"Aggrecans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.
| Descriptor ID |
D053674
|
| MeSH Number(s) |
D09.698.735.200.500 D12.776.395.650.750.687.100 D12.776.503.280.437.100 D12.776.860.300.140
|
| Concept/Terms |
Aggrecans- Aggrecans
- Cartilage-Specific Proteoglycan Core Proteins
- Cartilage Specific Proteoglycan Core Proteins
- Aggrecan
|
Below are MeSH descriptors whose meaning is more general than "Aggrecans".
Below are MeSH descriptors whose meaning is more specific than "Aggrecans".
This graph shows the total number of publications written about "Aggrecans" by people in this website by year, and whether "Aggrecans" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 2 | 0 | 2 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 2 | 2 |
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Below are the most recent publications written about "Aggrecans" by people in Profiles.
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Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. Cell Death Dis. 2019 10 03; 10(10):754.
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Unfolding the Story of Proteoglycan Accumulation in Thoracic Aortic Aneurysm and Dissection. Arterioscler Thromb Vasc Biol. 2019 10; 39(10):1899-1901.
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Clinical Characterization of Patients With Autosomal Dominant Short Stature due to Aggrecan Mutations. J Clin Endocrinol Metab. 2017 Feb 01; 102(2):460-469.
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PKCe signalling activates ERK1/2, and regulates aggrecan, ADAMTS5, and miR377 gene expression in human nucleus pulposus cells. PLoS One. 2013; 8(11):e82045.
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Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens. J Immunol. 2013 Aug 01; 191(3):1404-12.
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Enhanced hyaline cartilage matrix synthesis in collagen sponge scaffolds by using siRNA to stabilize chondrocytes phenotype cultured with bone morphogenetic protein-2 under hypoxia. Tissue Eng Part C Methods. 2013 Jul; 19(7):550-67.
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Sox-9 facilitates differentiation of adipose tissue-derived stem cells into a chondrocyte-like phenotype in vitro. J Orthop Res. 2011 Aug; 29(8):1291-7.
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Aggregation of bovine anterior cruciate ligament fibroblasts or marrow stromal cells promotes aggrecan production. Biotechnol Bioeng. 2011 Jan; 108(1):151-62.
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Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage. Genesis. 2009 Dec; 47(12):805-14.
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PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science. 2009 Oct 23; 326(5952):592-6.