"RNA Polymerase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.
| Descriptor ID |
D012319
|
| MeSH Number(s) |
D08.811.913.696.445.735.270.762
|
| Concept/Terms |
RNA Polymerase II- RNA Polymerase II
- RNA Polymerase B
- RNA Pol II
- DNA-Dependent RNA Polymerase II
- DNA Dependent RNA Polymerase II
|
Below are MeSH descriptors whose meaning is more general than "RNA Polymerase II".
Below are MeSH descriptors whose meaning is more specific than "RNA Polymerase II".
This graph shows the total number of publications written about "RNA Polymerase II" by people in this website by year, and whether "RNA Polymerase II" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 1 | 1 | 2 |
| 1996 | 1 | 2 | 3 |
| 1997 | 0 | 1 | 1 |
| 1998 | 2 | 1 | 3 |
| 1999 | 3 | 0 | 3 |
| 2000 | 2 | 0 | 2 |
| 2001 | 1 | 2 | 3 |
| 2002 | 1 | 3 | 4 |
| 2003 | 2 | 2 | 4 |
| 2004 | 1 | 3 | 4 |
| 2005 | 2 | 1 | 3 |
| 2006 | 0 | 5 | 5 |
| 2007 | 1 | 3 | 4 |
| 2008 | 0 | 1 | 1 |
| 2009 | 3 | 3 | 6 |
| 2010 | 2 | 8 | 10 |
| 2011 | 1 | 3 | 4 |
| 2012 | 1 | 3 | 4 |
| 2013 | 0 | 1 | 1 |
| 2014 | 3 | 4 | 7 |
| 2015 | 2 | 4 | 6 |
| 2016 | 0 | 1 | 1 |
| 2017 | 2 | 5 | 7 |
| 2018 | 3 | 2 | 5 |
| 2019 | 2 | 1 | 3 |
| 2020 | 2 | 3 | 5 |
| 2021 | 1 | 1 | 2 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 2 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "RNA Polymerase II" by people in Profiles.
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RNA interacts with topoisomerase I to adjust DNA topology. Mol Cell. 2024 Sep 05; 84(17):3192-3208.e11.
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IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events. Mol Cell. 2023 Dec 21; 83(24):4445-4460.e7.
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HIV-1 usurps transcription start site heterogeneity of host RNA polymerase II to maximize replication fitness. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2305103120.
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Long non-coding RNAs: definitions, functions, challenges and recommendations. Nat Rev Mol Cell Biol. 2023 06; 24(6):430-447.
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A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 2022 09 16; 13(1):5453.
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A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science. 2021 Nov 26; 374(6571):1113-1121.
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Targeting transcription cycles in cancer. Nat Rev Cancer. 2022 01; 22(1):5-24.
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Genome-Wide Regulations of the Preinitiation Complex Formation and Elongating RNA Polymerase II by an E3 Ubiquitin Ligase, San1. Mol Cell Biol. 2022 01 20; 42(1):e0036821.
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The Integrator Complex in Transcription and Development. Trends Biochem Sci. 2020 11; 45(11):923-934.
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Variants in SCAF4 Cause a Neurodevelopmental Disorder and Are Associated with Impaired mRNA Processing. Am J Hum Genet. 2020 09 03; 107(3):544-554.