"Complement C1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
| Descriptor ID |
D003172
|
| MeSH Number(s) |
D12.776.124.486.274.050
|
| Concept/Terms |
Complement C1- Complement C1
- C1, Complement
- C1 Complement
- Complement, C1
- Complement 1
- Complement Component 1
- Component 1, Complement
|
Below are MeSH descriptors whose meaning is more general than "Complement C1".
Below are MeSH descriptors whose meaning is more specific than "Complement C1".
This graph shows the total number of publications written about "Complement C1" by people in this website by year, and whether "Complement C1" was a major or minor topic of these publications.
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Below are the most recent publications written about "Complement C1" by people in Profiles.
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Cardiolipin-protein complexes and initiation of complement activation after coronary artery occlusion. Circ Res. 1994 Sep; 75(3):546-55.
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Molecular basis of complement activation in ischemic myocardium: identification of specific molecules of mitochondrial origin that bind human C1q and fix complement. Circ Res. 1989 Mar; 64(3):607-15.
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Association of levels of circulating C1q binding macromolecules with induction chemotherapy response in head and neck cancer patients. Cancer Res. 1988 Oct 15; 48(20):5868-73.
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Mechanism of complement activation after coronary artery occlusion: evidence that myocardial ischemia in dogs causes release of constituents of myocardial subcellular origin that complex with human C1q in vivo. Circ Res. 1988 Mar; 62(3):572-84.
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The effect of age on the character of immune complex disease: a comparison of the incidence and relative size of materials reactive with Clq in sera of patients with glomerulonephritis and cancer. Medicine (Baltimore). 1979 Jan; 58(1):65-79.
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The C1q binding test for soluble immune complexes: clinical correlations obtained in patients with cancer. J Natl Cancer Inst. 1977 May; 58(5):1205-15.
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Soluble immune complexes in sera of patients with nephritis. Kidney Int. 1976 Sep; 10(3):256-63.