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NA LI

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
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    Collapse Research 
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    R01HL182024     (LI, NA)Aug 17, 2026 - May 31, 2030
    NIH
    LIVER DYSFUNCTION MEDIATED ATRIAL ARRHYTHMOGENESIS
    Role: Principal Investigator
    R01HL185108     (LI, NA)Aug 17, 2026 - Apr 30, 2030
    NIH
    Modulating Inflammatory Signaling in CHIP- and Aging-Associated Arrhythmogenesis
    Role: Principal Investigator
    R01HL164838     (LI, NA)Dec 20, 2023 - Nov 30, 2027
    NIH
    FKBP5 AND CARDIAC ARRHYTHMOGENESIS
    Role: Principal Investigator
    R01HL163277     (LI, NA)Mar 25, 2022 - Feb 28, 2026
    NIH
    Cardiac fibroblast inflammasome and atrial myopathy
    Role: Principal Investigator
    R01HL147108     (LI, NA ;WEHRENS, XANDER H.T.)Apr 15, 2019 - Feb 29, 2024
    NIH
    Mechanisms underlying atrial fibrillation associated with chronic kidney disease
    Role: Co-Principal Investigator
    R01HL136389     (LI, NA)Sep 1, 2017 - Nov 30, 2026
    NIH
    The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis
    Role: Principal Investigator
    R56HL131649     (LI, NA)Sep 16, 2016 - Aug 31, 2018
    NIH
    Inflammasome mediated pathogenesis of atrial fibrillation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Song J, Navarro-Garcia JA, Wu J, Saljic A, Abu-Taha I, Li L, Lahiri SK, Keefe JA, Aguilar-Sanchez Y, Moore OM, Yuan Y, Wang X, Kamler M, Mitch WE, Ruiz-Hurtado G, Hu Z, Thomas SS, Dobrev D, Wehrens XH, Li N. Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation. J Clin Invest. 2023 10 02; 133(19). PMID: 37581942; PMCID: PMC10541185.
      Citations: 31     Fields:    Translation:HumansAnimals
    2. Wang X, Song J, Yuan Y, Li L, Abu-Taha I, Heijman J, Sun L, Dobrev S, Kamler M, Xie L, Wehrens XHT, Horrigan FT, Dobrev D, Li N. Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. Circ Res. 2023 06 23; 133(1):e1-e16. PMID: 37154033; PMCID: PMC10330339.
      Citations: 14     Fields:    Translation:AnimalsCells
    3. Gawalko M, Saljic A, Li N, Abu-Taha I, Jespersen T, Linz D, Nattel S, Heijman J, Fender A, Dobrev D. Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance. Cardiovasc Res. 2023 05 02; 119(3):614-630. PMID: 35689487; PMCID: PMC10409902.
      Citations: 36     Fields:    Translation:Humans
    4. Manoj P, Kim JA, Kim S, Li T, Sewani M, Chelu MG, Li N. Sinus node dysfunction: current understanding and future directions. Am J Physiol Heart Circ Physiol. 2023 03 01; 324(3):H259-H278. PMID: 36563014; PMCID: PMC9886352.
      Citations: 23     Fields:    Translation:Humans
    5. Miyake CY, Lay EJ, Soler-Alfonso C, Glinton KE, Houck KM, Tosur M, Moran NE, Stephens SB, Scaglia F, Howard TS, Kim JJ, Pham TD, Valdes SO, Li N, Murali CN, Zhang L, Kava M, Yim D, Beach C, Webster G, Liberman L, Janson CM, Kannankeril PJ, Baxter S, Singer-Berk M, Wood J, Mackenzie SJ, Sacher M, Ghaloul-Gonzalez L, Pedroza C, Morris SA, Ehsan SA, Azamian MS, Lalani SR. Natural history of TANGO2 deficiency disorder: Baseline assessment of 73 patients. Genet Med. 2023 04; 25(4):100352. PMID: 36473599; PMCID: PMC10306319.
      Citations: 18     Fields:    Translation:Humans
    6. Zheng M, Li RG, Song J, Zhao X, Tang L, Erhardt S, Chen W, Nguyen BH, Li X, Li M, Wang J, Evans SM, Christoffels VM, Li N, Wang J. Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis. Circulation. 2022 11 29; 146(22):1694-1711. PMID: 36317529; PMCID: PMC9897204.
