"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015854
|
| MeSH Number(s) |
G02.111.905 G05.308.850 G07.690.773.998
|
| Concept/Terms |
Up-Regulation- Up-Regulation
- Up Regulation
- Upregulation
- Up-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Up-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".
This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 4 | 4 |
| 1997 | 0 | 4 | 4 |
| 1998 | 0 | 4 | 4 |
| 1999 | 1 | 5 | 6 |
| 2000 | 0 | 5 | 5 |
| 2001 | 0 | 7 | 7 |
| 2002 | 2 | 15 | 17 |
| 2003 | 1 | 28 | 29 |
| 2004 | 3 | 23 | 26 |
| 2005 | 3 | 30 | 33 |
| 2006 | 3 | 19 | 22 |
| 2007 | 1 | 16 | 17 |
| 2008 | 1 | 23 | 24 |
| 2009 | 3 | 28 | 31 |
| 2010 | 4 | 20 | 24 |
| 2011 | 3 | 41 | 44 |
| 2012 | 2 | 33 | 35 |
| 2013 | 1 | 26 | 27 |
| 2014 | 5 | 40 | 45 |
| 2015 | 6 | 24 | 30 |
| 2016 | 3 | 22 | 25 |
| 2017 | 5 | 22 | 27 |
| 2018 | 3 | 28 | 31 |
| 2019 | 1 | 26 | 27 |
| 2020 | 1 | 24 | 25 |
| 2021 | 1 | 9 | 10 |
| 2022 | 0 | 5 | 5 |
| 2023 | 0 | 3 | 3 |
| 2024 | 2 | 3 | 5 |
| 2025 | 0 | 4 | 4 |
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Below are the most recent publications written about "Up-Regulation" by people in Profiles.
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Deletion of Megalin in Kidney Tubular Epithelium Up-Regulates TGF?1 Signaling, Aggravates Ischemia/Reperfusion Kidney Injury, and Accelerates the Progression to Chronic Kidney Disease. Am J Pathol. 2026 Mar; 196(3):657-668.
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Aging Affects Lipid Homeostasis in Lacrimal Glands by Upregulating Lipogenesis and Changing Its Specificity. Invest Ophthalmol Vis Sci. 2025 Oct 01; 66(13):1.
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Lipoprotein(a) in pregnancy: A systematic review and meta-analysis. Prog Cardiovasc Dis. 2025 Sep-Oct; 92:161-179.
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Stress cardiovascular magnetic resonance imaging in intermediate-risk emergency department patients with abnormal high-sensitivity troponin. J Cardiovasc Magn Reson. 2025; 27(1):101851.
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P2X7R-primed keratinocytes are susceptible to apoptosis via GPCR-G??-pERK signal pathways. J Dermatol Sci. 2024 Dec; 116(3):90-99.
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A novel compound alleviates oxidative stress via PKA/CREB1-mediated DJ-1 upregulation. J Neurochem. 2024 09; 168(9):3034-3049.
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Organic light-emitting diode therapy promotes longevity through the upregulation of SIRT1 in senescence-accelerated mouse prone 8 mice. J Photochem Photobiol B. 2024 Aug; 257:112957.
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ANKRD1 expression is aberrantly upregulated in the mdm mouse model of muscular dystrophy and induced by stretch through NF?B. J Muscle Res Cell Motil. 2024 Dec; 45(4):191-200.
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AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Apr 12; 134(8):1006-1022.
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RNA-based translation activators for targeted gene upregulation. Nat Commun. 2023 10 26; 14(1):6827.