"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 5 | 7 |
| 2000 | 3 | 6 | 9 |
| 2001 | 1 | 5 | 6 |
| 2002 | 3 | 13 | 16 |
| 2003 | 0 | 13 | 13 |
| 2004 | 1 | 18 | 19 |
| 2005 | 2 | 25 | 27 |
| 2006 | 3 | 17 | 20 |
| 2007 | 5 | 13 | 18 |
| 2008 | 4 | 15 | 19 |
| 2009 | 3 | 18 | 21 |
| 2010 | 4 | 23 | 27 |
| 2011 | 4 | 32 | 36 |
| 2012 | 0 | 19 | 19 |
| 2013 | 1 | 17 | 18 |
| 2014 | 5 | 25 | 30 |
| 2015 | 1 | 20 | 21 |
| 2016 | 0 | 21 | 21 |
| 2017 | 6 | 18 | 24 |
| 2018 | 0 | 19 | 19 |
| 2019 | 2 | 18 | 20 |
| 2020 | 0 | 15 | 15 |
| 2021 | 1 | 6 | 7 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 3 | 3 |
| 2024 | 1 | 2 | 3 |
| 2025 | 0 | 3 | 3 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. Circ Res. 2023 06 23; 133(1):e1-e16.
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The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells. Dev Cell. 2021 04 19; 56(8):1100-1117.e9.
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EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization-promoting protein 1. FASEB J. 2020 12; 34(12):16205-16223.
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LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma. Mol Oncol. 2020 09; 14(9):2251-2270.
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Microscaled proteogenomic methods for precision oncology. Nat Commun. 2020 Jan 27; 11(1):532.
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Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant. Nat Commun. 2019 11 07; 10(1):5061.
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H22954, a novel long non-coding RNA down-regulated in AML, inhibits cancer growth in a BCL-2-dependent mechanism. Cancer Lett. 2019 07 10; 454:26-36.
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Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation. J Clin Invest. 2019 05 01; 129(5):1984-1999.
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Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer. Cancer Res. 2019 02 01; 79(3):518-533.
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Methylation of PCDH19 predicts poor prognosis of hepatocellular carcinoma. Asia Pac J Clin Oncol. 2018 Oct; 14(5):e352-e358.