Complement Membrane Attack Complex
"Complement Membrane Attack Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
| Descriptor ID |
D015938
|
| MeSH Number(s) |
D12.776.124.486.274.930
|
| Concept/Terms |
Complement Membrane Attack Complex- Complement Membrane Attack Complex
- C5b-8-poly-C9
- C5b 8 poly C9
- Terminal Complement Complex
- Complement Complex, Terminal
- Complex, Terminal Complement
- Complement Complex C5b-9
- Complement Complex C5b 9
- Cytolytic Terminal Complement Complex
- Membrane Attack Complex
- C 5b-9
- C5b-9
|
Below are MeSH descriptors whose meaning is more general than "Complement Membrane Attack Complex".
Below are MeSH descriptors whose meaning is more specific than "Complement Membrane Attack Complex".
This graph shows the total number of publications written about "Complement Membrane Attack Complex" by people in this website by year, and whether "Complement Membrane Attack Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement Membrane Attack Complex" by people in Profiles.
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Extrahepatic Nonreticuloendothelial Siderosis Is Not Specific to Gestational Alloimmune Liver Disease. Pediatr Dev Pathol. 2019 Jul-Aug; 22(4):356-364.
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Upregulation and release of soluble fms-like tyrosine kinase receptor 1 mediated by complement activation in human syncytiotrophoblast cells. Am J Reprod Immunol. 2018 11; 80(5):e13033.
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Thrombotic microangiopathies and the linkage between von Willebrand factor and the alternative complement pathway. Semin Thromb Hemost. 2014 Jul; 40(5):544-50.
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Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in mice. J Neuroinflammation. 2009 Jan 08; 6:2.
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Dynamic expression of the membrane attack complex (MAC) of the complement system in failing human myocardium. Am J Cardiol. 2006 Jun 01; 97(11):1626-9.
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Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia. Clin Cancer Res. 2003 Oct 01; 9(12):4570-7.
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Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells. Oncogene. 2003 Sep 18; 22(40):6296-300.
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Endothelial nuclear factor-kappaB translocation and vascular cell adhesion molecule-1 induction by complement: inhibition with anti-human C5 therapy or cGMP analogues. Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2623-9.