"Bombesin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tetradecapeptide originally obtained from the skins of toads Bombina bombina and B. variegata. It is also an endogenous neurotransmitter in many animals including mammals. Bombesin affects vascular and other smooth muscle, gastric secretion, and renal circulation and function.
| Descriptor ID |
D001839
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| MeSH Number(s) |
D06.472.699.100 D12.644.400.085 D12.644.548.100 D12.776.631.650.085 D20.888.033.137 D23.946.833.033.137
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Bombesin".
Below are MeSH descriptors whose meaning is more specific than "Bombesin".
This graph shows the total number of publications written about "Bombesin" by people in this website by year, and whether "Bombesin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 1 | 2 | 3 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bombesin" by people in Profiles.
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Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation. J Biol Chem. 2009 May 15; 284(20):13434-13445.
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Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1804-12.
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Expression of matrix metalloproteinase-9 and bombesin/gastrin-releasing peptide in human prostate cancers and their lymph node metastases. Acta Oncol. 2002; 41(3):289-96.
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Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling. J Clin Invest. 2000 Dec; 106(11):1399-407.
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Cholecystokinin induction of mob-1 chemokine expression in pancreatic acinar cells requires NF-kappaB activation. Am J Physiol. 1999 07; 277(1):C74-82.
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Stress-activated protein kinase activation is the earliest direct correlate to the induction of secretagogue-induced pancreatitis in rats. Biochem Biophys Res Commun. 1996 Oct 03; 227(1):1-7.
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Distinct cytoplasmic domains of the growth hormone receptor are required for glucocorticoid- and phorbol ester-induced decreases in growth hormone (GH) binding. These domains are different from that reported for GH-induced receptor internalization. J Biol Chem. 1996 Jul 26; 271(30):18088-94.
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Jun kinases are rapidly activated by cholecystokinin in rat pancreas both in vitro and in vivo. J Biol Chem. 1996 Mar 08; 271(10):5686-90.
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Ca2+ signaling through secretagogue and growth factor receptors on pancreatic AR42J cells. Regul Pept. 1995 Jan 26; 55(2):197-206.
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Synergistic effects of bombesin and cholecystokinin on cholesterol esterase biosynthesis and secretion by AR42J cells. Arch Biochem Biophys. 1994 Apr; 310(1):54-9.