"Troponin C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TROPONIN complex subunit that binds calcium and help regulate calcium-dependent muscle contraction. There are two troponin C subtypes: troponin C1 and C2. Troponin C1 is skeletal and cardiac type whereas troponin C2 is skeletal type. Troponin C1 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin C1 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
| Descriptor ID |
D019209
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| MeSH Number(s) |
D05.500.945.900 D05.750.078.730.825.900 D12.776.157.125.900 D12.776.210.500.910.900 D12.776.220.525.825.900
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Troponin C".
Below are MeSH descriptors whose meaning is more specific than "Troponin C".
This graph shows the total number of publications written about "Troponin C" by people in this website by year, and whether "Troponin C" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 2 | 0 | 2 |
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Below are the most recent publications written about "Troponin C" by people in Profiles.
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3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP. J Gen Physiol. 2019 01 07; 151(1):9-17.
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Desensitizing mouse cardiac troponin C to calcium converts slow muscle towards a fast muscle phenotype. J Physiol. 2018 10; 596(19):4651-4663.
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Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders. J Chem Inf Model. 2017 12 26; 57(12):3056-3069.
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Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle. J Gen Physiol. 2017 Mar 06; 149(3):323-334.
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Designing proteins to combat disease: Cardiac troponin C as an example. Arch Biochem Biophys. 2016 Jul 01; 601:4-10.
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Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. Nat Commun. 2014 Oct 03; 5:5092.
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Molecular and functional consequences of mutations in the central helix of cardiac troponin C. Arch Biochem Biophys. 2014 Apr 15; 548:46-53.
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CAF reprogramming inhibits ovarian cancer progression. Cell Cycle. 2014; 13(24):3783-4.
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Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. PLoS One. 2012; 7(6):e38259.
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Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity. J Biol Chem. 2012 Jun 08; 287(24):20027-36.