"Genes, p16" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies. (From Segen, Current Med Talk, 1995) Two alternatively spliced gene products are encoded by p16: CYCLIN-DEPENDENT KINASE INHIBITOR P16 and TUMOR SUPPRESSOR PROTEIN P14ARF.
| Descriptor ID |
D019942
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.375 G05.360.340.024.340.415.400.375
|
| Concept/Terms |
Genes, p16- Genes, p16
- Genes, CDKN2
- Genes, CDKN2A
- CDKN2A Gene
- CDKN2A Genes
- Genes, MTS1
- MTS1 Gene
- Genes, p16INK4A
- p16INK4A Gene
- p16INK4A Genes
- p16 Genes
- p16 Gene
- Genes, p16INK4
- p16INK4 Gene
- p16INK4 Genes
- CDKN2 Genes
- CDKN2 Gene
- MTS1 Genes
|
Below are MeSH descriptors whose meaning is more general than "Genes, p16".
Below are MeSH descriptors whose meaning is more specific than "Genes, p16".
This graph shows the total number of publications written about "Genes, p16" by people in this website by year, and whether "Genes, p16" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genes, p16" by people in Profiles.
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Glioma progression is shaped by genetic evolution and microenvironment interactions. Cell. 2022 06 09; 185(12):2184-2199.e16.
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Melanoma-specific expression of the tumor suppressor proteins p16 and PTEN is a favorable prognostic factor in established melanoma brain metastases. Melanoma Res. 2021 06 01; 31(3):264-267.
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Relationships between highly recurrent tumor suppressor alterations in 489 leiomyosarcomas. Cancer. 2021 08 01; 127(15):2666-2673.
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Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children. J Natl Cancer Inst. 2019 12 01; 111(12):1350-1357.
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Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus. Oral Oncol. 2016 May; 56:47-53.
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Comprehensive genomic profiling of 295 cases of clinically advanced urothelial carcinoma of the urinary bladder reveals a high frequency of clinically relevant genomic alterations. Cancer. 2016 Mar 01; 122(5):702-11.
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Characterization of Clinical Cases of Collecting Duct Carcinoma of the Kidney Assessed by Comprehensive Genomic Profiling. Eur Urol. 2016 09; 70(3):516-21.
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Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome. Blood. 2013 Oct 10; 122(15):2673-82.
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Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012 Sep 27; 489(7417):519-25.
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Survey of familial glioma and role of germline p16INK4A/p14ARF and p53 mutation. Fam Cancer. 2010 Sep; 9(3):413-21.