"Complement Factor H" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).
| Descriptor ID |
D017242
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| MeSH Number(s) |
D12.776.124.486.274.920.325.200 D12.776.124.790.223.200 D12.776.377.715.182.200
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Complement Factor H".
Below are MeSH descriptors whose meaning is more specific than "Complement Factor H".
This graph shows the total number of publications written about "Complement Factor H" by people in this website by year, and whether "Complement Factor H" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Factor H" by people in Profiles.
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Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine. Nat Commun. 2025 Apr 07; 16(1):2898.
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CspZ FH-Binding Sites as Epitopes Promote Antibody-Mediated Lyme Borreliae Clearance. Infect Immun. 2022 07 21; 90(7):e0006222.
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The Factor H-Binding Site of CspZ as a Protective Target against Multistrain, Tick-Transmitted Lyme Disease. Infect Immun. 2020 04 20; 88(5).
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Human complement factor H is a reductase for large soluble von Willebrand factor multimers--brief report. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2524-8.
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The interaction between factor H and Von Willebrand factor. PLoS One. 2013; 8(8):e73715.
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Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome. Blood. 2013 Aug 22; 122(8):1487-93.
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Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC study. Am J Hypertens. 2008 May; 21(5):533-8.
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Proteomic profiling of urinary protein excretion in the factor H-deficient mouse. Am J Nephrol. 2006; 26(2):127-35.