"Genes, BRCA2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)
| Descriptor ID |
D024522
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| MeSH Number(s) |
G05.360.340.024.340.375.249.105 G05.360.340.024.340.415.400.105
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Genes, BRCA2".
Below are MeSH descriptors whose meaning is more specific than "Genes, BRCA2".
This graph shows the total number of publications written about "Genes, BRCA2" by people in this website by year, and whether "Genes, BRCA2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, BRCA2" by people in Profiles.
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Clinical Trial in Progress: SWOG S2210, a Phase 2 Study of Neoadjuvant Carboplatin for Localized High-risk Prostate Cancer with Germline BRCA1/2 Mutations. Eur Urol Focus. 2026 Jan; 12(1):16-18.
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Association of Inherited Mutations in DNA Repair Genes with Localized Prostate Cancer. Eur Urol. 2022 06; 81(6):559-567.
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Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 01 06; 19(1):77-102.
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Anti-M?llerian Hormone (AMH) regulates BRCA1 and BRCA2 gene expression after ovarian cortex transplantation. Gynecol Endocrinol. 2021 Apr; 37(4):349-352.
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Exome sequencing and characterization of 49,960 individuals in the UK Biobank. Nature. 2020 10; 586(7831):749-756.
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Returning a Genomic Result for an Adult-Onset Condition to the Parents of a Newborn: Insights From the BabySeq Project. Pediatrics. 2019 01; 143(Suppl 1):S37-S43.
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BRCA Challenge: BRCA Exchange as a global resource for variants in BRCA1 and BRCA2. PLoS Genet. 2018 12; 14(12):e1007752.
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Authors' Response: "Angelina Jolie Effect" on the Shifting Role of BRCA Testing in the U.S. Am J Prev Med. 2017 11; 53(5):e197-e199.
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Myriad take two: Can genomic databases remain secret? Science. 2017 05 12; 356(6338):586-587.
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Use of BRCA Mutation Test in the U.S., 2004-2014. Am J Prev Med. 2017 Jun; 52(6):702-709.