"Enzyme Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
| Descriptor ID |
D004789
|
| MeSH Number(s) |
G02.111.263 G03.328
|
| Concept/Terms |
Enzyme Activation- Enzyme Activation
- Activation, Enzyme
- Activations, Enzyme
- Enzyme Activations
|
Below are MeSH descriptors whose meaning is more general than "Enzyme Activation".
Below are MeSH descriptors whose meaning is more specific than "Enzyme Activation".
This graph shows the total number of publications written about "Enzyme Activation" by people in this website by year, and whether "Enzyme Activation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 19 | 20 |
| 1995 | 1 | 13 | 14 |
| 1996 | 0 | 29 | 29 |
| 1997 | 0 | 27 | 27 |
| 1998 | 0 | 41 | 41 |
| 1999 | 0 | 40 | 40 |
| 2000 | 1 | 53 | 54 |
| 2001 | 1 | 52 | 53 |
| 2002 | 0 | 70 | 70 |
| 2003 | 1 | 56 | 57 |
| 2004 | 1 | 63 | 64 |
| 2005 | 0 | 91 | 91 |
| 2006 | 0 | 68 | 68 |
| 2007 | 0 | 66 | 66 |
| 2008 | 0 | 65 | 65 |
| 2009 | 1 | 48 | 49 |
| 2010 | 1 | 49 | 50 |
| 2011 | 4 | 47 | 51 |
| 2012 | 0 | 47 | 47 |
| 2013 | 1 | 33 | 34 |
| 2014 | 1 | 28 | 29 |
| 2015 | 0 | 39 | 39 |
| 2016 | 0 | 20 | 20 |
| 2017 | 0 | 14 | 14 |
| 2018 | 0 | 15 | 15 |
| 2019 | 0 | 8 | 8 |
| 2020 | 0 | 12 | 12 |
| 2021 | 0 | 10 | 10 |
| 2022 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Enzyme Activation" by people in Profiles.
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PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation. PLoS One. 2024; 19(9):e0306624.
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The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush. J Med Chem. 2022 11 10; 65(21):14289-14304.
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Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in the C. elegans germline. Proc Natl Acad Sci U S A. 2022 01 18; 119(3).
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DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors. Proc Natl Acad Sci U S A. 2021 09 07; 118(36).
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Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 11; 161(5):1584-1600.
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Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3-amplified lung adenocarcinoma cells. Proc Natl Acad Sci U S A. 2021 06 22; 118(25).
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Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming. PLoS Biol. 2021 06; 19(6):e3001239.
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SMAC Mimetic/IAP Inhibitor Birinapant Enhances Radiosensitivity of Glioblastoma Multiforme. Radiat Res. 2021 06 01; 195(6):549-560.
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Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy. J Mol Cell Cardiol. 2021 09; 158:115-127.
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Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer. Elife. 2021 06 01; 10.