"Genes, p16" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies. (From Segen, Current Med Talk, 1995) Two alternatively spliced gene products are encoded by p16: CYCLIN-DEPENDENT KINASE INHIBITOR P16 and TUMOR SUPPRESSOR PROTEIN P14ARF.
| Descriptor ID |
D019942
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.375 G05.360.340.024.340.415.400.375
|
| Concept/Terms |
Genes, p16- Genes, p16
- Genes, CDKN2
- Genes, CDKN2A
- CDKN2A Gene
- CDKN2A Genes
- Genes, MTS1
- MTS1 Gene
- Genes, p16INK4A
- p16INK4A Gene
- p16INK4A Genes
- p16 Genes
- p16 Gene
- Genes, p16INK4
- p16INK4 Gene
- p16INK4 Genes
- CDKN2 Genes
- CDKN2 Gene
- MTS1 Genes
|
Below are MeSH descriptors whose meaning is more general than "Genes, p16".
Below are MeSH descriptors whose meaning is more specific than "Genes, p16".
This graph shows the total number of publications written about "Genes, p16" by people in this website by year, and whether "Genes, p16" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genes, p16" by people in Profiles.
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Melanoma-specific expression of the tumor suppressor proteins p16 and PTEN is a favorable prognostic factor in established melanoma brain metastases. Melanoma Res. 2021 06 01; 31(3):264-267.
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Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children. J Natl Cancer Inst. 2019 12 01; 111(12):1350-1357.
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Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus. Oral Oncol. 2016 May; 56:47-53.
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Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012 Sep 27; 489(7417):519-25.
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Survey of familial glioma and role of germline p16INK4A/p14ARF and p53 mutation. Fam Cancer. 2010 Sep; 9(3):413-21.
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Estimating CDKN2A carrier probability and personalizing cancer risk assessments in hereditary melanoma using MelaPRO. Cancer Res. 2010 Jan 15; 70(2):552-9.
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Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science. 2008 Nov 28; 322(5906):1377-80.
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Oral epithelium as a surrogate tissue for assessing smoking-induced molecular alterations in the lungs. Cancer Prev Res (Phila). 2008 Jun; 1(1):39-44.
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Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst. 2007 Sep 19; 99(18):1410-4.
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Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging Cell. 2007 Aug; 6(4):577-91.