"BRCA1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)
| Descriptor ID |
D019313
|
| MeSH Number(s) |
D12.776.313.125 D12.776.624.776.100 D12.776.660.100 D12.776.744.100 D12.776.930.137
|
| Concept/Terms |
BRCA1 Protein- BRCA1 Protein
- Breast Cancer Type 1 Susceptibility Protein
- Breast Cancer 1 Protein
- Ring Finger Protein 53
- BRCA1 Gene Product
- Breast Cancer 1 Gene Product
|
Below are MeSH descriptors whose meaning is more general than "BRCA1 Protein".
Below are MeSH descriptors whose meaning is more specific than "BRCA1 Protein".
This graph shows the total number of publications written about "BRCA1 Protein" by people in this website by year, and whether "BRCA1 Protein" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 3 | 3 |
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 5 | 5 |
| 1997 | 3 | 0 | 3 |
| 1998 | 2 | 2 | 4 |
| 1999 | 3 | 1 | 4 |
| 2000 | 5 | 0 | 5 |
| 2001 | 4 | 0 | 4 |
| 2002 | 7 | 1 | 8 |
| 2003 | 8 | 4 | 12 |
| 2004 | 5 | 3 | 8 |
| 2005 | 3 | 1 | 4 |
| 2006 | 3 | 1 | 4 |
| 2007 | 5 | 4 | 9 |
| 2008 | 4 | 2 | 6 |
| 2009 | 10 | 3 | 13 |
| 2010 | 3 | 4 | 7 |
| 2011 | 4 | 5 | 9 |
| 2012 | 4 | 9 | 13 |
| 2013 | 9 | 2 | 11 |
| 2014 | 9 | 4 | 13 |
| 2015 | 6 | 6 | 12 |
| 2016 | 5 | 9 | 14 |
| 2017 | 11 | 7 | 18 |
| 2018 | 10 | 6 | 16 |
| 2019 | 7 | 11 | 18 |
| 2020 | 4 | 10 | 14 |
| 2021 | 3 | 15 | 18 |
| 2022 | 5 | 8 | 13 |
| 2023 | 3 | 7 | 10 |
| 2024 | 0 | 4 | 4 |
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Below are the most recent publications written about "BRCA1 Protein" by people in Profiles.
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Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers. Cell Rep. 2024 Feb 27; 43(2):113803.
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Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): Final overall survival results from a randomized phase 3 trial. Eur J Cancer. 2024 Mar; 200:113580.
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Germline Testing in Patients With Breast Cancer: ASCO-Society of Surgical Oncology Guideline. J Clin Oncol. 2024 Feb 10; 42(5):584-604.
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Systemic Treatment of Patients With Metastatic Breast Cancer: ASCO Resource-Stratified Guideline. JCO Glob Oncol. 2024 01; 10:e2300285.
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Germline Sequencing Analysis to Inform Clinical Gene Panel Testing for Aggressive Prostate Cancer. JAMA Oncol. 2023 Nov 01; 9(11):1514-1524.
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Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins. Cell Rep Med. 2023 11 21; 4(11):101255.
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Neoadjuvant Talazoparib in Patients With Germline BRCA1/2 Mutation-Positive, Early-Stage Triple-Negative Breast Cancer: Results of a Phase II Study. Oncologist. 2023 10 03; 28(10):845-855.
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Dynamics of the DYNLL1-MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs. Nat Struct Mol Biol. 2023 10; 30(10):1456-1467.
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Identifying homologous recombination deficiency in breast cancer: genomic instability score distributions differ among breast cancer subtypes. Breast Cancer Res Treat. 2023 Nov; 202(1):191-201.
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DNA Methylation Identifies Epigenetic Subtypes of Triple-Negative Breast Cancers With Distinct Clinicopathologic and Molecular Features. Mod Pathol. 2023 11; 36(11):100306.