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ROBERT WATERLAND

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics


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    R01DK129265     (WATERLAND, ROBERT A)Aug 24, 2021 - May 31, 2025
    NIH
    Systemic interindividual epigenetic variants in African Americans: Identification, characterization, and prospective associations with obesity
    Role: Principal Investigator
    R01DK125562     (WATERLAND, ROBERT A)Jul 1, 2020 - Mar 31, 2025
    NIH
    Unbiased identification and characterization of mouse metastable epialleles
    Role: Principal Investigator
    R01DK111522     (WATERLAND, ROBERT A)Mar 1, 2017 - Feb 28, 2021
    NIH
    Epigenetic variation at metastable epialleles: Effects on human obesity
    Role: Principal Investigator
    R01DK111831     (SIMERLY, RICHARD B)Mar 1, 2017 - Feb 28, 2021
    NIH
    Epigenetic Mechanisms and Developmental Actions of Leptin in the Hypothalamus
    Role: Co-Principal Investigator
    R21HD087860     (WOOD, ALEXIS CAROLINE)Apr 15, 2016 - Mar 31, 2020
    NIH
    Overcoming Obstacles in Epigenetic Analysis of Human Twins
    Role: Co-Principal Investigator
    R56DK103688     (WATERLAND, ROBERT A)Sep 18, 2015 - Aug 31, 2016
    NIH
    Epigenetic Mechanisms in Developmental Mismatch
    Role: Principal Investigator
    R01DK081557     (WATERLAND, ROBERT A)Aug 1, 2008 - Jun 30, 2014
    NIH
    Epigenetic Mechanisms in Obesity
    Role: Principal Investigator
    K01DK070007     (WATERLAND, ROBERT A)Apr 1, 2005 - Mar 31, 2010
    NIH
    Early Nutritional Influences on Mammalian Epigenetics
    Role: Principal Investigator
    F32DK063781     (WATERLAND, ROBERT A)Sep 1, 2003 - Aug 31, 2006
    NIH
    Early nutritional influences on mammalian epigenetics
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chang WJ, Baker MS, Laritsky E, Gunasekara CJ, Maduranga U, Galliou JC, McFadden JW, Waltemyer JR, Berggren-Thomas B, Tate BN, Zhang H, Rosen BD, Van Tassell CP, Liu GE, Coarfa C, Ren YA, Waterland RA. Systemic interindividual DNA methylation variants in cattle share major hallmarks with those in humans. Genome Biol. 2024 Jul 15; 25(1):185. PMID: 39004763; PMCID: PMC11247883.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Gunasekara CJ, MacKay H, Scott CA, Li S, Laritsky E, Baker MS, Grimm SL, Jun G, Li Y, Chen R, Wiemels JL, Coarfa C, Waterland RA. Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control. Genome Biol. 2023 01 12; 24(1):2. PMID: 36631879; PMCID: PMC9835319.
      Citations: 4     Fields:    Translation:HumansCells
    3. MacKay H, Gunasekara CJ, Yam KY, Srisai D, Yalamanchili HK, Li Y, Chen R, Coarfa C, Waterland RA. Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index. Sci Adv. 2022 09 30; 8(39):eabo3991. PMID: 36170368; PMCID: PMC9519050.
      Citations: 1     Fields:    Translation:HumansAnimals
    4. Candler T, Kessler NJ, Gunasekara CJ, Ward KA, James P, Laritsky E, Baker MS, Dyer R, Elango R, Jeffries D, Waterland RA, Moore SE, Ludgate M, Prentice AM, Silver MJ. DNA methylation at a nutritionally sensitive region of the PAX8 gene is associated with thyroid volume and function in Gambian children. Sci Adv. 2021 Nov 05; 7(45):eabj1561. PMID: 34739318; PMCID: PMC8570597.
      Citations: 3     Fields:    
    5. Gunasekara CJ, Hannon E, MacKay H, Coarfa C, McQuillin A, Clair DS, Mill J, Waterland RA. A machine learning case-control classifier for schizophrenia based on DNA methylation in blood. Transl Psychiatry. 2021 08 03; 11(1):412. PMID: 34341337; PMCID: PMC8329061.
