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AYALA TOVY

TitleAdjunct Assistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
Address50 Massachusetts Ave
Cambridge, MA 02139
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reyes JM, Tovy A, Zhang L, Bortoletto AS, Rosas C, Chen CW, Waldvogel SM, Guzman AG, Aguilar R, Gupta S, Liu L, Buckley MT, Patel KR, Marcogliese AN, Li Y, Curry CV, Rando TA, Brunet A, Parchem RJ, Rau RE, Goodell MA. Erratum: Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation. iScience. 2024 Jul 19; 27(7):110313. PMID: 39027369; PMCID: PMC11255835.
      Citations:    
    2. Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Martell AG, Guzman AG, Wohlan K, Waldvogel SM, Uryu H, Tovy A, Callen E, Murdaugh RL, Richard R, Jansen S, Vissers L, de Vries BBA, Nussenzweig A, Huang S, Coarfa C, Anastas J, Takahashi K, Vassiliou G, Goodell MA. SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells. Elife. 2024 Jun 18; 12. PMID: 38896450; PMCID: PMC11186636.
      Citations: 1     Fields:    Translation:HumansCells
    3. Reyes JM, Tovy A, Zhang L, Bortoletto AS, Rosas C, Chen CW, Waldvogel SM, Guzman AG, Aguilar R, Gupta S, Liu L, Buckley MT, Patel KR, Marcogliese AN, Li Y, Curry CV, Rando T, Brunet A, Parchem RJ, Rau RE, Goodell MA, Rando TA. Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation. iScience. 2024 Mar 15; 27(3):109122. PMID: 38414863; PMCID: PMC10897855.
      Citations: 2     
    4. Chen CW, Zhang L, Dutta R, Niroula A, Miller PG, Gibson CJ, Bick AG, Reyes JM, Lee YT, Tovy A, Gu T, Waldvogel S, Chen YH, Venters BJ, Est?ve PO, Pradhan S, Keogh MC, Natarajan P, Takahashi K, Sperling AS, Goodell MA. SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. Cell Stem Cell. 2024 Feb 01; 31(2):275-277. PMID: 38306995; PMCID: PMC10981498.
      Citations:    Fields:    
    5. Patel TD, Urya H, Guzman AG, Martell AG, Tovy A, Callen E, Murdaugh R, Richard R, Nussenzweig A, Zhang L, Hsu JI, Braekeleer ED, Chen CW, Wohlan K, Waldvogel SM, Jansen S, Vissers L, de Vries BBA, Huang S, Coarfa C, Anastas JN, Takahashi K, Vassiliou G, Goodell MA. SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells. bioRxiv. 2024 Jan 17. PMID: 37693622; PMCID: PMC10491179.
      Citations:    
    6. Chen CW, Zhang L, Dutta R, Niroula A, Miller PG, Gibson CJ, Bick AG, Reyes JM, Lee YT, Tovy A, Gu T, Waldvogel S, Chen YH, Venters BJ, Est?ve PO, Pradhan S, Keogh MC, Natarajan P, Takahashi K, Sperling AS, Goodell MA. SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. Cell Stem Cell. 2023 11 02; 30(11):1503-1519.e8. PMID: 37863054; PMCID: PMC10841682.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    7. Ramabadran R, Wang JH, Reyes JM, Guzman AG, Gupta S, Rosas C, Brunetti L, Gundry MC, Tovy A, Long H, Gu T, Cullen SM, Tyagi S, Rux D, Kim JJ, Kornblau SM, Kyba M, Stossi F, Rau RE, Takahashi K, Westbrook TF, Goodell MA. DNMT3A-coordinated splicing governs the stem state switch towards differentiation in embryonic and haematopoietic stem cells. Nat Cell Biol. 2023 04; 25(4):528-539. PMID: 37024683; PMCID: PMC10337578.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    8. Tovy A, Reyes JM, Zhang L, Huang YH, Rosas C, Daquinag AC, Guzman A, Ramabadran R, Chen CW, Gu T, Gupta S, Ortinau L, Park D, Cox AR, Rau RE, Hartig SM, Kolonin MG, Goodell MA. Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis. Elife. 2022 05 30; 11. PMID: 35635747; PMCID: PMC9150890.