      Citations: 18     Fields:    Translation:HumansAnimals
    7. Ripplinger CM, Glukhov AV, Kay MW, Boukens BJ, Chiamvimonvat N, Delisle BP, Fabritz L, Hund TJ, Knollmann BC, Li N, Murray KT, Poelzing S, Quinn TA, Remme CA, Rentschler SL, Rose RA, Posnack NG. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals. Am J Physiol Heart Circ Physiol. 2022 12 01; 323(6):H1137-H1166. PMID: 36269644; PMCID: PMC9678409.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    8. Ni L, Lahiri SK, Nie J, Pan X, Abu-Taha I, Reynolds JO, Campbell HM, Wang H, Kamler M, Li N, Wei X, Wang DW, Dobrev D, Wehrens XHT, Schmitz W, M?ller FU. Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice. Cardiovasc Res. 2022 10 21; 118(13):2805-2818. PMID: 34648001; PMCID: PMC9586567.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    9. Dobrev D, Heijman J, Li N, Nattel S, Hiram R. Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology. Nat Rev Cardiol. 2023 03; 20(3):145-167. PMID: 36109633; PMCID: PMC9477170.
      Citations: 139     Fields:    Translation:AnimalsCells
    10. Miyake CY, Lay EJ, Beach CM, Ceresnak SR, Delauz CM, Howard TS, Janson CM, Jardine K, Kannankeril PJ, Kava M, Kim JJ, Liberman L, Macicek SL, Pham TD, Robertson T, Valdes SO, Webster G, Stephens SB, Milewicz DM, Azamian M, Ehsan SA, Houck KM, Soler-Alfonso C, Glinton KE, Tosur M, Li N, Xu W, Lalani SR, Zhang L. Cardiac crises: Cardiac arrhythmias and cardiomyopathy during TANGO2 deficiency related metabolic crises. Heart Rhythm. 2022 10; 19(10):1673-1681. PMID: 35568137; PMCID: PMC10642301.
      Citations: 14     Fields:    Translation:Humans
    11. Linz D, Gawalko M, Sanders P, Penders J, Li N, Nattel S, Dobrev D. Does gut microbiota affect atrial rhythm? Causalities and speculations. Eur Heart J. 2021 09 14; 42(35):3521-3525. PMID: 34338744; PMCID: PMC8442110.
      Citations: 13     Fields:    Translation:Humans
    12. Scott L, Fender AC, Saljic A, Li L, Chen X, Wang X, Linz D, Lang J, Hohl M, Twomey D, Pham TT, Diaz-Lankenau R, Chelu MG, Kamler M, Entman ML, Taffet GE, Sanders P, Dobrev D, Li N. NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias. Cardiovasc Res. 2021 06 16; 117(7):1746-1759. PMID: 33523143; PMCID: PMC8208743.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    13. Kim JA, Chelu MG, Li N. Genetics of atrial fibrillation. Curr Opin Cardiol. 2021 05 01; 36(3):281-287. PMID: 33818546; PMCID: PMC8211390.
      Citations: 12     Fields:    Translation:Humans
    14. Heijman J, Muna AP, Veleva T, Molina CE, Sutanto H, Tekook M, Wang Q, Abu-Taha IH, Gorka M, Kamler M, Ravens U, Li N, Wehrens XHT, Dobrev D, K?nzel S, El-Armouche A, Reichenspurner H, Nikolaev V, Nattel S. Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation. Circ Res. 2020 09 25; 127(8):1036-1055. PMID: 32762493; PMCID: PMC7604886.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    15. Fender AC, Kleeschulte S, Stolte S, Leineweber K, Kamler M, Li N, Dobrev D, Bode J. Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart. Basic Res Cardiol. 2020 01 07; 115(2):10. PMID: 31912235; PMCID: PMC7384378.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    16. Zhang M, Hill MC, Kadow ZA, Suh JH, Tucker NR, Hall AW, Tran TT, Swinton PS, Leach JP, Margulies KB, Ellinor PT, Li N, Martin JF. Long-range Pitx2c enhancer-promoter interactions prevent predisposition to atrial fibrillation. Proc Natl Acad Sci U S A. 2019 11 05; 116(45):22692-22698. PMID: 31636200; PMCID: PMC6842642.
      Citations: 41     Fields:    Translation:AnimalsCells
    17. Greer-Short A, Musa H, Alsina KM, Ni L, Word TA, Reynolds JO, Gratz D, Lane C, El-Refaey M, Unudurthi S, Skaf M, Li N, Fedorov VV, Wehrens XHT, Mohler PJ, Hund TJ. Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm. 2020 03; 17(3):503-511. PMID: 31622781; PMCID: PMC7056561.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    18. Chelu MG, Li N. "Sorting" SERCA2a: A novel therapeutic strategy in heart failure? Int J Cardiol. 2018 12 01; 272:306-307. PMID: 30144996; PMCID: PMC6478160.
