"Gene Targeting" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.
| Descriptor ID |
D018390
|
| MeSH Number(s) |
E05.393.335
|
| Concept/Terms |
Gene Targeting- Gene Targeting
- Gene Targetings
- Targeting, Gene
- Targetings, Gene
|
Below are MeSH descriptors whose meaning is more general than "Gene Targeting".
Below are MeSH descriptors whose meaning is more specific than "Gene Targeting".
This graph shows the total number of publications written about "Gene Targeting" by people in this website by year, and whether "Gene Targeting" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 2 | 3 |
| 1997 | 1 | 5 | 6 |
| 1998 | 3 | 1 | 4 |
| 1999 | 1 | 7 | 8 |
| 2000 | 0 | 3 | 3 |
| 2001 | 1 | 9 | 10 |
| 2002 | 0 | 5 | 5 |
| 2003 | 2 | 5 | 7 |
| 2004 | 3 | 4 | 7 |
| 2005 | 3 | 11 | 14 |
| 2006 | 1 | 2 | 3 |
| 2007 | 2 | 3 | 5 |
| 2008 | 1 | 5 | 6 |
| 2010 | 3 | 1 | 4 |
| 2011 | 0 | 4 | 4 |
| 2012 | 1 | 3 | 4 |
| 2014 | 1 | 0 | 1 |
| 2015 | 4 | 2 | 6 |
| 2016 | 4 | 1 | 5 |
| 2017 | 1 | 3 | 4 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2025 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Gene Targeting" by people in Profiles.
-
In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene. Sci Transl Med. 2025 Feb 12; 17(785):eadk3920.
-
Noncoding RNAs: biology and applications-a Keystone Symposia report. Ann N Y Acad Sci. 2021 12; 1506(1):118-141.
-
High-Throughput Phenotypic Assay for Compounds That Influence Mitochondrial Health Using iPSC-Derived Human Neurons. SLAS Discov. 2021 07; 26(6):811-822.
-
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron. 2020 04 08; 106(1):37-65.e5.
-
Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives. Genome Res. 2019 Jun; 29(6):999-1008.
-
The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. JCI Insight. 2018 11 15; 3(22).
-
An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. Elife. 2018 08 09; 7.
-
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017 09 19; 47(3):566-581.e9.
-
Unexpected consequences: exon skipping caused by CRISPR-generated mutations. Genome Biol. 2017 06 14; 18(1):109.
-
A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells. Elife. 2017 05 31; 6.