Spike Glycoprotein, Coronavirus
"Spike Glycoprotein, Coronavirus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.
Descriptor ID |
D064370
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MeSH Number(s) |
D12.776.543.512.500.665 D12.776.964.970.880.910.665
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Concept/Terms |
Spike Glycoprotein, Coronavirus- Spike Glycoprotein, Coronavirus
- Coronavirus Spike Glycoprotein
- Spike Protein, Coronavirus
- Coronavirus Spike Protein
- Glycoprotein S, Coronavirus
- Spike Glycoproteins, Coronavirus
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Below are MeSH descriptors whose meaning is more general than "Spike Glycoprotein, Coronavirus".
Below are MeSH descriptors whose meaning is more specific than "Spike Glycoprotein, Coronavirus".
This graph shows the total number of publications written about "Spike Glycoprotein, Coronavirus" by people in this website by year, and whether "Spike Glycoprotein, Coronavirus" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2004 | 0 | 2 | 2 |
2005 | 0 | 3 | 3 |
2007 | 0 | 2 | 2 |
2012 | 0 | 1 | 1 |
2013 | 1 | 0 | 1 |
2017 | 1 | 0 | 1 |
2020 | 15 | 7 | 22 |
2021 | 25 | 15 | 40 |
2022 | 2 | 40 | 42 |
2023 | 2 | 12 | 14 |
2024 | 1 | 2 | 3 |
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Below are the most recent publications written about "Spike Glycoprotein, Coronavirus" by people in Profiles.
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Prozone masks elevated SARS-CoV-2 antibody level measurements. PLoS One. 2024; 19(3):e0301232.
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Recombinant Rod Domain of Vimentin Reduces SARS-CoV-2 Viral Replication by Blocking Spike Protein-ACE2 Interactions. Int J Mol Sci. 2024 Feb 20; 25(5).
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Antiviral fibrils of self-assembled peptides with tunable compositions. Nat Commun. 2024 Feb 07; 15(1):1142.
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SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters1. Emerg Microbes Infect. 2023 Dec; 12(2):2245921.
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Impaired potency of neutralizing antibodies against cell-cell fusion mediated by SARS-CoV-2. Emerg Microbes Infect. 2023 Dec; 12(1):2210237.
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Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2. Emerg Microbes Infect. 2023 Dec; 12(1):2146538.
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Functional assessments of SARS-CoV-2 single-round infectious particles with variant-specific spike proteins on infectivity, drug sensitivity, and antibody neutralization. Antiviral Res. 2023 12; 220:105744.
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SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors. Nat Commun. 2023 10 23; 14(1):6725.
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Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike. Nature. 2023 Dec; 624(7992):639-644.
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Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking. Immunity. 2023 Oct 10; 56(10):2442-2455.e8.