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DEPINHO, RONALD A

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Item Type	Name
Academic Article	Comparative analysis of the expression and oncogenic activities of Xenopus c-, N-, and L-myc homologs.
Academic Article	Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.
Academic Article	Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells.
Academic Article	Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome.
Academic Article	Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development.
Academic Article	A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.
Academic Article	A genetic screen for candidate tumor suppressors identifies REST.
Academic Article	Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.
Academic Article	Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
Academic Article	International network of cancer genome projects.
Academic Article	SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.
Academic Article	Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.
Academic Article	Passenger deletions generate therapeutic vulnerabilities in cancer.
Academic Article	Proinvasion metastasis drivers in early-stage melanoma are oncogenes.
Concept	Genomic Library
Concept	Transgenes
Concept	Gene Rearrangement, T-Lymphocyte
Concept	Genes, Reporter
Concept	Gene Expression Regulation, Enzymologic
Concept	Gene Expression Profiling
Concept	Regulatory Elements, Transcriptional
Concept	Genes, erbB-2
Concept	Gene Amplification
Concept	Genes, cdc
Concept	Gene Regulatory Networks
Concept	Multigene Family
Concept	Genes, Tumor Suppressor
Concept	Oncogenes
Concept	Gene Expression
Concept	Open Reading Frames
Concept	Genes
Concept	Amino Acid Sequence
Concept	Gene Rearrangement, B-Lymphocyte, Heavy Chain
Concept	Catalytic Domain
Concept	Genes, p16
Concept	Genome, Human
Concept	Gene Targeting
Concept	Proto-Oncogenes
Concept	Genes, T-Cell Receptor beta
Concept	Gene Fusion
Concept	Gene Rearrangement
Concept	Lac Operon
Concept	Genes, Immunoglobulin
Concept	Genes, Essential
Concept	Genes, myc
Concept	Gene Expression Regulation, Neoplastic
Concept	Sequence Homology, Amino Acid
Concept	Sequence Homology, Nucleic Acid
Concept	Genome
Concept	Pseudogenes
Concept	Gene Rearrangement, B-Lymphocyte
Concept	Molecular Structure
Concept	Gene Deletion
Concept	Gene Silencing
Concept	Gene Duplication
Concept	Gene Knockout Techniques
Concept	Genes, erbB-1
Concept	Base Sequence
Concept	Alleles
Concept	Gene Knockdown Techniques
Concept	Genes, Homeobox
Concept	Gene Transfer Techniques
Concept	Molecular Sequence Data
Concept	Gene Expression Regulation, Developmental
Concept	Genes, Retinoblastoma
Concept	Conserved Sequence
Concept	Genes, ras
Concept	Repetitive Sequences, Nucleic Acid
Concept	Gene Expression Regulation
Concept	Consensus Sequence
Concept	Genes, Neoplasm
Concept	Chromosome Fragile Sites
Concept	Genes, p53
Concept	Genes, Immunoglobulin Light Chain
Concept	Gene Dosage
Academic Article	Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants.
Academic Article	Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver.
Academic Article	IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis.
Academic Article	Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53.
Academic Article	Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1.
Academic Article	Expression and activity of L-Myc in normal mouse development.
Academic Article	Cooperative effects of INK4a and ras in melanoma susceptibility in vivo.
Academic Article	A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.
Academic Article	DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation.
Academic Article	Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.
Academic Article	Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Academic Article	Constitutive telomerase expression promotes mammary carcinomas in aging mice.
Academic Article	Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells.
Academic Article	The LKB1 tumor suppressor negatively regulates mTOR signaling.
Academic Article	Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.
Academic Article	High-resolution genomic profiles of human lung cancer.
Academic Article	Common and contrasting genomic profiles among the major human lung cancer subtypes.
Academic Article	Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities.
Academic Article	Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.
Academic Article	Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.
Academic Article	HDAC2 negatively regulates memory formation and synaptic plasticity.
Academic Article	Somatic p16(INK4a) loss accelerates melanomagenesis.
Academic Article	FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis.
Academic Article	Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia.
Academic Article	Survival factor NFIL3 restricts FOXO-induced gene expression in cancer.
