"Gene Targeting" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.
| Descriptor ID |
D018390
|
| MeSH Number(s) |
E05.393.335
|
| Concept/Terms |
Gene Targeting- Gene Targeting
- Gene Targetings
- Targeting, Gene
- Targetings, Gene
|
Below are MeSH descriptors whose meaning is more general than "Gene Targeting".
Below are MeSH descriptors whose meaning is more specific than "Gene Targeting".
This graph shows the total number of publications written about "Gene Targeting" by people in this website by year, and whether "Gene Targeting" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 7 | 9 |
| 1996 | 2 | 3 | 5 |
| 1997 | 3 | 9 | 12 |
| 1998 | 7 | 5 | 12 |
| 1999 | 2 | 12 | 14 |
| 2000 | 3 | 5 | 8 |
| 2001 | 3 | 18 | 21 |
| 2002 | 1 | 14 | 15 |
| 2003 | 5 | 10 | 15 |
| 2004 | 3 | 6 | 9 |
| 2005 | 4 | 13 | 17 |
| 2006 | 3 | 4 | 7 |
| 2007 | 6 | 7 | 13 |
| 2008 | 1 | 6 | 7 |
| 2009 | 1 | 2 | 3 |
| 2010 | 5 | 2 | 7 |
| 2011 | 1 | 6 | 7 |
| 2012 | 2 | 6 | 8 |
| 2013 | 0 | 3 | 3 |
| 2014 | 2 | 2 | 4 |
| 2015 | 5 | 4 | 9 |
| 2016 | 4 | 1 | 5 |
| 2017 | 2 | 2 | 4 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 2 | 1 | 3 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gene Targeting" by people in Profiles.
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Mouse Gene-Targeting Strategies for Maximum Ease and Versatility. Cold Spring Harb Protoc. 2024 01 02; 2024(1):107957.
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GetPrimers: A generalized PCR-based genetic targeting primer designer enabling easy and standardized targeted gene modification across multiple systems. Yeast. 2024 Jan; 41(1-2):19-34.
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Noncoding RNAs: biology and applications-a Keystone Symposia report. Ann N Y Acad Sci. 2021 12; 1506(1):118-141.
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Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer. Life Sci Alliance. 2021 09; 4(9).
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CRISPR/Cas9 to Silence Long Non-Coding RNAs. Methods Mol Biol. 2021; 2348:175-187.
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Role of HP1? during spermatogenesis and DNA replication. Chromosoma. 2020 12; 129(3-4):215-226.
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Generation of An Endogenous FGFR2-BICC1 Gene Fusion/58 Megabase Inversion Using Single-Plasmid CRISPR/Cas9 Editing in Biliary Cells. Int J Mol Sci. 2020 Apr 02; 21(7).
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Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron. 2020 04 08; 106(1):37-65.e5.
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Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives. Genome Res. 2019 Jun; 29(6):999-1008.
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Genetic and Pharmacological Targeting of Heat Shock Protein 70 in the Mouse Amygdala-Kindling Model. ACS Chem Neurosci. 2019 03 20; 10(3):1434-1444.