"Open Reading Frames" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
| Descriptor ID |
D016366
|
| MeSH Number(s) |
G05.360.335.760.640 G05.360.340.024.340.137.650
|
| Concept/Terms |
Open Reading Frames- Open Reading Frames
- Frame, Open Reading
- Frames, Open Reading
- Open Reading Frame
- Reading Frame, Open
- Reading Frames, Open
- ORFs
- Protein Coding Region
- Coding Region, Protein
- Coding Regions, Protein
- Protein Coding Regions
- Region, Protein Coding
- Regions, Protein Coding
Unassigned Reading Frames- Unassigned Reading Frames
- Frame, Unassigned Reading
- Frames, Unassigned Reading
- Reading Frame, Unassigned
- Reading Frames, Unassigned
- Unassigned Reading Frame
- Unidentified Reading Frame
- Frame, Unidentified Reading
- Frames, Unidentified Reading
- Reading Frame, Unidentified
- Reading Frames, Unidentified
- Unidentified Reading Frames
|
Below are MeSH descriptors whose meaning is more general than "Open Reading Frames".
Below are MeSH descriptors whose meaning is more specific than "Open Reading Frames".
This graph shows the total number of publications written about "Open Reading Frames" by people in this website by year, and whether "Open Reading Frames" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1997 | 1 | 5 | 6 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 3 | 3 |
| 2000 | 1 | 5 | 6 |
| 2001 | 0 | 7 | 7 |
| 2002 | 0 | 5 | 5 |
| 2003 | 2 | 2 | 4 |
| 2004 | 1 | 5 | 6 |
| 2005 | 0 | 3 | 3 |
| 2006 | 2 | 1 | 3 |
| 2007 | 1 | 6 | 7 |
| 2008 | 0 | 5 | 5 |
| 2009 | 0 | 1 | 1 |
| 2010 | 2 | 9 | 11 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 6 | 6 |
| 2013 | 0 | 8 | 8 |
| 2014 | 1 | 7 | 8 |
| 2015 | 1 | 5 | 6 |
| 2016 | 0 | 3 | 3 |
| 2017 | 0 | 4 | 4 |
| 2018 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 4 | 5 |
| 2021 | 1 | 2 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Open Reading Frames" by people in Profiles.
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A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice. Sci Transl Med. 2024 10 02; 16(767):eadk9524.
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Gene discovery from microbial gene libraries I: protection against reactive oxygen species-driven DNA damage. Microbiol Spectr. 2024 Nov 05; 12(11):e0036524.
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CRISPR-Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading frames. Nat Struct Mol Biol. 2023 12; 30(12):1878-1892.
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CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer. J Clin Invest. 2023 03 01; 133(5).
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Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila. Elife. 2022 11 08; 11.
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Assessing kinetics and recruitment of DNA repair factors using high content screens. Cell Rep. 2021 12 28; 37(13):110176.
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Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes. Am J Hum Genet. 2022 01 06; 109(1):81-96.
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Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals. PLoS One. 2021; 16(8):e0244468.
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The R2R3-MYB transcription factor MtMYB134 orchestrates flavonol biosynthesis in Medicago truncatula. Plant Mol Biol. 2021 May; 106(1-2):157-172.
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Ending on a high note: Downstream ORFs enhance mRNA translational output. EMBO J. 2020 09 01; 39(17):e105959.