      Citations:    Fields:    Translation:Humans
    19. Chelu MG, Li N. Biomarkers (plasma trimethylamine-N-oxide) to predict atrial fibrillation: Are we there yet? Int J Cardiol. 2018 09 15; 267:116-117. PMID: 29885821; PMCID: PMC6481160.
      Citations: 2     Fields:    Translation:Humans
    20. Wang Q, Quick AP, Cao S, Reynolds J, Chiang DY, Beavers D, Li N, Wang G, Rodney GG, Anderson ME, Wehrens XHT. Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy. Circ Arrhythm Electrophysiol. 2018 04; 11(4):e005682. PMID: 29654126; PMCID: PMC5903581.
      Citations: 18     Fields:    Translation:AnimalsCells
    21. Lai YC, Li N, Lawrence W, Wang S, Levine A, Burchhardt DM, Pautler RG, Wehrens XH, Anderson AE, Valderr?bano M. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. Epilepsia Open. 2018 Jun; 3(2):213-223. PMID: 29881800; PMCID: PMC5983128.
      Citations: 3     Fields:    
    22. Klipp RC, Li N, Wang Q, Word TA, Sibrian-Vazquez M, Strongin RM, Wehrens XHT, Abramson JJ. EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2. Heart Rhythm. 2018 04; 15(4):578-586. PMID: 29248564; PMCID: PMC5879004.
      Citations: 11     Fields:    Translation:AnimalsCells
    23. Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DM. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72. PMID: 27318036; PMCID: PMC5026590.
      Citations: 34     Fields:    Translation:AnimalsCells
    24. Li N, Wehrens XH, Schulte JS, Fehrmann E, Tekook MA, Kranick D, Fels B, Heinick A, Seidl MD, Schmitz W, M?ller FU. Cardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes. Basic Res Cardiol. 2016 Mar; 111(2):15. PMID: 26818679; PMCID: PMC4729809.
      Citations: 7     Fields:    Translation:AnimalsCells
    25. Li N. Editorial Commentary: The emerging role of epigenetics in atrial fibrillation. Trends Cardiovasc Med. 2016 May; 26(4):319-20. PMID: 26521064.
      Citations: 1     Fields:    Translation:Humans
    26. Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XH. Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505. PMID: 26162324; PMCID: PMC5109931.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    27. Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C. PHD2/3-dependent hydroxylation tunes cardiac response to ?-adrenergic stress via phospholamban. J Clin Invest. 2015 Jul 01; 125(7):2759-71. PMID: 26075818; PMCID: PMC4563684.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    28. Wang J, Bai Y, Li N, Ye W, Zhang M, Greene SB, Tao Y, Chen Y, Wehrens XH, Martin JF. Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9181-6. PMID: 24927531; PMCID: PMC4078868.
      Citations: 53     Fields:    Translation:HumansAnimals
    29. Chiang DY, Cuthbertson DW, Ruiz FR, Li N, Pereira FA. A coregulatory network of NR2F1 and microRNA-140. PLoS One. 2013; 8(12):e83358. PMID: 24349493; PMCID: PMC3857795.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    30. Voigt N, Heijman J, Wang Q, Chiang DY, Li N, Karck M, Wehrens XHT, Dobrev D, Nattel S. Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation. 2014 Jan 14; 129(2):145-156. PMID: 24249718; PMCID: PMC4342412.
      Citations: 174     Fields:    Translation:HumansCells
    31. Wehrens XH, Chiang DY, Li N. Chronic exercise: a contributing factor to atrial fibrillation? J Am Coll Cardiol. 2013 Jul 02; 62(1):78-80. PMID: 23583764; PMCID: PMC3702168.
      Citations: 1     Fields:    Translation:Animals
    32. Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM, Pereira L. Epac2 mediates cardiac ?1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22. PMID: 23363625; PMCID: PMC3690126.
      Citations: 76     Fields:    Translation:AnimalsCells
    33. Li N, Wehrens XH. Extinguishing intracellular calcium leak: a promising antiarrhythmic approach. Heart Rhythm. 2013 Jan; 10(1):108-9. PMID: 23085093; PMCID: PMC4327983.
      Citations: 1     Fields:    Translation:Animals
    34. DeGrande S, Nixon D, Koval O, Curran JW, Wright P, Wang Q, Kashef F, Chiang D, Li N, Wehrens XH, Anderson ME, Hund TJ, Mohler PJ. CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm. 2012 Dec; 9(12):2034-41. PMID: 23059182; PMCID: PMC3630478.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    35. Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 01; 125(17):2059-70. PMID: 22456474; PMCID: PMC4663993.
