Structure-Activity Relationship
"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Descriptor ID |
D013329
|
MeSH Number(s) |
G02.111.830 G07.690.773.997
|
Concept/Terms |
Structure-Activity Relationship- Structure-Activity Relationship
- Relationship, Structure-Activity
- Relationships, Structure-Activity
- Structure Activity Relationship
- Structure-Activity Relationships
|
Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".
Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".
This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 24 | 24 |
1995 | 0 | 22 | 22 |
1996 | 0 | 24 | 24 |
1997 | 0 | 13 | 13 |
1998 | 0 | 11 | 11 |
1999 | 0 | 14 | 14 |
2000 | 0 | 16 | 16 |
2001 | 0 | 10 | 10 |
2002 | 1 | 16 | 17 |
2003 | 1 | 23 | 24 |
2004 | 0 | 18 | 18 |
2005 | 0 | 22 | 22 |
2006 | 1 | 29 | 30 |
2007 | 0 | 21 | 21 |
2008 | 0 | 19 | 19 |
2009 | 0 | 28 | 28 |
2010 | 0 | 20 | 20 |
2011 | 0 | 21 | 21 |
2012 | 0 | 30 | 30 |
2013 | 0 | 22 | 22 |
2014 | 0 | 19 | 19 |
2015 | 0 | 25 | 25 |
2016 | 0 | 12 | 12 |
2017 | 0 | 19 | 19 |
2018 | 0 | 14 | 14 |
2019 | 0 | 13 | 13 |
2020 | 0 | 21 | 21 |
2021 | 0 | 22 | 22 |
2022 | 0 | 4 | 4 |
2023 | 0 | 3 | 3 |
2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.
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Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers. Cell Rep. 2024 Feb 27; 43(2):113803.
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Quinazolinone Compounds Have Potent Antiviral Activity against Zika and Dengue Virus. J Med Chem. 2023 08 10; 66(15):10746-10760.
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First-in-Class Dual Targeting Compounds for the Management of Seizures in Glucose Transporter Type 1 Deficiency Syndrome. J Med Chem. 2023 07 27; 66(14):10010-10026.
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Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition. Bioorg Med Chem Lett. 2023 06 15; 90:129328.
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Nonhydrolyzable d-phenylalanine-benzoxazole derivatives retain antitubercular activity. Bioorg Med Chem Lett. 2023 01 15; 80:129116.
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Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2122506119.
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Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. Eur J Med Chem. 2022 Jul 05; 237:114407.
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Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology. J Biol Chem. 2022 03; 298(3):101720.
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Targeting NLRP3 signaling by a novel-designed sulfonylurea compound for inhibition of microglial inflammation. Bioorg Med Chem. 2022 03 15; 58:116645.
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Synthesis and structure activity relationship of the first class of LXR inverse agonists. Bioorg Chem. 2022 02; 119:105540.