"Anaphylatoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum peptides derived from certain cleaved COMPLEMENT PROTEINS during COMPLEMENT ACTIVATION. They induce smooth MUSCLE CONTRACTION; mast cell HISTAMINE RELEASE; PLATELET AGGREGATION; and act as mediators of the local inflammatory process. The order of anaphylatoxin activity from the strongest to the weakest is C5a, C3a, C4a, and C5a des-arginine.
| Descriptor ID |
D000706
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| MeSH Number(s) |
D12.776.124.486.274.024
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Anaphylatoxins".
Below are MeSH descriptors whose meaning is more specific than "Anaphylatoxins".
This graph shows the total number of publications written about "Anaphylatoxins" by people in this website by year, and whether "Anaphylatoxins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Anaphylatoxins" by people in Profiles.
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The C5a anaphylatoxin receptor (C5aR1) protects against Listeria monocytogenes infection by inhibiting type 1 IFN expression. J Immunol. 2014 Nov 15; 193(10):5099-107.
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Preeclampsia and pregnancies with small-for-gestational age neonates have different profiles of complement split products. J Matern Fetal Neonatal Med. 2010 Jul; 23(7):646-57.
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Increased concentration of the complement split product C5a in acute pyelonephritis during pregnancy. J Matern Fetal Neonatal Med. 2005 Apr; 17(4):247-52.
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Normal pregnancy is characterized by systemic activation of the complement system. J Matern Fetal Neonatal Med. 2005 Apr; 17(4):239-45.
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Platelet activation leads to activation and propagation of the complement system. J Exp Med. 2005 Mar 21; 201(6):871-9.
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Anaphylatoxins in preterm and term labor. J Perinat Med. 2005; 33(4):306-13.
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Role of the complement system in ischaemic heart disease: potential for pharmacological intervention. BioDrugs. 2001; 15(9):595-607.