Cyclic AMP Response Element Modulator
"Cyclic AMP Response Element Modulator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP. It plays an important role in SPERMATID development in the mammalian TESTIS.
| Descriptor ID |
D051786
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| MeSH Number(s) |
D12.776.260.108.217 D12.776.930.127.217
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cyclic AMP Response Element Modulator".
Below are MeSH descriptors whose meaning is more specific than "Cyclic AMP Response Element Modulator".
This graph shows the total number of publications written about "Cyclic AMP Response Element Modulator" by people in this website by year, and whether "Cyclic AMP Response Element Modulator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2009 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclic AMP Response Element Modulator" by people in Profiles.
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Atrial proteomic profiling reveals a switch towards profibrotic gene expression program in CREM-Ib?C-X mice with persistent atrial fibrillation. J Mol Cell Cardiol. 2024 May; 190:1-12.
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Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice. Cardiovasc Res. 2022 10 21; 118(13):2805-2818.
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The arginine methyltransferase CARM1 represses p300?ACT?CREMt activity and is required for spermiogenesis. Nucleic Acids Res. 2018 05 18; 46(9):4327-4343.
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Cardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes. Basic Res Cardiol. 2016 Mar; 111(2):15.
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p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circ Res. 2012 Feb 17; 110(4):536-50.
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Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Int J Cardiol. 2013 Jun 20; 166(2):366-74.
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Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor. FASEB J. 2010 Dec; 24(12):4917-28.
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Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis. J Biol Chem. 2010 Jan 22; 285(4):2758-70.
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Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul; 119(7):1940-51.
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Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart. Circ Res. 2007 Mar 02; 100(4):489-501.