Amyloid beta-Protein Precursor
"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
| Descriptor ID |
D016564
|
| MeSH Number(s) |
D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
|
| Concept/Terms |
Amyloid beta-Protein Precursor- Amyloid beta-Protein Precursor
- Amyloid beta Protein Precursor
- beta-Protein Precursor, Amyloid
- Amyloid beta Precursor Protein
- Protease Nexin II
- Nexin II, Protease
- beta-Amyloid Protein Precursor
- beta Amyloid Protein Precursor
- Protease Nexin 2
- Nexin 2, Protease
- Amyloid A4 Protein Precursor
- Amyloid Protein Precursor
|
Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".
Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".
This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 3 | 3 |
| 2002 | 2 | 0 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 1 | 3 |
| 2006 | 3 | 1 | 4 |
| 2007 | 3 | 1 | 4 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 2 | 2 | 4 |
| 2011 | 5 | 0 | 5 |
| 2012 | 4 | 0 | 4 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 3 | 5 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 4 | 4 |
| 2017 | 1 | 2 | 3 |
| 2019 | 1 | 2 | 3 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 3 | 4 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 1 | 2 |
| 2025 | 1 | 1 | 2 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.
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Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model. Alzheimers Dement. 2025 03; 21(3):e70024.
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Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits. Nat Commun. 2019 01 04; 10(1):58.
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The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance. eNeuro. 2017 May-Jun; 4(3).
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NF?B-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease. Neuron. 2015 Jan 07; 85(1):101-115.
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The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function. PLoS One. 2011 Mar 22; 6(3):e18006.
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A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function. J Biol Chem. 2011 Mar 18; 286(11):8717-21.
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Regulation of cholesterol efflux by amyloid beta secretion. J Neurosci Res. 2010 Jul; 88(9):1985-94.
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Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J Neurosci. 2010 Feb 17; 30(7):2442-53.
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Increased asynchronous release and aberrant calcium channel activation in amyloid precursor protein deficient neuromuscular synapses. Neuroscience. 2007 Nov 23; 149(4):768-78.
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Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition. J Neurosci. 2006 Feb 01; 26(5):1386-95.