Tacrolimus Binding Protein 1A
"Tacrolimus Binding Protein 1A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 12-KDa tacrolimus binding protein that is found associated with and may modulate the function of calcium release channels. It is a peptidyl-prolyl cis/trans isomerase which is inhibited by both tacrolimus (commonly called FK506) and SIROLIMUS.
| Descriptor ID |
D022061
|
| MeSH Number(s) |
D08.811.399.325.500.400.700.500 D12.776.543.750.705.400.700.500 D12.776.827.275.700.500
|
| Concept/Terms |
Tacrolimus Binding Protein 1A- Tacrolimus Binding Protein 1A
- Macrophilin-12
- Macrophilin 12
- FKBP-12
- FKBP 12
- FKBP12
- FK506-Binding Protein 1
- FK506 Binding Protein 1
- FK506-Binding Protein 1A
- FK506 Binding Protein 1A
|
Below are MeSH descriptors whose meaning is more general than "Tacrolimus Binding Protein 1A".
Below are MeSH descriptors whose meaning is more specific than "Tacrolimus Binding Protein 1A".
This graph shows the total number of publications written about "Tacrolimus Binding Protein 1A" by people in this website by year, and whether "Tacrolimus Binding Protein 1A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2006 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tacrolimus Binding Protein 1A" by people in Profiles.
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Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency. J Gen Physiol. 2025 Jan 06; 157(1).
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Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure. J Clin Invest. 2018 07 02; 128(7):3053-3070.
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Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers. Mol Ther. 2015 Sep; 23(9):1497-506.
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Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. J Biol Chem. 2014 Sep 12; 289(37):25556-70.
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Forced dimerization increases the activity of ?EGFR/EGFRvIII and enhances its oncogenicity. Mol Cancer Res. 2011 Sep; 9(9):1199-208.
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A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy. J Clin Invest. 2011 Apr; 121(4):1524-34.
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Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol. 2010 Nov; 2(11):a003996.
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Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506). Blood. 2009 Nov 26; 114(23):4784-91.
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Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior. Neuron. 2008 Dec 10; 60(5):832-45.
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FKBP12 deficiency reduces strength deficits after eccentric contraction-induced muscle injury. J Appl Physiol (1985). 2008 Aug; 105(2):527-37.