"Troponin C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TROPONIN complex subunit that binds calcium and help regulate calcium-dependent muscle contraction. There are two troponin C subtypes: troponin C1 and C2. Troponin C1 is skeletal and cardiac type whereas troponin C2 is skeletal type. Troponin C1 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin C1 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
| Descriptor ID |
D019209
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| MeSH Number(s) |
D05.500.945.900 D05.750.078.730.825.900 D12.776.157.125.900 D12.776.210.500.910.900 D12.776.220.525.825.900
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Troponin C".
Below are MeSH descriptors whose meaning is more specific than "Troponin C".
This graph shows the total number of publications written about "Troponin C" by people in this website by year, and whether "Troponin C" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Troponin C" by people in Profiles.
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A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C. J Muscle Res Cell Motil. 2021 06; 42(2):323-342.
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Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. Nat Commun. 2014 Oct 03; 5:5092.
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Molecular and functional consequences of mutations in the central helix of cardiac troponin C. Arch Biochem Biophys. 2014 Apr 15; 548:46-53.
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Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. Am J Cardiol. 2011 May 01; 107(9):1375-80.
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An improved method for exchanging troponin subunits in detergent skinned rat cardiac fiber bundles. Biochem Biophys Res Commun. 1999 Sep 16; 263(1):219-23.
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Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ. Biochemistry. 1997 Jan 28; 36(4):970-8.
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Covalent binding of peptides to the N-terminal hydrophobic region of cardiac troponin C has limited effects on function. J Biol Chem. 1996 Jan 05; 271(1):244-9.
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An NMR and spin label study of the effects of binding calcium and troponin I inhibitory peptide to cardiac troponin C. Protein Sci. 1995 Apr; 4(4):671-80.
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Assignment and calcium dependence of methionyl epsilon C and epsilon H resonances in cardiac troponin C. Biochemistry. 1994 Dec 06; 33(48):14434-42.
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The presence but not the sequence of the N-terminal peptide in cardiac TnC is important for function. FEBS Lett. 1994 Jun 27; 347(2-3):152-6.