"Ku Autoantigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.
| Descriptor ID |
D000072200
|
| MeSH Number(s) |
D08.811.277.040.025.159.155 D08.811.399.340.155 D12.776.157.687.493 D12.776.260.525 D12.776.660.625.625 D12.776.660.720.493 D23.050.290.625
|
| Concept/Terms |
Ku Autoantigen- Ku Autoantigen
- Autoantigen, Ku
- Ku Heterodimer
- Heterodimer, Ku
- Ku Protein
- Ku Antigen
- Antigen, Ku
- G22P1 Antigen
- Antigen, G22P1
Ku80 Antigen- Ku80 Antigen
- Antigen, Ku80
- Ku Autoantigen, 80 kDa
- XRCC5 Protein
- X-ray Repair Cross-Complementing Protein 5
- X ray Repair Cross Complementing Protein 5
Ku70 Antigen- Ku70 Antigen
- Antigen, Ku70
- Ku Autoantigen, 70 kDa
- XRCC6 Protein
- X-ray Repair Cross-Complementing Protein 6
- X ray Repair Cross Complementing Protein 6
|
Below are MeSH descriptors whose meaning is more general than "Ku Autoantigen".
Below are MeSH descriptors whose meaning is more specific than "Ku Autoantigen".
This graph shows the total number of publications written about "Ku Autoantigen" by people in this website by year, and whether "Ku Autoantigen" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 3 | 3 |
| 2013 | 0 | 2 | 2 |
| 2018 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Ku Autoantigen" by people in Profiles.
-
Ku DNA End-Binding Activity Promotes Repair Fidelity and Influences End-Processing During Nonhomologous End-Joining in Saccharomyces cerevisiae. Genetics. 2018 05; 209(1):115-128.
-
Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. PLoS One. 2014; 9(1):e87203.
-
Engineered proteins detect spontaneous DNA breakage in human and bacterial cells. Elife. 2013 Oct 29; 2:e01222.
-
TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres. Cell Rep. 2013 Oct 17; 5(1):194-206.
-
A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining. Oncogene. 2014 May 22; 33(21):2748-57.
-
Repair of chromosomal double-strand breaks by precise ligation in human cells. DNA Repair (Amst). 2013 Jul; 12(7):480-7.
-
Ku70 functions in addition to nonhomologous end joining in pancreatic ?-cells: a connection to ?-catenin regulation. Diabetes. 2013 Jul; 62(7):2429-38.
-
The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. EMBO J. 2013 Jan 09; 32(1):126-39.
-
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol. 2012 Jan 22; 19(2):201-6.
-
The HTLV-1 Tax oncoprotein represses Ku80 gene expression. Virology. 2011 Jul 20; 416(1-2):1-8.