisley S, Smiley DL, Habegger KM, Pfluger PT, Dimarchi R, Biebermann H, Sandoval DA, Perez-Tilve D, M?ller A, Tsch?p MH. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes. 2014 Jan; 63(1):122-31. PMID: 24062249; PMCID: PMC3868046.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    40. Sisley S, Backeljauw P. Reply: To PMID 23706358. J Pediatr. 2013 Nov; 163(5):1535. PMID: 24011758.
      Citations:    Fields:    Translation:Humans
    41. Sisley S, Sandoval D, Herbach N, Zengin A, Fischereder M, Menhofer D, Stoehr BJ, Stemmer K, Seeley RJ, Bidlingmaier M, Bielohuby M, Wanke R, Tsch?p MH. Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab. 2013 Nov 01; 305(9):E1059-70. PMID: 23982154.
      Citations: 33     Fields:    Translation:AnimalsCells
    42. Sisley S, Trujillo MV, Khoury J, Backeljauw P. Low incidence of pathology detection and high cost of screening in the evaluation of asymptomatic short children. J Pediatr. 2013 Oct; 163(4):1045-51. PMID: 23706358; PMCID: PMC3786014.
      Citations: 24     Fields:    Translation:Humans
    43. Sandoval D, Barrera JG, Stefater MA, Sisley S, Woods SC, D'Alessio DD, Seeley RJ. The anorectic effect of GLP-1 in rats is nutrient dependent. PLoS One. 2012; 7(12):e51870. PMID: 23284795; PMCID: PMC3524167.
      Citations: 16     Fields:    Translation:Animals
    44. Sisley S, Sandoval D. Hypothalamic control of energy and glucose metabolism. Rev Endocr Metab Disord. 2011 Sep; 12(3):219-33. PMID: 21695389.
      Citations: 18     Fields:    Translation:Humans
    45. Chambers AP, Jessen L, Ryan KK, Sisley S, Stefater MA, Gaitonde SG, Sorrell JE, Toure M, Berger J, D'Alessio DA, Woods SC, Seeley RJ, Sandoval DA, Wilson-P?rez HE. Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology. 2011 Sep; 141(3):950-8. PMID: 21699789; PMCID: PMC3163814.
      Citations: 150     Fields:    Translation:Animals
    46. Chambers AP, Stefater MA, Wilson-Perez HE, Jessen L, Sisley S, Ryan KK, Gaitonde S, Sorrell JE, Toure M, D'Alessio DA, Sandoval DA, Seeley RJ, Woods SC, Berger J. Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats. Physiol Behav. 2011 Nov 30; 105(1):120-3. PMID: 21683726; PMCID: PMC3852684.
      Citations: 36     Fields:    Translation:Animals
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