NF-KappaB Inhibitor alpha
"NF-KappaB Inhibitor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An I-kappa B protein that inhibits the activity of dimeric NF-KAPPA B P50-REL complexes, sequesters transcription factor NF-kappaB as an inactive complex in the cytoplasm; and prevents NF-kappaB nuclear translocation and DNA binding.
| Descriptor ID |
D000072000
|
| MeSH Number(s) |
D12.644.360.365.500 D12.776.260.420.500 D12.776.476.381.500 D12.776.930.326.500
|
| Concept/Terms |
NF-KappaB Inhibitor alpha- NF-KappaB Inhibitor alpha
- Inhibitor alpha, NF-KappaB
- NF KappaB Inhibitor alpha
- alpha, NF-KappaB Inhibitor
- Major Histocompatibility Complex Enhancer-Binding Protein MAD3
- Major Histocompatibility Complex Enhancer Binding Protein MAD3
- IKappaB-alpha
- IKappaB alpha
- p40 Protein (IKappaB-alpha)
- I Kappa B-alpha Protein
- I Kappa B alpha Protein
- IKappaBalpha
|
Below are MeSH descriptors whose meaning is more general than "NF-KappaB Inhibitor alpha".
Below are MeSH descriptors whose meaning is more specific than "NF-KappaB Inhibitor alpha".
This graph shows the total number of publications written about "NF-KappaB Inhibitor alpha" by people in this website by year, and whether "NF-KappaB Inhibitor alpha" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 3 | 3 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "NF-KappaB Inhibitor alpha" by people in Profiles.
-
IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NF-?B-Induced Inflammation. J Clin Immunol. 2023 02; 43(2):421-439.
-
NF-?B Blockade by NEMO Binding Domain Peptide Ameliorates Inflammation and Neurobehavioral Sequelae After Cranial Radiation Therapy in Juvenile Mice. Int J Radiat Oncol Biol Phys. 2021 04 01; 109(5):1508-1520.
-
circ-Sirt1 controls NF-?B activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells. Nucleic Acids Res. 2019 04 23; 47(7):3580-3593.
-
Noxa/HSP27 complex delays degradation of ubiquitylated IkBa in airway epithelial cells to reduce pulmonary inflammation. Mucosal Immunol. 2018 05; 11(3):741-751.
-
XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer. Nature. 2016 Oct 06; 538(7623):114-117.
-
Targeted nuclear factor-kappaB suppression enhances gemcitabine response in human pancreatic tumor cell line murine xenografts. Surgery. 2015 Oct; 158(4):881-8; discussion 888-9.
-
a-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-?B signalling. Nat Cell Biol. 2014 Mar; 16(3):245-54.
-
XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells. Leuk Res. 2013 Aug; 37(8):974-9.
-
Silent information regulator (Sir)T1 inhibits NF-?B signaling to maintain normal skeletal remodeling. J Bone Miner Res. 2013 Apr; 28(4):960-9.
-
Activation of nuclear factor-?B in acinar cells increases the severity of pancreatitis in mice. Gastroenterology. 2013 Jan; 144(1):202-10.