"Enzyme Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
| Descriptor ID |
D004789
|
| MeSH Number(s) |
G02.111.263 G03.328
|
| Concept/Terms |
Enzyme Activation- Enzyme Activation
- Activation, Enzyme
- Activations, Enzyme
- Enzyme Activations
|
Below are MeSH descriptors whose meaning is more general than "Enzyme Activation".
Below are MeSH descriptors whose meaning is more specific than "Enzyme Activation".
This graph shows the total number of publications written about "Enzyme Activation" by people in this website by year, and whether "Enzyme Activation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 12 | 12 |
| 1997 | 0 | 9 | 9 |
| 1998 | 0 | 12 | 12 |
| 1999 | 0 | 17 | 17 |
| 2000 | 1 | 16 | 17 |
| 2001 | 0 | 8 | 8 |
| 2002 | 0 | 22 | 22 |
| 2003 | 0 | 14 | 14 |
| 2004 | 0 | 22 | 22 |
| 2005 | 0 | 26 | 26 |
| 2006 | 0 | 16 | 16 |
| 2007 | 0 | 14 | 14 |
| 2008 | 0 | 20 | 20 |
| 2009 | 0 | 18 | 18 |
| 2010 | 0 | 26 | 26 |
| 2011 | 1 | 23 | 24 |
| 2012 | 0 | 19 | 19 |
| 2013 | 1 | 14 | 15 |
| 2014 | 1 | 16 | 17 |
| 2015 | 0 | 18 | 18 |
| 2016 | 0 | 11 | 11 |
| 2017 | 0 | 10 | 10 |
| 2018 | 0 | 8 | 8 |
| 2019 | 0 | 6 | 6 |
| 2020 | 0 | 9 | 9 |
| 2021 | 0 | 6 | 6 |
| 2022 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Enzyme Activation" by people in Profiles.
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Structural basis for mTORC1 activation on the lysosomal membrane. Nature. 2025 11; 647(8089):536-543.
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PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation. PLoS One. 2024; 19(9):e0306624.
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The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush. J Med Chem. 2022 11 10; 65(21):14289-14304.
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DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors. Proc Natl Acad Sci U S A. 2021 09 07; 118(36).
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Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells. Proc Natl Acad Sci U S A. 2021 06 22; 118(25).
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Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming. PLoS Biol. 2021 06; 19(6):e3001239.
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Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy. J Mol Cell Cardiol. 2021 09; 158:115-127.
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SMAC Mimetic/IAP Inhibitor Birinapant Enhances Radiosensitivity of Glioblastoma Multiforme. Radiat Res. 2021 06 01; 195(6):549-560.
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PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons. Neurochem Int. 2021 09; 148:105077.
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An Arabidopsis Oxalyl-CoA Decarboxylase, AtOXC, Is Important for Oxalate Catabolism in Plants. Int J Mol Sci. 2021 Mar 23; 22(6).