Proto-Oncogene Proteins c-mdm2
"Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An E3 UBIQUITIN LIGASE that interacts with and inhibits TUMOR SUPPRESSOR PROTEIN P53. Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF.
| Descriptor ID |
D051736
|
| MeSH Number(s) |
D08.811.464.938.750.562 D12.776.624.664.700.185 D12.776.660.764
|
| Concept/Terms |
Proto-Oncogene Proteins c-mdm2- Proto-Oncogene Proteins c-mdm2
- Proto Oncogene Proteins c mdm2
- c-mdm2, Proto-Oncogene Proteins
- Mdm2 Protein
- Double Minute 2 Protein
- c-mdm2 Proto-Oncogene Protein
- Proto-Oncogene Protein, c-mdm2
- c mdm2 Proto Oncogene Protein
- Murine Double Minute 2 Protein
- Mdm-2 Protein
- Mdm 2 Protein
- MDMX Protein
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-mdm2".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-mdm2".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-mdm2" by people in this website by year, and whether "Proto-Oncogene Proteins c-mdm2" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 4 | 4 |
| 1996 | 0 | 7 | 7 |
| 1997 | 0 | 6 | 6 |
| 1998 | 0 | 10 | 10 |
| 1999 | 0 | 5 | 5 |
| 2000 | 0 | 6 | 6 |
| 2001 | 0 | 8 | 8 |
| 2002 | 0 | 6 | 6 |
| 2003 | 0 | 12 | 12 |
| 2004 | 0 | 11 | 11 |
| 2005 | 2 | 5 | 7 |
| 2006 | 12 | 6 | 18 |
| 2007 | 9 | 5 | 14 |
| 2008 | 12 | 2 | 14 |
| 2009 | 7 | 3 | 10 |
| 2010 | 17 | 8 | 25 |
| 2011 | 9 | 9 | 18 |
| 2012 | 8 | 3 | 11 |
| 2013 | 4 | 8 | 12 |
| 2014 | 9 | 5 | 14 |
| 2015 | 6 | 4 | 10 |
| 2016 | 4 | 6 | 10 |
| 2017 | 4 | 1 | 5 |
| 2018 | 3 | 5 | 8 |
| 2019 | 2 | 3 | 5 |
| 2020 | 3 | 2 | 5 |
| 2021 | 2 | 1 | 3 |
| 2022 | 2 | 2 | 4 |
| 2023 | 1 | 3 | 4 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-mdm2" by people in Profiles.
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MDM2-p53 in liposarcoma: The need for targeted therapies with novel mechanisms of action. Cancer Treat Rev. 2024 Jan; 122:102668.
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Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias. Sci Adv. 2023 12; 9(48):eadh1436.
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Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage. Cell Death Dis. 2023 06 23; 14(6):371.
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A First-in-Human Phase I Study of Milademetan, an MDM2 Inhibitor, in Patients With Advanced Liposarcoma, Solid Tumors, or Lymphomas. J Clin Oncol. 2023 03 20; 41(9):1714-1724.
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Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer. Oncogene. 2023 01; 42(5):364-373.
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Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo. Cancer Res. 2022 04 01; 82(7):1313-1320.
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Epstein Barr virus-positive B-cell lymphoma is highly vulnerable to MDM2 inhibitors in vivo. Blood Adv. 2022 02 08; 6(3):891-901.
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Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations. Sci Rep. 2022 01 24; 12(1):1248.
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Phase 1 Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53. Clin Cancer Res. 2021 10 01; 27(19):5236-5247.
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Inhibition of nonsense-mediated decay rescues p53?/? isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers. J Biol Chem. 2021 11; 297(5):101163.