      Citations: 1     Fields:    Translation:Animals
    9. Gu T, Hao D, Woo J, Huang TW, Guo L, Lin X, Guzman AG, Tovy A, Rosas C, Jeong M, Zhou Y, Deneen B, Huang Y, Li W, Goodell MA. The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development. Nat Genet. 2022 05; 54(5):625-636. PMID: 35534561; PMCID: PMC9295050.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Tovy A, Rosas C, Gaikwad AS, Medrano G, Zhang L, Reyes JM, Huang YH, Arakawa T, Kurtz K, Conneely SE, Guzman AG, Aguilar R, Gao A, Chen CW, Kim JJ, Carter MT, Lasa-Aranzasti A, Valenzuela I, Brunetti L, Hicks MJ, Marcogliese AN, Goodell MA, Rau RE, Van Maldergem L. Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome. Haematologica. 2022 04 01; 107(4):887-898. PMID: 34092059; PMCID: PMC8968878.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    11. Huang YH, Chen CW, Sundaramurthy V, Slabicki M, Hao D, Watson CJ, Tovy A, Reyes JM, Dakhova O, Crovetti BR, Galonska C, Lee M, Brunetti L, Zhou Y, Tatton-Brown K, Huang Y, Cheng X, Meissner A, Valk PJM, Sanders MA, Blundell JR, Li W, Ebert BL, Goodell MA, Van Maldergem L. Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor. Cancer Discov. 2022 01; 12(1):220-235. PMID: 34429321; PMCID: PMC8758508.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    12. Tovy A, Reyes JM, Gundry MC, Brunetti L, Lee-Six H, Petljak M, Park HJ, Guzman AG, Rosas C, Jeffries AR, Baple E, Mill J, Crosby AH, Sency V, Xin B, Machado HE, Castillo D, Weitzel JN, Li W, Stratton MR, Campbell PJ, Wang H, Sanders MA, Goodell MA. Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion. Cell Stem Cell. 2020 08 06; 27(2):326-335.e4. PMID: 32673568; PMCID: PMC7494054.
      Citations: 10     Fields:    Translation:Cells
    13. Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, Zhang J, Heffernan TP, Gera S, Kovacs JJ, Marszalek JR, Bristow C, Yan Y, Garcia-Manero G, Kantarjian H, Vassiliou G, Futreal PA, Donehower LA, Takahashi K, Goodell MA. PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell. 2018 11 01; 23(5):700-713.e6. PMID: 30388424; PMCID: PMC6224657.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    14. Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K, Ainbinder E, Furth N, Tanay A, Barton M, Oren M. Corrigendum: p53 is essential for DNA methylation homeostasis in na?ve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes Dev. 2018 10 01; 32(19-20):1358. PMID: 30275045; PMCID: PMC6169834.
      Citations:    Fields:    
    15. Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K, Ainbinder E, Furth N, Tanay A, Barton M, Oren M. p53 is essential for DNA methylation homeostasis in na?ve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes Dev. 2017 05 15; 31(10):959-972. PMID: 28607180; PMCID: PMC5495125.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    16. Hertz R, Tovy A, Kirschenbaum M, Geffen M, Nozaki T, Adir N, Ankri S. The Entamoeba histolytica Dnmt2 homolog (Ehmeth) confers resistance to nitrosative stress. Eukaryot Cell. 2014 Apr; 13(4):494-503. PMID: 24562908; PMCID: PMC4000097.
      Citations: 14     Fields:    Translation:AnimalsCells
    17. Aylon Y, Sarver A, Tovy A, Ainbinder E, Oren M. Lats2 is critical for the pluripotency and proper differentiation of stem cells. Cell Death Differ. 2014 Apr; 21(4):624-33. PMID: 24413153; PMCID: PMC3950325.
      Citations: 17     Fields:    Translation:AnimalsCells
    18. Katz S, Kushnir O, Tovy A, Siman Tov R, Ankri S. The Entamoeba histolytica methylated LINE-binding protein EhMLBP provides protection against heat shock. Cell Microbiol. 2012 Jan; 14(1):58-70. PMID: 21899705.
      Citations: 1     Fields:    Translation:AnimalsCells
    19. Tovy A, Hertz R, Siman-Tov R, Syan S, Faust D, Guillen N, Ankri S. Glucose starvation boosts Entamoeba histolytica virulence. PLoS Negl Trop Dis. 2011 Aug; 5(8):e1247. PMID: 21829737; PMCID: PMC3149018.
      Citations: 22     Fields:    Translation:AnimalsCells
    20. Tietzel M, Tovy A, Ankri S, Ficner R, Schulz EC. Structure analysis of Entamoeba histolytica enolase. Acta Crystallogr D Biol Crystallogr. 2011 Jul; 67(Pt 7):619-27. PMID: 21697600.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    21. Tovy A, Ankri S. Epigenetics in the unicellular parasite Entamoeba histolytica. Future Microbiol. 2010 Dec; 5(12):1875-84. PMID: 21198420.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    22. Tovy A, Hofmann B, Helm M, Ankri S. In vitro tRNA methylation assay with the Entamoeba histolytica DNA and tRNA methyltransferase Dnmt2 (Ehmeth) enzyme. J Vis Exp. 2010 Oct 19; (44). PMID: 21048666; PMCID: PMC3185636.
      Citations: 13     Fields:    Translation:AnimalsCells
    23. Tovy A, Siman Tov R, Gaentzsch R, Helm M, Ankri S. A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity. PLoS Pathog. 2010 Feb 19; 6(2):e1000775. PMID: 20174608; PMCID: PMC2824750.
      Citations: 29     Fields:    Translation:AnimalsCells
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