Islet Amyloid Polypeptide
"Islet Amyloid Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.
| Descriptor ID |
D058228
|
| MeSH Number(s) |
D06.472.699.587.334 D12.644.548.586.234 D12.776.049.407.500
|
| Concept/Terms |
Islet Amyloid Polypeptide- Islet Amyloid Polypeptide
- Amyloid Polypeptide, Islet
- Polypeptide, Islet Amyloid
- Pancreatic Amylin
- Amylin, Pancreatic
- IAPP Protein
- Insulinoma Amyloid Polypeptide
- Amyloid Polypeptide, Insulinoma
- Polypeptide, Insulinoma Amyloid
- Amlintide
- Amylin
|
Below are MeSH descriptors whose meaning is more general than "Islet Amyloid Polypeptide".
Below are MeSH descriptors whose meaning is more specific than "Islet Amyloid Polypeptide".
This graph shows the total number of publications written about "Islet Amyloid Polypeptide" by people in this website by year, and whether "Islet Amyloid Polypeptide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2014 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Islet Amyloid Polypeptide" by people in Profiles.
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Human Islet Amyloid Polypeptide (hIAPP) Protofibril-Specific Antibodies for Detection and Treatment of Type 2 Diabetes. Adv Sci (Weinh). 2022 12; 9(34):e2202342.
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Acute zoster plasma contains elevated amyloid, correlating with A?42 and amylin levels, and is amyloidogenic. J Neurovirol. 2020 06; 26(3):422-428.
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Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries. Kidney Int. 2020 01; 97(1):143-155.
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Conformation-specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen. J Cell Mol Med. 2019 03; 23(3):2103-2114.
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Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73. Cell Cycle. 2016; 15(2):164-71.
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Free energy simulations of amylin I26P mutation in a lipid bilayer. Eur Biophys J. 2015 Feb; 44(1-2):37-47.
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IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature. 2015 Jan 29; 517(7536):626-30.
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Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. J Am Heart Assoc. 2014 Aug 21; 3(4).
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Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circ Res. 2012 Feb 17; 110(4):598-608.
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Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia. J Clin Endocrinol Metab. 2009 May; 94(5):1608-11.