      Citations:    Fields:    Translation:HumansCells
    6. Robinson SL, Zeng X, Guan W, Sundaram R, Mendola P, Putnick DL, Waterland RA, Gunasekara CJ, Kannan K, Gao C, Bell EM, Yeung EH. Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the Upstate KIDS cohort. Environ Res. 2021 03; 194:110668. PMID: 33387539; PMCID: PMC7946760.
      Citations: 3     Fields:    Translation:HumansCells
    7. Momin SR, Senn MK, Buckley S, Buist NRM, Gandhi M, Hair AB, Hughes SO, Hodges KR, Lange WC, Papaioannou MA, Phan M, Waterland RA, Wood AC. Rationale and design of the Baylor Infant Twin Study-A study assessing obesity-related risk factors from infancy. Obes Sci Pract. 2021 Feb; 7(1):63-70. PMID: 33680493; PMCID: PMC7909590.
      Citations: 1     
    8. Scott CA, Duryea JD, MacKay H, Baker MS, Laritsky E, Gunasekara CJ, Coarfa C, Waterland RA. Identification of cell type-specific methylation signals in bulk whole genome bisulfite sequencing data. Genome Biol. 2020 07 01; 21(1):156. PMID: 32605651; PMCID: PMC7329512.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    9. MacKay H, Scott CA, Duryea JD, Baker MS, Laritsky E, Elson AE, Garland T, Fiorotto ML, Chen R, Li Y, Coarfa C, Simerly RB, Waterland RA. DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice. Nat Commun. 2019 12 02; 10(1):5364. PMID: 31792207; PMCID: PMC6889160.
      Citations: 6     Fields:    Translation:AnimalsCells
    10. Gunasekara CJ, Waterland RA. A new era for epigenetic epidemiology. Epigenomics. 2019 11 01; 11(15):1647-1649. PMID: 31729252.
      Citations: 5     Fields:    Translation:HumansCells
    11. Li G, Petkova TD, Laritsky E, Kessler N, Baker MS, Zhu S, Waterland RA. Early postnatal overnutrition accelerates aging-associated epigenetic drift in pancreatic islets. Environ Epigenet. 2019 Jul; 5(3):dvz015. PMID: 31528363; PMCID: PMC6735752.
      Citations: 7     
    12. Ren YA, Monkkonen T, Lewis MT, Bernard DJ, Christian HC, Jorgez CJ, Moore JA, Landua JD, Chin HM, Chen W, Singh S, Kim IS, Zhang XH, Xia Y, Phillips KJ, MacKay H, Waterland RA, Ljungberg MC, Saha PK, Hartig SM, Richards JS, Coll TF. S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. JCI Insight. 2019 07 02; 5. PMID: 31265437; PMCID: PMC6675546.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    13. Gunasekara CJ, Scott CA, Laritsky E, Baker MS, MacKay H, Duryea JD, Kessler NJ, Hellenthal G, Wood AC, Hodges KR, Gandhi M, Hair AB, Silver MJ, Moore SE, Prentice AM, Li Y, Chen R, Coarfa C, Waterland RA. A genomic atlas of systemic interindividual epigenetic variation in humans. Genome Biol. 2019 06 03; 20(1):105. PMID: 31155008; PMCID: PMC6545702.
      Citations: 22     Fields:    Translation:HumansCells
    14. Kessler NJ, Waterland RA, Prentice AM, Silver MJ. Establishment of environmentally sensitive DNA methylation states in the very early human embryo. Sci Adv. 2018 07; 4(7):eaat2624. PMID: 30009262; PMCID: PMC6040841.
