eIF-2 Kinase

"eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.

Descriptor ID	D019892
MeSH Number(s)	D08.811.913.696.620.682.700.300 D12.644.360.275 D12.776.476.275
Concept/Terms	eIF-2 Kinase eIF-2 Kinase Kinase, eIF-2 eIF 2 Kinase DAI Protein Kinase Kinase, DAI Protein Protein Kinase, DAI Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase Double Stranded RNA Dependent eIF 2 alpha Protein Kinase Double Stranded RNA-Dependent Kinase (dsl) dsRNA-Activated Inhibitor Inhibitor, dsRNA-Activated dsRNA Activated Inhibitor DSRNA-Dep Protein Kinase DSRNA Dep Protein Kinase Kinase, DSRNA-Dep Protein Protein Kinase, DSRNA-Dep eIF-2alpha Kinase Kinase, eIF-2alpha eIF 2alpha Kinase eRF, eIF-2 Recycling Factor eRF, eIF 2 Recycling Factor Eukaryotic Initiation Factor 2alpha Kinase Heme Controlled Repressor Controlled Repressor, Heme Repressor, Heme Controlled Heme-Controlled Inhibitor Heme Controlled Inhibitor Inhibitor, Heme-Controlled Heme-Regulated eIF-2alpha Kinase Heme Regulated eIF 2alpha Kinase Kinase, Heme-Regulated eIF-2alpha eIF-2alpha Kinase, Heme-Regulated Hemin Controlled Repressor Controlled Repressor, Hemin Repressor, Hemin Controlled p68 Kinase Kinase, p68 Self-Phosphorylating Protein Kinase Kinase, Self-Phosphorylating Protein Protein Kinase, Self-Phosphorylating Self Phosphorylating Protein Kinase TIK Kinase Kinase, TIK P68 Protein Kinase Kinase, P68 Protein Protein Kinase, P68 RNA-Dependent Protein Kinase Kinase, RNA-Dependent Protein Protein Kinase, RNA-Dependent RNA Dependent Protein Kinase p65 Kinase Kinase, p65 Protein Kinase PKR Kinase PKR, Protein PKR, Protein Kinase Protein Kinase, RNA Activated Heme-Controlled Translational Repressor Heme Controlled Translational Repressor Repressor, Heme-Controlled Translational Translational Repressor, Heme-Controlled Hemin-Controlled Translational Repressor Hemin Controlled Translational Repressor Repressor, Hemin-Controlled Translational Translational Repressor, Hemin-Controlled

Below are MeSH descriptors whose meaning is more general than "eIF-2 Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
eIF-2 Kinase [D08.811.913.696.620.682.700.300]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
eIF-2 Kinase [D12.644.360.275]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
eIF-2 Kinase [D12.776.476.275]

Below are MeSH descriptors whose meaning is related to "eIF-2 Kinase".

Below are MeSH descriptors whose meaning is more specific than "eIF-2 Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "eIF-2 Kinase" by people in this website by year, and whether "eIF-2 Kinase" was a major or minor topic of these publications.

Bar chart showing 59 publications over 24 distinct years, with a maximum of 7 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1998	1	0	1
1999	0	1	1
2000	1	0	1
2002	2	0	2
2004	1	1	2
2005	4	0	4
2006	2	1	3
2007	1	1	2
2008	4	0	4
2009	1	0	1
2010	1	2	3
2011	4	1	5
2012	1	1	2
2013	2	2	4
2014	2	0	2
2015	3	0	3
2016	1	0	1
2017	0	1	1
2018	2	1	3
2019	3	4	7
2020	1	2	3
2021	1	1	2
2022	0	1	1

Below are the most recent publications written about "eIF-2 Kinase" by people in Profiles.

Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts. Blood Cancer Discov. 2022 11 02; 3(6):554-567.

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PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer. Mol Cancer Res. 2022 02; 20(2):193-201.

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Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer. Cell Rep. 2021 08 03; 36(5):109491.

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Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast-like Cells Is Driven by an Unfolded Protein Response. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):302-316.

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De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation. Am J Hum Genet. 2020 04 02; 106(4):570-583.

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The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020 03 18; 48(5):2621-2642.

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Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science. 2019 11 15; 366(6467):843-849.

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Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene. 2020 01; 39(4):801-813.

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Suppression of Nuclear Factor-?B by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells. Mol Cancer Ther. 2019 10; 18(10):1684-1695.

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Circle the Wagons: Circular RNAs Control Innate Immunity. Cell. 2019 05 02; 177(4):797-799.

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