"X-Box Binding Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic leucine zipper transcription factor that regulates expression of MHC CLASS II GENES through its binding to a conserved X-box DNA sequence in the promoter region. It regulates the expression of genes involved in the UNFOLDED PROTEIN RESPONSE.
| Descriptor ID |
D000071717
|
| MeSH Number(s) |
D12.776.260.108.937 D12.776.930.127.937
|
| Concept/Terms |
X-Box Binding Protein 1- X-Box Binding Protein 1
- X Box Binding Protein 1
- TREB5 Protein
- Tax-Responsive Element-Binding Protein 5
- Tax Responsive Element Binding Protein 5
- XBP-1 Protein
- XBP 1 Protein
- TREB-5 Protein
- TREB 5 Protein
- XBP2 Protein
|
Below are MeSH descriptors whose meaning is more general than "X-Box Binding Protein 1".
Below are MeSH descriptors whose meaning is more specific than "X-Box Binding Protein 1".
This graph shows the total number of publications written about "X-Box Binding Protein 1" by people in this website by year, and whether "X-Box Binding Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 2 | 3 |
| 2019 | 0 | 1 | 1 |
| 2020 | 2 | 1 | 3 |
| 2024 | 1 | 0 | 1 |
| 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "X-Box Binding Protein 1" by people in Profiles.
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The canonical ER stress IRE1a/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexia. EMBO Mol Med. 2025 Dec; 17(12):3607-3635.
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XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity. Circulation. 2025 Jun 03; 151(22):1583-1605.
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The IRE1a/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle. EMBO Rep. 2024 Aug; 25(8):3627-3650.
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XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. Nat Commun. 2020 12 04; 11(1):6215.
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Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer. Mol Cancer Ther. 2021 01; 20(1):11-25.
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12-h clock regulation of genetic information flow by XBP1s. PLoS Biol. 2020 01; 18(1):e3000580.
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Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019 03 01; 363(6430):993-998.
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Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer. J Transl Med. 2018 07 09; 16(1):190.
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Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases. Science. 2018 06 15; 360(6394).
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Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018 04 02; 128(4):1283-1299.