      Citations: 21     Fields:    Translation:HumansCells
    15. Van Baak TE, Coarfa C, Fiorito G, Laritsky E, Baker MS, Kessler NJ, Dong J, Duryea JD, Silver MJ, Saffari A, Prentice AM, Moore SE, Ghantous A, Routledge MN, Gong YY, Herceg Z, Vineis P, Severi G, Hopper JL, Southey MC, Giles GG, Milne RL, Waterland RA, Dugu? PA. Epigenetic supersimilarity of monozygotic twin pairs. Genome Biol. 2018 01 09; 19(1):2. PMID: 29310692; PMCID: PMC5759268.
      Citations: 31     Fields:    Translation:HumansCells
    16. Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, Fry R, Issa JP, Kellermayer R, Koturbash I, Kondo Y, Lepeule J, Lima SCS, Marsit CJ, Rakyan V, Saffery R, Taylor JA, Teschendorff AE, Ushijima T, Vineis P, Walker CL, Waterland RA, Wiemels J, Ambatipudi S, Degli Esposti D, Hernandez-Vargas H. Roadmap for investigating epigenome deregulation and environmental origins of cancer. Int J Cancer. 2018 03 01; 142(5):874-882. PMID: 28836271; PMCID: PMC6027626.
      Citations: 24     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    17. MacKay H, Heindel JJ, Ross MG, Waterland RA. Meeting summary: the inaugural meeting of the US DOHaD society. Environ Epigenet. 2017 Jan; 3(1):dvw026. PMID: 29492302; PMCID: PMC5804540.
      Citations:    
    18. Garland T, Cadney MD, Waterland RA. Early-Life Effects on Adult Physical Activity: Concepts, Relevance, and Experimental Approaches. Physiol Biochem Zool. 2017 Jan/Feb; 90(1):1-14. PMID: 28051947; PMCID: PMC6397655.
      Citations: 7     Fields:    Translation:Animals
    19. Waterland RA, Hennig BJ, Silver M, Fulford AJ, Dominguez-Salas P, Moore SE, Prentice AM, K?hnen P, Handke D, Spranger J, Hinney A, Hebebrand J, Heppner FL, Walzer L, Gr?tzinger C, Gromoll J, Wiegand S, Gr?ters A, Krude H. Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity. Cell Metab. 2016 09 13; 24(3):502-509. PMID: 27568547.
      Citations: 37     Fields:    Translation:HumansCells
    20. Estill MS, Bolnick JM, Waterland RA, Bolnick AD, Diamond MP, Krawetz SA. Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of?newborn infants. Fertil Steril. 2016 09 01; 106(3):629-639.e10. PMID: 27288894.
      Citations: 30     Fields:    Translation:HumansCellsPHPublic Health
    21. Sutton EF, Gilmore LA, Dunger DB, Heijmans BT, Hivert MF, Ling C, Martinez JA, Ozanne SE, Simmons RA, Szyf M, Waterland RA, Redman LM, Ravussin E. Developmental programming: State-of-the-science and future directions-Summary from a Pennington Biomedical symposium. Obesity (Silver Spring). 2016 05; 24(5):1018-26. PMID: 27037645; PMCID: PMC4846483.
      Citations: 12     Fields:    Translation:HumansAnimals
    22. Eclarinal JD, Zhu S, Baker MS, Piyarathna DB, Coarfa C, Fiorotto ML, Waterland RA. Maternal exercise during pregnancy promotes physical activity in adult offspring. FASEB J. 2016 07; 30(7):2541-8. PMID: 27033262; PMCID: PMC4904289.
      Citations: 17     Fields:    Translation:Animals
    23. Kessler NJ, Van Baak TE, Baker MS, Laritsky E, Coarfa C, Waterland RA. CpG methylation differences between neurons and glia are highly conserved from mouse to human. Hum Mol Genet. 2016 Jan 15; 25(2):223-32. PMID: 26566671; PMCID: PMC4706111.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    24. Zhu S, Eclarinal J, Baker MS, Li G, Waterland RA. Developmental programming of energy balance regulation: is physical activity more 'programmable' than food intake? Proc Nutr Soc. 2016 Feb; 75(1):73-77. PMID: 26511431.
