"14-3-3 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.
| Descriptor ID |
D048948
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| MeSH Number(s) |
D12.644.360.024.050 D12.776.157.057.002 D12.776.476.024.050
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| Concept/Terms |
14-3-3 Proteins- 14-3-3 Proteins
- 14 3 3 Proteins
- 14-3-3 Protein
- 14 3 3 Protein
- Brain 14-3-3 Protein
- 14-3-3 Protein, Brain
- Brain 14 3 3 Protein
- Protein 14-3-3
14-3-3 Protein, tau Isoform- 14-3-3 Protein, tau Isoform
- 14 3 3 Protein, tau Isoform
- 14-3-3tau Protein
- 14 3 3tau Protein
- Protein, 14-3-3tau
- 14-3-3 tau Protein
- 14 3 3 tau Protein
14-3-3 Protein, zeta Isoform- 14-3-3 Protein, zeta Isoform
- 14 3 3 Protein, zeta Isoform
- 14-3-3zeta Protein
- 14 3 3zeta Protein
- 14-3-3 zeta Protein
- 14 3 3 zeta Protein
14-3-3 Protein, eta Isoform- 14-3-3 Protein, eta Isoform
- 14 3 3 Protein, eta Isoform
- 14-3-3eta Protein
- 14 3 3eta Protein
- 14-3-3 eta Protein
- 14 3 3 eta Protein
- eta Protein, 14-3-3
14-3-3 Protein, epsilon Isoform- 14-3-3 Protein, epsilon Isoform
- 14 3 3 Protein, epsilon Isoform
- 14-3-3 epsilon Protein
- 14 3 3 epsilon Protein
- 14-3-3epsilon Protein
- 14 3 3epsilon Protein
14-3-3 Protein, gamma Isoform- 14-3-3 Protein, gamma Isoform
- 14 3 3 Protein, gamma Isoform
- 14-3-3gamma Protein
- 14 3 3gamma Protein
- 14-3-3 gamma Protein
- 14 3 3 gamma Protein
14-3-3 Protein, beta Isoform- 14-3-3 Protein, beta Isoform
- 14 3 3 Protein, beta Isoform
- 14-3-3beta Protein
- 14 3 3beta Protein
- 14-3-3 beta Protein
- 14 3 3 beta Protein
|
Below are MeSH descriptors whose meaning is more general than "14-3-3 Proteins".
Below are MeSH descriptors whose meaning is more specific than "14-3-3 Proteins".
This graph shows the total number of publications written about "14-3-3 Proteins" by people in this website by year, and whether "14-3-3 Proteins" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 3 | 3 |
| 1998 | 0 | 3 | 3 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 4 | 4 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 4 | 4 |
| 2004 | 1 | 2 | 3 |
| 2005 | 0 | 4 | 4 |
| 2006 | 0 | 6 | 6 |
| 2007 | 4 | 2 | 6 |
| 2008 | 2 | 0 | 2 |
| 2009 | 4 | 1 | 5 |
| 2010 | 5 | 1 | 6 |
| 2011 | 4 | 1 | 5 |
| 2012 | 0 | 2 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 1 | 3 |
| 2015 | 4 | 2 | 6 |
| 2016 | 3 | 0 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 4 | 0 | 4 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "14-3-3 Proteins" by people in Profiles.
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YWHAE loss of function causes a rare neurodevelopmental disease with brain abnormalities in human and mouse. Genet Med. 2023 07; 25(7):100835.
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Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3? protein and represses lung cancer metastasis. Cancer Biol Ther. 2022 12 31; 23(1):265-280.
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14-3-3t drives estrogen receptor loss via ERa36 induction and GATA3 inhibition in breast cancer. Proc Natl Acad Sci U S A. 2022 10 25; 119(43):e2209211119.
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Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3. Cell Death Dis. 2021 11 26; 12(12):1105.
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A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1. J Mol Biol. 2021 09 17; 433(19):167174.
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Stratifin in ocular surface squamous neoplasia and its association with p53. Acta Ophthalmol. 2021 Dec; 99(8):e1483-e1491.
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The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer. Commun Biol. 2021 01 22; 4(1):103.
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Phosphorylation of Connexin36 near the C-terminus switches binding affinities for PDZ-domain and 14-3-3 proteins in vitro. Sci Rep. 2020 10 27; 10(1):18378.
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cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis. Cell Rep. 2019 08 13; 28(7):1799-1813.e5.
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Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Mol Cell. 2019 06 20; 74(6):1123-1137.e6.