Connective Tissue Growth Factor
"Connective Tissue Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
| Descriptor ID |
D055513
|
| MeSH Number(s) |
D12.644.276.200.100 D12.776.467.200.100 D12.776.860.300.200.100 D23.529.237.100
|
| Concept/Terms |
Connective Tissue Growth Factor- Connective Tissue Growth Factor
- Hypertrophic Chondrocyte-Specific Protein 24
- Hypertrophic Chondrocyte Specific Protein 24
- IGF-Binding Protein-Related Protein-2
- IGF Binding Protein Related Protein 2
- IGFBP-rP2
- Insulin-Like Growth Factor Binding Protein 8
- Insulin Like Growth Factor Binding Protein 8
- CCN2 Protein
- IGFBP-8
|
Below are MeSH descriptors whose meaning is more general than "Connective Tissue Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Connective Tissue Growth Factor".
This graph shows the total number of publications written about "Connective Tissue Growth Factor" by people in this website by year, and whether "Connective Tissue Growth Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Connective Tissue Growth Factor" by people in Profiles.
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Multiomic and electrophysiologic analyses reveal that an inherited MRC2 variant causes fibroblast dysfunction and increased atrial fibrillation susceptibility. Am J Physiol Heart Circ Physiol. 2025 11 01; 329(5):H1055-H1071.
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Improved Biomarker and Imaging Analysis for Characterizing Progressive Cardiac Fibrosis in a Mouse Model of Chronic Chagasic Cardiomyopathy. J Am Heart Assoc. 2019 11 19; 8(22):e013365.
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The expression of prostaglandin receptors EP3 and EP4 in human cervix in post-term pregnancy differs between failed and successful labor induction. Acta Obstet Gynecol Scand. 2014 Feb; 93(2):159-67.
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Increased collagen deposition and elevated expression of connective tissue growth factor in human thoracic aortic dissection. Circulation. 2006 Jul 04; 114(1 Suppl):I200-5.
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Effect of transforming growth factor-beta on activity of connective tissue growth factor gene promoter in mouse NIH/3T3 fibroblasts. Acta Pharmacol Sin. 2004 Apr; 25(4):485-9.
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WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14717-22.