"PTEN Phosphohydrolase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.
Descriptor ID |
D051059
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MeSH Number(s) |
D08.811.277.352.650.850 D12.776.476.590 D12.776.624.776.695
|
Concept/Terms |
PTEN Phosphohydrolase- PTEN Phosphohydrolase
- Phosphohydrolase, PTEN
- PTEN Protein
- Phosphatase and Tensin Homologue on Chromosome Ten Protein
- PTEN Phosphatase
- Phosphatase, PTEN
- MMAC1 Protein
- PTEN Protein Phosphatase
- Phosphatase, PTEN Protein
- Protein Phosphatase, PTEN
- Mutated In Multiple Advanced Cancers 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "PTEN Phosphohydrolase".
Below are MeSH descriptors whose meaning is more specific than "PTEN Phosphohydrolase".
This graph shows the total number of publications written about "PTEN Phosphohydrolase" by people in this website by year, and whether "PTEN Phosphohydrolase" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 3 | 3 |
1998 | 0 | 10 | 10 |
1999 | 0 | 7 | 7 |
2000 | 0 | 2 | 2 |
2001 | 0 | 7 | 7 |
2002 | 0 | 9 | 9 |
2003 | 1 | 10 | 11 |
2004 | 0 | 7 | 7 |
2005 | 4 | 13 | 17 |
2006 | 11 | 10 | 21 |
2007 | 10 | 8 | 18 |
2008 | 15 | 6 | 21 |
2009 | 16 | 9 | 25 |
2010 | 15 | 5 | 20 |
2011 | 15 | 16 | 31 |
2012 | 15 | 17 | 32 |
2013 | 11 | 12 | 23 |
2014 | 11 | 13 | 24 |
2015 | 22 | 8 | 30 |
2016 | 9 | 11 | 20 |
2017 | 18 | 11 | 29 |
2018 | 7 | 5 | 12 |
2019 | 11 | 3 | 14 |
2020 | 5 | 5 | 10 |
2021 | 3 | 5 | 8 |
2022 | 0 | 2 | 2 |
2023 | 1 | 4 | 5 |
2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "PTEN Phosphohydrolase" by people in Profiles.
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eEF1A2 promotes PTEN-GSK3?-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer. Sci Signal. 2024 Mar 05; 17(826):eadh4475.
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Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway. IUBMB Life. 2024 Mar; 76(3):140-160.
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MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer. Nat Commun. 2023 09 13; 14(1):5665.
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The Rare and Atypical Diabetes Network (RADIANT) Study: Design and Early Results. Diabetes Care. 2023 06 01; 46(6):1265-1270.
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Phase 1b study of pan-AKT inhibitor vevorisertib alone or with paclitaxel or fulvestrant in PIK3CA/AKT/PTEN-mutated advanced solid tumors. Cancer. 2023 06 15; 129(12):1919-1929.
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Multiplatform Analysis of Intratumoral PTEN Heterogeneity in Melanoma. J Invest Dermatol. 2023 09; 143(9):1779-1787.e1.
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Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss. Cell Death Dis. 2022 09 08; 13(9):777.
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MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade. Nat Commun. 2022 01 11; 13(1):245.
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Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway. Int J Biol Sci. 2022; 18(1):229-241.
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Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice. Mol Oncol. 2022 03; 16(5):1184-1199.