Academic Article	Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle.
Academic Article	Instability of immunoglobulin genes in S107 cell line.
Academic Article	IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.
Academic Article	Structure and expression of the murine L-myc gene.
Academic Article	Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype.
Academic Article	p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
Academic Article	Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer.
Academic Article	Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.
Academic Article	The INK4a/ARF tumor suppressor: one gene--two products--two pathways.
Academic Article	p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation.
Academic Article	The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.
Academic Article	Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc.
Academic Article	Essential role for Max in early embryonic growth and development.
Academic Article	Overexpression of Mad transcription factor inhibits proliferation of cultured human hepatocellular carcinoma cells along with tumor formation in immunodeficient animals.
Academic Article	Animal models of melanoma: recent advances and future prospects.
Academic Article	DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.
Academic Article	Hepatocyte transplantation improves survival in mice with liver toxicity induced by hepatic overexpression of Mad1 transcription factor.
Academic Article	Tetracycline-inducible system for photoreceptor-specific gene expression.
Academic Article	Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility.
Academic Article	Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.
Academic Article	Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame.
Academic Article	Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression.
Academic Article	Genetic determinants of malignancy in a mouse model for oligodendroglioma.
Academic Article	Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a.
Academic Article	mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells.
Academic Article	Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.
Academic Article	Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination.
Academic Article	Molecular diversity of astrocytes with implications for neurological disorders.
Academic Article	High-resolution characterization of the pancreatic adenocarcinoma genome.
Academic Article	Cancer: crime and punishment.
Academic Article	Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
Academic Article	Characterization of melanocyte-specific inducible Cre recombinase transgenic mice.
Academic Article	Malignant astrocytic glioma: genetics, biology, and paths to treatment.
Academic Article	Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.
Academic Article	Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
Academic Article	Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation.
Academic Article	Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16.
Academic Article	Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.
Academic Article	Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice.
Academic Article	FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation.
Academic Article	Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.
Academic Article	FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
Academic Article	FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts.
Academic Article	Mig-6 controls EGFR trafficking and suppresses gliomagenesis.
Academic Article	Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells.
Academic Article	Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.
Academic Article	Towards patient-based cancer therapeutics.
Academic Article	Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor.
Academic Article	A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis.
Academic Article	Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma.
Academic Article	Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
Academic Article	Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis.
Academic Article	PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
Academic Article	Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
Academic Article	Structural and functional analysis of the mouse mdr1b gene promoter.
Academic Article	The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression.
Academic Article	Differential regulation of the N-myc gene in transfected cells and transgenic mice.
Academic Article	Myc family of cellular oncogenes.
Academic Article	Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice.
Academic Article	The human myc gene family: structure and activity of L-myc and an L-myc pseudogene.
Academic Article	A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes.
Academic Article	Myc family genes: a dispersed multi-gene family.
Academic Article	Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells.
Academic Article	Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene.
Academic Article	Inhibition of ras-induced proliferation and cellular transformation by p16INK4.
Academic Article	Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.
Academic Article	Role of first exon/intron sequences in the regulation of myc family oncogenic potency.
Academic Article	Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution.
Academic Article	Role of the INK4a locus in tumor suppression and cell mortality.
Academic Article	Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype.
Academic Article	Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.
Academic Article	The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
Academic Article	Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation.
Academic Article	Repression by the Mad(Mxi1)-Sin3 complex.
Academic Article	Malignant melanoma: modern black plague and genetic black box.
Academic Article	Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.
Academic Article	The INK4A/ARF locus and its two gene products.
Academic Article	Essential role for oncogenic Ras in tumour maintenance.
Academic Article	Gene-target recognition among members of the myc superfamily and implications for oncogenesis.
Academic Article	Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice.
Academic Article	Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.
Academic Article	N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.
Academic Article	Mice without telomerase: what can they teach us about human cancer?
Academic Article	Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.
Academic Article	Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.
Academic Article	Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.
Academic Article	Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.
Academic Article	The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.
Academic Article	Conquering the complexity of p53.
Academic Article	Telomeres, stem cells, senescence, and cancer.