      Citations: 9     Fields:    
    25. Yu DH, Gadkari M, Zhou Q, Yu S, Gao N, Guan Y, Schady D, Roshan TN, Chen MH, Laritsky E, Ge Z, Wang H, Chen R, Westwater C, Bry L, Waterland RA, Moriarty C, Hwang C, Swennes AG, Moore SR, Shen L. Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome. Genome Biol. 2015 Sep 30; 16:211. PMID: 26420038; PMCID: PMC4589031.
      Citations: 54     Fields:    Translation:AnimalsCells
    26. Silver MJ, Kessler NJ, Hennig BJ, Dominguez-Salas P, Laritsky E, Baker MS, Coarfa C, Hernandez-Vargas H, Castelino JM, Routledge MN, Gong YY, Herceg Z, Lee YS, Lee K, Moore SE, Fulford AJ, Prentice AM, Waterland RA. Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment. Genome Biol. 2015 Jun 11; 16:118. PMID: 26062908; PMCID: PMC4464629.
      Citations: 74     Fields:    Translation:HumansCells
    27. Wahlqvist ML, Krawetz SA, Rizzo NS, Dominguez-Bello MG, Szymanski LM, Barkin S, Yatkine A, Waterland RA, Mennella JA, Desai M, Ross MG, Krebs NF, Young BE, Wardle J, Wrann CD, Kral JG. Early-life influences on obesity: from preconception to adolescence. Ann N Y Acad Sci. 2015 Jul; 1347:1-28. PMID: 26037603; PMCID: PMC4522218.
      Citations: 10     Fields:    Translation:Humans
    28. Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. Integrative analysis of 111 reference human epigenomes. Nature. 2015 Feb 19; 518(7539):317-30. PMID: 25693563; PMCID: PMC4530010.
      Citations: 2568     Fields:    Translation:HumansCells
    29. Yu DH, Waterland RA, Shen L. On the meaning of the word 'epimutation': a comment. Trends Genet. 2015 Jan; 31(1):1. PMID: 25480537.
      Citations:    Fields:    Translation:Animals
    30. Yu DH, Waterland RA, Zhang P, Schady D, Chen MH, Guan Y, Gadkari M, Shen L. Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest. 2014 Sep; 124(9):3708-12. PMID: 25061879; PMCID: PMC4151219.
      Citations: 36     Fields:    Translation:AnimalsCells
    31. Waterland RA. Epigenetic mechanisms affecting regulation of energy balance: many questions, few answers. Annu Rev Nutr. 2014; 34:337-55. PMID: 24850387.
      Citations: 42     Fields:    Translation:HumansAnimals
    32. Dominguez-Salas P, Moore SE, Baker MS, Bergen AW, Cox SE, Dyer RA, Fulford AJ, Guan Y, Laritsky E, Silver MJ, Swan GE, Zeisel SH, Innis SM, Waterland RA, Prentice AM, Hennig BJ. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nat Commun. 2014 Apr 29; 5:3746. PMID: 24781383; PMCID: PMC4015319.
      Citations: 198     Fields:    Translation:HumansCells
    33. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR, Tauber M. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb; 22 Suppl 1:S1-S17. PMID: 24574081; PMCID: PMC4159941.
      Citations: 28     Fields:    Translation:Humans
    34. Kunde-Ramamoorthy G, Coarfa C, Laritsky E, Kessler NJ, Harris RA, Xu M, Chen R, Shen L, Milosavljevic A, Waterland RA. Comparison and quantitative verification of mapping algorithms for whole-genome bisulfite sequencing. Nucleic Acids Res. 2014 Apr; 42(6):e43. PMID: 24391148; PMCID: PMC3973287.
      Citations: 29     Fields:    Translation:HumansCells
    35. Li G, Zhang W, Baker MS, Laritsky E, Mattan-Hung N, Yu D, Kunde-Ramamoorthy G, Simerly RB, Chen R, Shen L, Waterland RA. Major epigenetic development distinguishing neuronal and non-neuronal cells occurs postnatally in the murine hypothalamus. Hum Mol Genet. 2014 Mar 15; 23(6):1579-90. PMID: 24186871; PMCID: PMC3929094.
