"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.240 G05.308.200 G07.690.773.937
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 6 | 8 |
| 1995 | 3 | 5 | 8 |
| 1996 | 4 | 9 | 13 |
| 1997 | 0 | 14 | 14 |
| 1998 | 5 | 9 | 14 |
| 1999 | 3 | 20 | 23 |
| 2000 | 4 | 11 | 15 |
| 2001 | 5 | 17 | 22 |
| 2002 | 3 | 36 | 39 |
| 2003 | 9 | 61 | 70 |
| 2004 | 6 | 44 | 50 |
| 2005 | 5 | 83 | 88 |
| 2006 | 12 | 57 | 69 |
| 2007 | 10 | 52 | 62 |
| 2008 | 13 | 49 | 62 |
| 2009 | 7 | 59 | 66 |
| 2010 | 9 | 66 | 75 |
| 2011 | 10 | 61 | 71 |
| 2012 | 2 | 41 | 43 |
| 2013 | 7 | 45 | 52 |
| 2014 | 8 | 51 | 59 |
| 2015 | 5 | 33 | 38 |
| 2016 | 0 | 45 | 45 |
| 2017 | 7 | 34 | 41 |
| 2018 | 2 | 22 | 24 |
| 2019 | 3 | 31 | 34 |
| 2020 | 2 | 32 | 34 |
| 2021 | 5 | 10 | 15 |
| 2022 | 0 | 3 | 3 |
| 2023 | 0 | 7 | 7 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.
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Dominant negative variants in KIF5B cause osteogenesis imperfecta via down regulation of mTOR signaling. PLoS Genet. 2023 Nov; 19(11):e1011005.
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Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins. Cell Death Dis. 2023 11 02; 14(11):714.
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The synergy of the XPO1 inhibitors combined with the BET inhibitor INCB057643 in high-grade B-cell lymphoma via downregulation of MYC expression. Sci Rep. 2023 10 29; 13(1):18554.
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Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes. Cell Rep. 2023 10 31; 42(10):113148.
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The long non-coding RNA NEAT1 is a ?Np63 target gene modulating epidermal differentiation. Nat Commun. 2023 06 26; 14(1):3795.
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Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. Circ Res. 2023 06 23; 133(1):e1-e16.
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Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023 05; 617(7960):377-385.
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MGL S3 Chimeric Enzyme Drives Apoptotic Death of EGFR-Dependent Cancer Cells through ERK Downregulation. Int J Mol Sci. 2022 Oct 24; 23(21).
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HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression. J Zhejiang Univ Sci B. 2022 Aug 15; 23(8):666-681.
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Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure. J Biol Chem. 2022 05; 298(5):101816.