"Checkpoint Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzyme activated in response to DNA DAMAGE involved in cell cycle arrest. The gene is located on the long (q) arm of chromosome 22 at position 12.1. In humans it is encoded by the CHEK2 gene.
Descriptor ID |
D064447
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MeSH Number(s) |
D08.811.913.696.620.682.700.145
|
Concept/Terms |
Checkpoint Kinase 2- Checkpoint Kinase 2
- Kinase 2, Checkpoint
- Chk2 Protein Kinase
- Kinase, Chk2 Protein
- Protein Kinase, Chk2
- Checkpoint-Like Protein CHK2
- CHK2, Checkpoint-Like Protein
- Checkpoint Like Protein CHK2
- Protein CHK2, Checkpoint-Like
- Serine Threonine Protein Kinase Chk2
- LFS2 Protein Kinase
- Kinase, LFS2 Protein
- Protein Kinase, LFS2
- CHEK2 Kinase
- Kinase, CHEK2
- hCHK2 Kinase
- Kinase, hCHK2
- Serine-Threonine-Protein Kinase CHK2
- CHK2, Serine-Threonine-Protein Kinase
- Kinase CHK2, Serine-Threonine-Protein
- CDS1 Kinase
- Kinase, CDS1
- PP1425 Protein Kinase
- Kinase, PP1425 Protein
- Protein Kinase, PP1425
|
Below are MeSH descriptors whose meaning is more general than "Checkpoint Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "Checkpoint Kinase 2".
This graph shows the total number of publications written about "Checkpoint Kinase 2" by people in this website by year, and whether "Checkpoint Kinase 2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
1998 | 0 | 1 | 1 |
1999 | 0 | 3 | 3 |
2000 | 0 | 3 | 3 |
2001 | 0 | 3 | 3 |
2002 | 0 | 3 | 3 |
2003 | 0 | 11 | 11 |
2004 | 0 | 7 | 7 |
2005 | 0 | 4 | 4 |
2006 | 0 | 7 | 7 |
2007 | 0 | 3 | 3 |
2008 | 0 | 2 | 2 |
2009 | 0 | 6 | 6 |
2010 | 0 | 4 | 4 |
2011 | 0 | 2 | 2 |
2012 | 0 | 1 | 1 |
2013 | 1 | 2 | 3 |
2014 | 2 | 1 | 3 |
2015 | 3 | 1 | 4 |
2016 | 2 | 0 | 2 |
2017 | 1 | 3 | 4 |
2019 | 2 | 0 | 2 |
2020 | 2 | 0 | 2 |
2021 | 0 | 3 | 3 |
2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Checkpoint Kinase 2" by people in Profiles.
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ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk. Clin Cancer Res. 2023 08 15; 29(16):3037-3050.
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Genetic insights into biological mechanisms governing human ovarian ageing. Nature. 2021 08; 596(7872):393-397.
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Germline Predisposition to Prostate Cancer in Diverse Populations. Urol Clin North Am. 2021 Aug; 48(3):411-423.
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A phase 1 study of prexasertib (LY2606368), a CHK1/2 inhibitor, in pediatric patients with recurrent or refractory solid tumors, including CNS tumors: A report from the Children's Oncology Group Pediatric Early Phase Clinical Trials Network (ADVL1515). Pediatr Blood Cancer. 2021 09; 68(9):e29065.
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Radiation Treatment, ATM, BRCA1/2, and CHEK2*1100delC Pathogenic Variants and Risk of Contralateral Breast Cancer. J Natl Cancer Inst. 2020 12 14; 112(12):1275-1279.
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Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. J Clin Invest. 2020 11 02; 130(11):5951-5966.
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Assessing the performance of in silico methods for predicting the pathogenicity of variants in the gene CHEK2, among Hispanic females with breast cancer. Hum Mutat. 2019 09; 40(9):1612-1622.
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Identification of deleterious germline CHEK2 mutations and their association with breast and ovarian cancer. Int J Cancer. 2019 10 01; 145(7):1782-1797.
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Loss of MutL Disrupts CHK2-Dependent Cell-Cycle Control through CDK4/6 to Promote Intrinsic Endocrine Therapy Resistance in Primary Breast Cancer. Cancer Discov. 2017 10; 7(10):1168-1183.
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Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry. J Natl Cancer Inst. 2017 08 01; 109(8).