Academic Article	Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.
Academic Article	Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF.
Academic Article	How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer.
Academic Article	Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development.
Academic Article	mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.
Academic Article	Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.
Academic Article	Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.
Academic Article	The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Academic Article	Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Academic Article	High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients.
Academic Article	Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression.
Academic Article	FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription.
Academic Article	FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Academic Article	FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Academic Article	Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.
Academic Article	Alu elements mediate MYB gene tandem duplication in human T-ALL.
Academic Article	Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.
Academic Article	SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway.
Academic Article	Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.
Academic Article	The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.
Academic Article	Foxo1 integrates insulin signaling with mitochondrial function in the liver.
Academic Article	FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.
Academic Article	Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.
Academic Article	Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene.
Academic Article	PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-?B-cytokine network.
Academic Article	Emerging insights into the molecular and cellular basis of glioblastoma.
Academic Article	The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism.
Academic Article	Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6.
Academic Article	From the Cover: Neutralization of terminal differentiation in gliomagenesis.
Academic Article	Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Academic Article	Dual inactivation of RB and p53 pathways in RAS-induced melanomas.
Academic Article	Take care of your chromosomes lest cancer take care of you.
Academic Article	Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus.
Academic Article	Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
Academic Article	PTEN: a novel anti-oncogenic function independent of phosphatase activity.
Academic Article	Genetics and biology of pancreatic ductal adenocarcinoma.
Academic Article	Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
Academic Article	Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells.
Academic Article	Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway.
Academic Article	p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.
Academic Article	Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.
Academic Article	Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma.
Academic Article	Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells.
Academic Article	Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.
Academic Article	Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice.
Academic Article	IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.
Academic Article	STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.
Academic Article	FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression.
Academic Article	mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.
Academic Article	A biochemical and biological analysis of Myc superfamily interactions.
Academic Article	Transcriptional repression. The cancer-chromatin connection.
Academic Article	A bumper crop of cancer genes.
Academic Article	Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery.
Academic Article	Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice.
Academic Article	The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.
Academic Article	Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations.
Academic Article	A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma.
Academic Article	Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.
Academic Article	A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.
Academic Article	Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.
Academic Article	Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.
Academic Article	FOXO1 in the ventromedial hypothalamus regulates energy balance.
Academic Article	FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin.
Academic Article	Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis.
Academic Article	Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.
Academic Article	Telomere dysfunction suppresses multiple endocrine neoplasia in mice.
Academic Article	Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy.
Academic Article	FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization.
Academic Article	Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth.
Academic Article	Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma.
Academic Article	Genetics and biology of pancreatic ductal adenocarcinoma
Academic Article	Erratum
Academic Article	Erratum
Academic Article	Telomere dysfunction suppresses multiple endocrine Neoplasia in mice
Academic Article	PRKCI promotes immune suppression in ovarian cancer.
Academic Article	Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation.
Academic Article	Genetics and biology of pancreatic ductal adenocarcinoma.
Academic Article	Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.
Academic Article	Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.
Academic Article	Oncogenic Kras drives invasion and maintains metastases in colorectal cancer.
Academic Article	Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.
Academic Article	Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.
Academic Article	PAF promotes stemness and radioresistance of glioma stem cells.
Academic Article	Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Academic Article	Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Academic Article	FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.
Academic Article	Opposing roles of TGF? and BMP signaling in prostate cancer development.
Academic Article	STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers.
Academic Article	Genetics and biology of prostate cancer.
Academic Article	An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer.
Academic Article	KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
Academic Article	Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.
Concept	Gene Editing
Concept	Transcriptome
Academic Article	Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma.
Academic Article	USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.
Academic Article	Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment.
Academic Article	Programmable base editing of mutated TERT promoter inhibits brain tumour growth.
Academic Article	Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer.
Academic Article	FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.
Academic Article	Single-cell RNA sequencing in pancreatic cancer.
Academic Article	Genetic and biological hallmarks of colorectal cancer.
Academic Article	USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer.
Academic Article	Drivers of transcriptional variance in human intestinal epithelial organoids.
Academic Article	Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer.
Academic Article	Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer.
Academic Article	Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer.

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