Crk-Associated Substrate Protein
"Crk-Associated Substrate Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION.
| Descriptor ID |
D050719
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| MeSH Number(s) |
D12.644.360.024.282 D12.776.157.057.016 D12.776.476.024.316 D12.776.744.425
|
| Concept/Terms |
Crk-Associated Substrate Protein- Crk-Associated Substrate Protein
- Crk Associated Substrate Protein
- Substrate Protein, Crk-Associated
- p130 Cas Protein
- Cas Protein, p130
- BCAR1 Protein
- p130 Crk-Associated Substrate
- Crk-Associated Substrate, p130
- Substrate, p130 Crk-Associated
- p130 Crk Associated Substrate
- p130Cas Protein
- Breast Cancer Anti-Estrogen Resistance 1 Protein
- Breast Cancer Anti Estrogen Resistance 1 Protein
- Crk-Associated Substrate
- Crk Associated Substrate
- CKRAS Protein
|
Below are MeSH descriptors whose meaning is more general than "Crk-Associated Substrate Protein".
Below are MeSH descriptors whose meaning is more specific than "Crk-Associated Substrate Protein".
This graph shows the total number of publications written about "Crk-Associated Substrate Protein" by people in this website by year, and whether "Crk-Associated Substrate Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2005 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 3 | 3 |
| 2011 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Crk-Associated Substrate Protein" by people in Profiles.
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Endothelial p130cas confers resistance to anti-angiogenesis therapy. Cell Rep. 2022 01 25; 38(4):110301.
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PTPN12/PTP-PEST Regulates Phosphorylation-Dependent Ubiquitination and Stability of Focal Adhesion Substrates in Invasive Glioblastoma Cells. Cancer Res. 2018 07 15; 78(14):3809-3822.
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Distinct gene expression profiles in two cases of Merkel cell polyomavirus-negative Merkel cell carcinoma: shedding light on an esoteric entity. Int J Dermatol. 2015 Dec; 54(12):e549-51.
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Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death. J Natl Cancer Inst. 2011 Nov 02; 103(21):1596-612.
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Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase. J Cell Sci. 2009 Jun 15; 122(Pt 12):2043-54.
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Functional significance of VEGFR-2 on ovarian cancer cells. Int J Cancer. 2009 Mar 01; 124(5):1045-53.
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Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest. 2009 Feb; 119(2):252-66.
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Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. Cancer Res. 2008 May 01; 68(9):3323-33.
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Location, location, location: the role of cyclin D1 nuclear localization in cancer. J Cell Biochem. 2005 Dec 01; 96(5):906-13.
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Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. Clin Cancer Res. 2005 Oct 01; 11(19 Pt 1):6924-32.