X-ray Repair Cross Complementing Protein 1
"X-ray Repair Cross Complementing Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A poly(ADP)-ribose-binding protein that functions in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing radiation. It interacts with DNA LIGASE III and POLY ADP RIBOSE POLYMERASE in BASE EXCISION REPAIR, and may also function in DNA processing and chromosome recombination in GERM CELLS.
| Descriptor ID |
D000076105
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| MeSH Number(s) |
D12.776.157.687.813 D12.776.260.963 D12.776.660.720.813
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| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "X-ray Repair Cross Complementing Protein 1".
Below are MeSH descriptors whose meaning is more specific than "X-ray Repair Cross Complementing Protein 1".
This graph shows the total number of publications written about "X-ray Repair Cross Complementing Protein 1" by people in this website by year, and whether "X-ray Repair Cross Complementing Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 3 | 3 |
| 2009 | 0 | 2 | 2 |
| 2019 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "X-ray Repair Cross Complementing Protein 1" by people in Profiles.
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PARP inhibitor response is enhanced in prostate cancer when XRCC1 expression is reduced. NAR Cancer. 2025 Jun; 7(2):zcaf015.
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Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer. Cancer Discov. 2022 11 02; 12(11):2586-2605.
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Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage. Sci Rep. 2019 02 28; 9(1):3095.
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Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy. Int J Cancer. 2013 Oct 15; 133(8):2004-9.
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Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group. BMC Cancer. 2011 May 17; 11:176.
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Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. Int J Radiat Oncol Biol Phys. 2011 Nov 01; 81(3):e67-73.
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Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case-control analysis. Thyroid. 2009 Feb; 19(2):129-35.
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Association and interactions between DNA repair gene polymorphisms and adult glioma. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18(1):204-14.
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Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. Cancer. 2007 Aug 15; 110(4):867-75.
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X-ray repair cross-complementing group 1 (XRCC1) single-nucleotide polymorphisms and the risk of salivary gland carcinomas. Cancer. 2007 Jul 15; 110(2):318-25.