      Citations: 14     Fields:    Translation:AnimalsCells
    36. Baker MS, Li G, Kohorst JJ, Waterland RA. Fetal growth restriction promotes physical inactivity and obesity in female mice. Int J Obes (Lond). 2015 Jan; 39(1):98-104. PMID: 23924758; PMCID: PMC3872504.
      Citations: 16     Fields:    Translation:AnimalsCells
    37. Dominguez-Salas P, Moore SE, Cole D, da Costa KA, Cox SE, Dyer RA, Fulford AJ, Innis SM, Waterland RA, Zeisel SH, Prentice AM, Hennig BJ. DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. Am J Clin Nutr. 2013 Jun; 97(6):1217-27. PMID: 23576045; PMCID: PMC3652920.
      Citations: 68     Fields:    Translation:HumansCells
    38. Li G, Kohorst JJ, Zhang W, Laritsky E, Kunde-Ramamoorthy G, Baker MS, Fiorotto ML, Waterland RA. Early postnatal nutrition determines adult physical activity and energy expenditure in female mice. Diabetes. 2013 Aug; 62(8):2773-83. PMID: 23545705; PMCID: PMC3717861.
      Citations: 24     Fields:    Translation:AnimalsCells
    39. Yu DH, Ware C, Waterland RA, Zhang J, Chen MH, Gadkari M, Kunde-Ramamoorthy G, Nosavanh LM, Shen L. Developmentally programmed 3' CpG island methylation confers tissue- and cell-type-specific transcriptional activation. Mol Cell Biol. 2013 May; 33(9):1845-58. PMID: 23459939; PMCID: PMC3624169.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    40. Brand S, Dicke T, Harb H, Schneider-Stock R, Waterland RA, Bauer UM, von Mutius E, Garn H, Pfefferle PI, Renz H, Teich R, Yildirim A?, Tost J. Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. J Allergy Clin Immunol. 2011 Sep; 128(3):618-25.e1-7. PMID: 21680015.
      Citations: 67     Fields:    Translation:AnimalsCells
    41. Waterland RA, Kellermayer R, Laritsky E, Rayco-Solon P, Harris RA, Travisano M, Zhang W, Torskaya MS, Zhang J, Shen L, Manary MJ, Prentice AM. Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet. 2010 Dec 23; 6(12):e1001252. PMID: 21203497; PMCID: PMC3009670.
      Citations: 189     Fields:    Translation:HumansAnimalsCells
    42. Feil R, Constancia M, Fraga M, Junien C, Carel JC, Boileau P, Le Bouc Y, Deal CL, Lillycrop K, Scharfmann R, Sheppard A, Skinner M, Szyf M, Waterland RA, Waxman DJ, Whitelaw E, Ong K, Albertsson-Wikland K, Hochberg Z. Child health, developmental plasticity, and epigenetic programming. Endocr Rev. 2011 Apr; 32(2):159-224. PMID: 20971919; PMCID: PMC3365792.
      Citations: 202     Fields:    Translation:Humans
    43. Harris RA, Wang T, Coarfa C, Nagarajan RP, Hong C, Downey SL, Johnson BE, Fouse SD, Delaney A, Zhao Y, Olshen A, Ballinger T, Zhou X, Forsberg KJ, Gu J, Echipare L, O'Geen H, Lister R, Pelizzola M, Xi Y, Epstein CB, Bernstein BE, Hawkins RD, Ren B, Chung WY, Gu H, Bock C, Gnirke A, Zhang MQ, Haussler D, Ecker JR, Li W, Farnham PJ, Waterland RA, Meissner A, Marra MA, Hirst M, Milosavljevic A, Costello JF. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol. 2010 Oct; 28(10):1097-105. PMID: 20852635; PMCID: PMC2955169.
