"Complement C8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.
| Descriptor ID |
D003185
|
| MeSH Number(s) |
D12.776.124.486.274.750
|
| Concept/Terms |
Complement C8- Complement C8
- C8, Complement
- Complement Component 8
- Component 8, Complement
- C8 Complement
- Complement, C8
- Complement 8
|
Below are MeSH descriptors whose meaning is more general than "Complement C8".
Below are MeSH descriptors whose meaning is more specific than "Complement C8".
This graph shows the total number of publications written about "Complement C8" by people in this website by year, and whether "Complement C8" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C8" by people in Profiles.
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Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004310.
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Differences in cell-bound C8 sites on chicken erythrocytes measured by their reactivity with guinea pig and human C9. J Immunol. 1980 Dec; 125(6):2818-22.
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Distinction between C8-mediated and C8/C9-mediated hemolysis on the basis of independent 86Rb and hemoglobin release. J Immunol. 1980 Apr; 124(4):1905-10.