"Epiregulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the epidermal growth factor (EGF) family of peptide growth factors that is synthesized as a transmembrane protein which can be cleaved to release a soluble active form. Epiregulin has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR.
| Descriptor ID |
D066260
|
| MeSH Number(s) |
D12.644.276.382.562 D12.776.467.382.562 D23.529.382.562
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Epiregulin".
Below are MeSH descriptors whose meaning is more specific than "Epiregulin".
This graph shows the total number of publications written about "Epiregulin" by people in this website by year, and whether "Epiregulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Epiregulin" by people in Profiles.
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Association of CpG island methylator phenotype and EREG/AREG methylation and expression in colorectal cancer. Br J Cancer. 2016 06 14; 114(12):1352-61.
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HER family receptor and ligand status in thymic carcinoma. Lung Cancer. 2012 Sep; 77(3):515-21.
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Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice. J Natl Cancer Inst. 2009 Jan 21; 101(2):107-13.
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Expression of epiregulin, a novel epidermal growth factor ligand associated with prognosis in human oral squamous cell carcinomas. Oncol Rep. 2008 Jun; 19(6):1557-64.
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Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells. Cancer Prev Res (Phila). 2008 Aug; 1(3):201-7.
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Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor. Endocrinology. 2007 Dec; 148(12):6164-75.
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Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptor. Mol Endocrinol. 2006 Jun; 20(6):1352-65.