Positive Transcriptional Elongation Factor B
"Positive Transcriptional Elongation Factor B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT KINASE 9 and one of several CYCLINS including TYPE T CYCLINS and cyclin K. It functions by phosphorylating the carboxy-terminal domain of RNA POLYMERASE II.
| Descriptor ID |
D042925
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| MeSH Number(s) |
D08.811.913.696.620.682.700.626 D12.776.930.955.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Positive Transcriptional Elongation Factor B".
Below are MeSH descriptors whose meaning is more specific than "Positive Transcriptional Elongation Factor B".
This graph shows the total number of publications written about "Positive Transcriptional Elongation Factor B" by people in this website by year, and whether "Positive Transcriptional Elongation Factor B" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 3 | 3 |
| 2003 | 2 | 2 | 4 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 2 | 0 | 2 |
| 2012 | 2 | 1 | 3 |
| 2014 | 2 | 1 | 3 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Positive Transcriptional Elongation Factor B" by people in Profiles.
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Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex. Nat Cancer. 2022 10; 3(10):1211-1227.
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Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP. Mol Cell. 2022 05 05; 82(9):1708-1723.e10.
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Regulation of cyclin T1 during HIV replication and latency establishment in human memory CD4 T cells. Virol J. 2019 02 20; 16(1):22.
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TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb. Elife. 2019 01 17; 8.
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Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex. Cell Rep. 2018 08 21; 24(8):2141-2154.e6.
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Short Communication: The Broad-Spectrum Histone Deacetylase Inhibitors Vorinostat and Panobinostat Activate Latent HIV in CD4(+) T Cells In Part Through Phosphorylation of the T-Loop of the CDK9 Subunit of P-TEFb. AIDS Res Hum Retroviruses. 2016 Feb; 32(2):169-73.
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FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency. J Biol Chem. 2015 Nov 06; 290(45):27297-27310.
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Short communication: SAHA (vorinostat) induces CDK9 Thr-186 (T-loop) phosphorylation in resting CD4+ T cells: implications for reactivation of latent HIV. AIDS Res Hum Retroviruses. 2015 Jan; 31(1):137-41.
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Inhibition of P-TEFb by DRB suppresses SIRT1/CK2a pathway and enhances radiosensitivity of human cancer cells. Anticancer Res. 2014 Dec; 34(12):6981-9.
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Hormone-induced and DNA demethylation-induced relief of a tissue-specific and developmentally regulated block in transcriptional elongation. J Biol Chem. 2014 Dec 19; 289(51):35087-101.