      Citations: 326     Fields:    Translation:HumansCells
    44. Kellermayer R, Balasa A, Zhang W, Lee S, Mirza S, Chakravarty A, Szigeti R, Laritsky E, Tatevian N, Smith CW, Shen L, Waterland RA. Epigenetic maturation in colonic mucosa continues beyond infancy in mice. Hum Mol Genet. 2010 Jun 01; 19(11):2168-76. PMID: 20197410; PMCID: PMC2865374.
      Citations: 30     Fields:    Translation:AnimalsCells
    45. Waterland RA. Early environmental effects on epigenetic regulation in humans. Epigenetics. 2009 Nov 16; 4(8):523-5. PMID: 19923895.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    46. Waterland RA, Kellermayer R, Rached MT, Tatevian N, Gomes MV, Zhang J, Zhang L, Chakravarty A, Zhu W, Laritsky E, Zhang W, Wang X, Shen L. Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development. Hum Mol Genet. 2009 Aug 15; 18(16):3026-38. PMID: 19457928; PMCID: PMC2714727.
      Citations: 31     Fields:    Translation:AnimalsCells
    47. Waterland RA. Is epigenetics an important link between early life events and adult disease? Horm Res. 2009 Jan; 71 Suppl 1:13-6. PMID: 19153498.
      Citations: 53     Fields:    Translation:HumansAnimals
    48. Waterland RA. Epigenetic epidemiology of obesity: application of epigenomic technology. Nutr Rev. 2008 Aug; 66 Suppl 1:S21-3. PMID: 18673482.
      Citations: 10     Fields:    Translation:HumansAnimals
    49. Waterland RA, Travisano M, Tahiliani KG, Rached MT, Mirza S. Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes (Lond). 2008 Sep; 32(9):1373-9. PMID: 18626486; PMCID: PMC2574783.
      Citations: 129     Fields:    Translation:AnimalsCells
    50. Dion V, Lin Y, Hubert L, Waterland RA, Wilson JH. Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. Hum Mol Genet. 2008 May 01; 17(9):1306-17. PMID: 18252747; PMCID: PMC3686304.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    51. Gomes MV, Waterland RA. Individual epigenetic variation: when, why, and so what? Nestle Nutr Workshop Ser Pediatr Program. 2008; 62:141-50; discussion 151-5. PMID: 18626198.
      Citations: 3     Fields:    Translation:HumansCells
    52. Benbrahim-Tallaa L, Waterland RA, Dill AL, Webber MM, Waalkes MP. Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase. Environ Health Perspect. 2007 Oct; 115(10):1454-9. PMID: 17938735; PMCID: PMC2022656.
      Citations: 71     Fields:    Translation:HumansCells
    53. Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, Shu J, Chen X, Waterland RA, Issa JP. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet. 2007 Oct; 3(10):2023-36. PMID: 17967063; PMCID: PMC2041996.
      Citations: 163     Fields:    Translation:HumansCells
    54. Shen L, Waterland RA. Methods of DNA methylation analysis. Curr Opin Clin Nutr Metab Care. 2007 Sep; 10(5):576-81. PMID: 17693740.
      Citations: 40     Fields:    Translation:HumansCells
    55. Waterland RA, Travisano M, Tahiliani KG. Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female. FASEB J. 2007 Oct; 21(12):3380-5. PMID: 17551099.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    56. Waterland RA, Michels KB. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr. 2007; 27:363-88. PMID: 17465856.
      Citations: 282     Fields:    Translation:HumansCells
    57. Waterland RA. Epigenetic mechanisms and gastrointestinal development. J Pediatr. 2006 Nov; 149(5 Suppl):S137-42. PMID: 17212956.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    58. Waterland RA, Dolinoy DC, Lin JR, Smith CA, Shi X, Tahiliani KG. Maternal methyl supplements increase offspring DNA methylation at Axin Fused. Genesis. 2006 Sep; 44(9):401-6. PMID: 16868943.
      Citations: 167     Fields:    Translation:AnimalsCells
    59. Waterland RA. Assessing the effects of high methionine intake on DNA methylation. J Nutr. 2006 06; 136(6 Suppl):1706S-1710S. PMID: 16702343.
