DNA (Cytosine-5-)-Methyltransferase 1
"DNA (Cytosine-5-)-Methyltransferase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.
| Descriptor ID |
D000076123
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| MeSH Number(s) |
D08.811.913.555.500.350.100.500.500 D12.776.157.687.313 D12.776.660.720.313
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA (Cytosine-5-)-Methyltransferase 1".
Below are MeSH descriptors whose meaning is more specific than "DNA (Cytosine-5-)-Methyltransferase 1".
This graph shows the total number of publications written about "DNA (Cytosine-5-)-Methyltransferase 1" by people in this website by year, and whether "DNA (Cytosine-5-)-Methyltransferase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2017 | 0 | 2 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA (Cytosine-5-)-Methyltransferase 1" by people in Profiles.
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UVB induces cutaneous squamous cell carcinoma progression by de novo ID4 methylation via methylation regulating enzymes. EBioMedicine. 2020 Jul; 57:102835.
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Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival. Int J Cancer. 2018 06 01; 142(11):2303-2312.
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The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer. Cell Rep. 2017 Dec 19; 21(12):3390-3397.
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Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer. Cancer Prev Res (Phila). 2017 Oct; 10(10):588-597.
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Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome. Genome Biol. 2015 Sep 30; 16:211.
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Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells. Genome Biol. 2015 Jun 02; 16:115.
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New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells. Exp Hematol. 2014 Aug; 42(8):609-17.
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Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 2013 Mar 18; 23(3):316-31.
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Conditional knockdown of DNA methyltransferase 1 reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis. Development. 2013 Mar; 140(6):1330-41.
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Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation. EMBO Rep. 2012 Dec; 13(12):1116-22.