"Complement C3a" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
| Descriptor ID |
D015926
|
| MeSH Number(s) |
D12.776.124.486.274.024.250 D12.776.124.486.274.250.250
|
| Concept/Terms |
Complement C3a- Complement C3a
- C3a, Complement
- Complement 3a
- Complement Component 3a
- Component 3a, Complement
- C3a Complement
- Complement, C3a
|
Below are MeSH descriptors whose meaning is more general than "Complement C3a".
Below are MeSH descriptors whose meaning is more specific than "Complement C3a".
This graph shows the total number of publications written about "Complement C3a" by people in this website by year, and whether "Complement C3a" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C3a" by people in Profiles.
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Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging. J Clin Invest. 2021 01 04; 131(1).
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C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina. Front Neural Circuits. 2020; 14:583391.
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Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease. Neuron. 2018 12 19; 100(6):1337-1353.e5.
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Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells. J Biol Chem. 2018 05 11; 293(19):7195-7208.
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The Complement Anaphylatoxins C5a and C3a Suppress IFN-? Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway. J Immunol. 2017 04 15; 198(8):3237-3244.
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Loss of Peripheral Tolerance in Emphysema. Phenotypes, Exacerbations, and Disease Progression. Ann Am Thorac Soc. 2015 Nov; 12 Suppl 2:S164-8.
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Activation of C3a receptor is required in cigarette smoke-mediated emphysema. Mucosal Immunol. 2015 Jul; 8(4):874-85.
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Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia. J Reprod Immunol. 2013 Apr; 97(2):211-6.
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IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J Immunol. 2008 May 01; 180(9):5882-9.
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Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. Mol Immunol. 2008 Apr; 45(7):1907-15.