      Citations: 243     Fields:    Translation:HumansAnimalsCells
    36. Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Kirchhof P, Hatem S, M?ller FU. Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Int J Cardiol. 2013 Jun 20; 166(2):366-74. PMID: 22093963; PMCID: PMC7647839.
      Citations: 27     Fields:    Translation:Animals
    37. Cunha SR, Hund TJ, Hashemi S, Voigt N, Li N, Wright P, Koval O, Li J, Gudmundsson H, Gumina RJ, Karck M, Schott JJ, Probst V, Le Marec H, Anderson ME, Dobrev D, Wehrens XH, Mohler PJ. Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation. 2011 Sep 13; 124(11):1212-22. PMID: 21859974; PMCID: PMC3211046.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    38. Sarma S, Li N, van Oort RJ, Reynolds C, Skapura DG, Wehrens XH. Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13165-70. PMID: 20615971; PMCID: PMC2919918.
      Citations: 35     Fields:    Translation:AnimalsCells
    39. Li N, Jia N, Dai DZ, Hu C, Dai Y. Role of endothelin in the effects of isoprenaline on potassium currents and calsequestrin 2 expression in the heart. Clin Exp Pharmacol Physiol. 2010 May; 37(5-6):557-63. PMID: 20529095.
      Citations: 2     Fields:    Translation:AnimalsCells
    40. van Oort RJ, Respress JL, Li N, Reynolds C, De Almeida AC, Skapura DG, De Windt LJ, Wehrens XH. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension. 2010 Apr; 55(4):932-8. PMID: 20157052; PMCID: PMC2843393.
      Citations: 31     Fields:    Translation:AnimalsCells
    41. Qi MY, Feng Y, Dai DZ, Li N, Cheng YS, Dai Y. CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity. Acta Pharmacol Sin. 2010 Feb; 31(2):165-74. PMID: 20139899; PMCID: PMC4002834.
      Citations: 14     Fields:    Translation:AnimalsCells
    42. Qi MY, Liu HR, Dai DZ, Li N, Dai Y. Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats. J Pharm Pharmacol. 2008 Dec; 60(12):1687-94. PMID: 19000375.
      Citations: 12     Fields:    Translation:AnimalsCells
    43. Cui B, Cheng YS, Dai DZ, Li N, Zhang TT, Dai Y. CPU0213, a non-selective ETA/ETB receptor antagonist, improves pulmonary arteriolar remodeling of monocrotaline-induced pulmonary hypertension in rats. Clin Exp Pharmacol Physiol. 2009 Feb; 36(2):169-75. PMID: 18986320.
      Citations: 9     Fields:    Translation:Animals
    44. Xu J, Li N, Dai DZ, Yu F, Dai Y. The endothelin receptor antagonist CPU0213 is more effective than aminoguanidine to attenuate isoproterenol-induced vascular abnormality by suppressing overexpression of NADPH oxidase [correction of oxidas], ETA, ETB, and MMP9 in the vasculature. J Cardiovasc Pharmacol. 2008 Jul; 52(1):42-8. PMID: 18594475.
      Citations: 7     Fields:    Translation:AnimalsCells
    45. Li N, Jia N, Dai DZ, Dai Y. Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: a role of hyperphosphorylation of PKCepsilon. Eur J Pharmacol. 2008 Sep 04; 591(1-3):211-8. PMID: 18611397.
      Citations: 8     Fields:    Translation:AnimalsCells
    46. Li N, Dai DZ, Dai Y. CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation. Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov; 378(5):541-52. PMID: 18548232.
      Citations: 11     Fields:    Translation:AnimalsCells
    47. Li N, Yang L, Dai DZ, Wang QJ, Dai Y. Chiral separation of racemate CPU86017, an anti-arrhythmic agent, produces stereoisomers possessing favourable ion channel blockade and less alpha-adrenoceptor antagonism. Clin Exp Pharmacol Physiol. 2008 May; 35(5-6):643-50. PMID: 18177475.
      Citations: 5     Fields:    Translation:AnimalsCells
    48. Huang ZJ, Dai DZ, Li N, Na T, Ji M, Dai Y. Calcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits. Clin Exp Pharmacol Physiol. 2007 Apr; 34(4):310-7. PMID: 17324143.
      Citations: 3     Fields:    Translation:AnimalsCells
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