"Properdin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
| Descriptor ID |
D011414
|
| MeSH Number(s) |
D12.776.124.486.274.965 D12.776.124.790.223.624 D12.776.377.715.182.624
|
| Concept/Terms |
Properdin- Properdin
- Complement Factor P
- Factor P, Complement
|
Below are MeSH descriptors whose meaning is more general than "Properdin".
Below are MeSH descriptors whose meaning is more specific than "Properdin".
This graph shows the total number of publications written about "Properdin" by people in this website by year, and whether "Properdin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Properdin" by people in Profiles.
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Exploring urine:serum fractional excretion ratios as potential biomarkers for lupus nephritis. Front Immunol. 2022; 13:910993.
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Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities. Nat Commun. 2020 05 04; 11(1):2197.
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Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops. Ann Rheum Dis. 2019 06; 78(6):787-795.
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Expression of complement components coincides with early patterning and organogenesis in Xenopus laevis. Int J Dev Biol. 2008; 52(8):1123-33.