"Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
| Descriptor ID |
D004815
|
| MeSH Number(s) |
D06.472.317.350 D12.644.276.382.500 D12.776.467.382.500 D23.529.382.500
|
| Concept/Terms |
Epidermal Growth Factor- Epidermal Growth Factor
- Growth Factor, Epidermal
- Urogastrone
- Epidermal Growth Factor-Urogastrone
- Growth Factor-Urogastrone, Epidermal
- Human Urinary Gastric Inhibitor
- beta-Urogastrone
- beta Urogastrone
- EGF
|
Below are MeSH descriptors whose meaning is more general than "Epidermal Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Epidermal Growth Factor".
This graph shows the total number of publications written about "Epidermal Growth Factor" by people in this website by year, and whether "Epidermal Growth Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 2 | 3 |
| 1995 | 2 | 6 | 8 |
| 1996 | 9 | 4 | 13 |
| 1997 | 4 | 10 | 14 |
| 1998 | 2 | 7 | 9 |
| 1999 | 4 | 6 | 10 |
| 2000 | 11 | 8 | 19 |
| 2001 | 3 | 3 | 6 |
| 2002 | 1 | 8 | 9 |
| 2003 | 9 | 4 | 13 |
| 2004 | 4 | 9 | 13 |
| 2005 | 5 | 9 | 14 |
| 2006 | 4 | 6 | 10 |
| 2007 | 5 | 15 | 20 |
| 2008 | 4 | 10 | 14 |
| 2009 | 4 | 7 | 11 |
| 2010 | 5 | 4 | 9 |
| 2011 | 3 | 9 | 12 |
| 2012 | 6 | 6 | 12 |
| 2013 | 2 | 7 | 9 |
| 2014 | 0 | 2 | 2 |
| 2015 | 3 | 3 | 6 |
| 2016 | 1 | 1 | 2 |
| 2017 | 2 | 2 | 4 |
| 2018 | 2 | 1 | 3 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
| 2022 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Epidermal Growth Factor" by people in Profiles.
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Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness. Sci Adv. 2023 06 30; 9(26):eadf2860.
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Notch Missense Mutations in Drosophila Reveal Functions of Specific EGF-like Repeats in Notch Folding, Trafficking, and Signaling. Biomolecules. 2022 11 25; 12(12).
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Elevated expression of receptors for EGF, PDGF, transferrin and folate within murine and human lupus nephritis kidneys. Clin Immunol. 2023 01; 246:109188.
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A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses. Commun Biol. 2022 10 07; 5(1):1066.
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Management of hormone receptor-positive, human epidermal growth factor 2-negative metastatic breast cancer. Breast Cancer Res Treat. 2021 Nov; 190(2):189-201.
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EGF-mediated suppression of cell extrusion during mucosal damage attenuates opportunistic fungal invasion. Cell Rep. 2021 03 23; 34(12):108896.
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Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking. Cells. 2020 05 14; 9(5).
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A Cross-Linking-Aided Immunoprecipitation/Mass Spectrometry Workflow Reveals Extensive Intracellular Trafficking in Time-Resolved, Signal-Dependent Epidermal Growth Factor Receptor Proteome. J Proteome Res. 2019 10 04; 18(10):3715-3730.
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Transient Cell-to-Cell Signaling Before Mitosis in Cultures of Human Bone Marrow-Derived Mesenchymal Stem/Stromal Cells. Stem Cells Dev. 2019 01 15; 28(2):120-128.
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Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. Glycobiology. 2018 11 01; 28(11):849-859.