      Citations: 86     Fields:    Translation:AnimalsCells
    60. Dolinoy DC, Weidman JR, Waterland RA, Jirtle RL. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect. 2006 Apr; 114(4):567-72. PMID: 16581547; PMCID: PMC1440782.
      Citations: 311     Fields:    Translation:AnimalsCellsPHPublic Health
    61. Waterland RA, Lin JR, Smith CA, Jirtle RL. Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum Mol Genet. 2006 Mar 01; 15(5):705-16. PMID: 16421170.
      Citations: 103     Fields:    Translation:AnimalsCells
    62. Timme-Laragy AR, Meyer JN, Waterland RA, Di Giulio RT. Analysis of CpG methylation in the killifish CYP1A promoter. Comp Biochem Physiol C Toxicol Pharmacol. 2005 Aug; 141(4):406-11. PMID: 16257583.
      Citations: 9     Fields:    Translation:AnimalsCells
    63. Waterland RA. Commentary: The global relevance of "biological Freudianism". Int J Epidemiol. 2005 Feb; 34(1):15-7. PMID: 15649966.
      Citations:    Fields:    Translation:HumansAnimals
    64. Waterland RA. Does nutrition during infancy and early childhood contribute to later obesity via metabolic imprinting of epigenetic gene regulatory mechanisms? Nestle Nutr Workshop Ser Pediatr Program. 2005; 56:157-71; discussion 171-4. PMID: 16632951.
      Citations: 10     Fields:    Translation:Humans
    65. Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition. 2004 Jan; 20(1):63-8. PMID: 14698016.
      Citations: 230     Fields:    Translation:HumansAnimalsCells
    66. Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. 2003 Aug; 23(15):5293-300. PMID: 12861015; PMCID: PMC165709.
      Citations: 657     Fields:    Translation:AnimalsCells
    67. Wylie AA, Pulford DJ, McVie-Wylie AJ, Waterland RA, Evans HK, Chen YT, Nolan CM, Orton TC, Jirtle RL. Tissue-specific inactivation of murine M6P/IGF2R. Am J Pathol. 2003 Jan; 162(1):321-8. PMID: 12507915; PMCID: PMC1851115.
      Citations: 23     Fields:    Translation:Animals
    68. Waterland RA. Do maternal methyl supplements in mice affect DNA methylation of offspring? J Nutr. 2003 01; 133(1):238; author reply 239. PMID: 12514298.
      Citations: 18     Fields:    Translation:AnimalsCells
    69. Oka Y, Waterland RA, Killian JK, Nolan CM, Jang HS, Tohara K, Sakaguchi S, Yao T, Iwashita A, Yata Y, Takahara T, Sato S, Suzuki K, Masuda T, Jirtle RL. M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan. Hepatology. 2002 May; 35(5):1153-63. PMID: 11981765.
      Citations: 20     Fields:    Translation:Humans
    70. Waterland RA, Garza C. Early postnatal nutrition determines adult pancreatic glucose-responsive insulin secretion and islet gene expression in rats. J Nutr. 2002 Mar; 132(3):357-64. PMID: 11880555.
      Citations: 25     Fields:    Translation:Animals
    71. Killian JK, Oka Y, Jang HS, Fu X, Waterland RA, Sohda T, Sakaguchi S, Jirtle RL. Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations. Hum Mutat. 2001; 18(1):25-31. PMID: 11438990.
      Citations: 10     Fields:    Translation:Humans
    72. Waterland RA, Garza C. Potential mechanisms of metabolic imprinting that lead to chronic disease. Am J Clin Nutr. 1999 Feb; 69(2):179-97. PMID: 9989679.
      Citations: 118     Fields:    Translation:HumansAnimalsCells
    73. Waterland RA, Berkowitz RI, Stunkard AJ, Stallings VA. Calibrated-orifice nipples for measurement of infant nutritive sucking. J Pediatr. 1998 Mar; 132(3 Pt 1):523-6. PMID: 9544914.
      Citations: 7     Fields:    Translation:Humans
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