Homer Scaffolding Proteins
"Homer Scaffolding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1, Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis, whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells. Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signaling. They function as a molecular switch in metabotropic glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.
| Descriptor ID |
D000072233
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| MeSH Number(s) |
D12.776.476.024.381
|
| Concept/Terms |
Homer Scaffolding Proteins- Homer Scaffolding Proteins
- Proteins, Homer Scaffolding
- Scaffolding Proteins, Homer
- Homer Proteins
- Proteins, Homer
Homer 1C- Homer 1C
- Homer 1C Proteins
- Proteins, Homer 1C
Homer 3- Homer 3
- Homer 3 Proteins
- Proteins, Homer 3
Homer 2- Homer 2
- Homer 2 Proteins
- Proteins, Homer 2
Homer 1a- Homer 1a
- Homer 1 Proteins
- Proteins, Homer 1
|
Below are MeSH descriptors whose meaning is more general than "Homer Scaffolding Proteins".
Below are MeSH descriptors whose meaning is more specific than "Homer Scaffolding Proteins".
This graph shows the total number of publications written about "Homer Scaffolding Proteins" by people in this website by year, and whether "Homer Scaffolding Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Homer Scaffolding Proteins" by people in Profiles.
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Binge alcohol drinking by mice requires intact group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala. Neuropsychopharmacology. 2014 Jan; 39(2):435-44.
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Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet. 2011 Aug 01; 20(15):3093-108.
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Homer1 regulates the susceptibility to TRAIL. Exp Cell Res. 2009 Aug 01; 315(13):2249-55.
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Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance. J Neurosci. 2007 Apr 25; 27(17):4541-51.
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Gene profiling links SCA1 pathophysiology to glutamate signaling in Purkinje cells of transgenic mice. Hum Mol Genet. 2004 Oct 15; 13(20):2535-43.
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[Synaptic activity-dependent regulation of neuronal gene expression]. Tanpakushitsu Kakusan Koso. 2004 Feb; 49(3 Suppl):411-8.