Immunoglobulin Switch Region
"Immunoglobulin Switch Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.
| Descriptor ID |
D007134
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| MeSH Number(s) |
G05.360.340.024.340.137.430 G05.360.340.024.340.335.300.500
|
| Concept/Terms |
Immunoglobulin Switch Region- Immunoglobulin Switch Region
- Ig Switch Sequences
- Ig Switch Sequence
- Sequence, Ig Switch
- Sequences, Ig Switch
- Switch Sequence, Ig
- Switch Sequences, Ig
- Switch Region, Immunoglobulin
- Immunoglobulin Switch Regions
- Region, Immunoglobulin Switch
- Regions, Immunoglobulin Switch
- Switch Regions, Immunoglobulin
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Switch Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Switch Region".
This graph shows the total number of publications written about "Immunoglobulin Switch Region" by people in this website by year, and whether "Immunoglobulin Switch Region" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin Switch Region" by people in Profiles.
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An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex. J Allergy Clin Immunol. 2015 Apr; 135(4):998-1007.e6.
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Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. Eur J Immunol. 2007 Jan; 37(1):235-9.
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CD40 employs p38 MAP kinase in IgE isotype switching. Biochem Biophys Res Commun. 2001 Nov 23; 289(1):276-81.