"Genes, BRCA2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)
| Descriptor ID |
D024522
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.105 G05.360.340.024.340.415.400.105
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Genes, BRCA2".
Below are MeSH descriptors whose meaning is more specific than "Genes, BRCA2".
This graph shows the total number of publications written about "Genes, BRCA2" by people in this website by year, and whether "Genes, BRCA2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2001 | 2 | 2 | 4 |
| 2002 | 6 | 5 | 11 |
| 2003 | 3 | 4 | 7 |
| 2004 | 2 | 2 | 4 |
| 2005 | 0 | 2 | 2 |
| 2006 | 2 | 4 | 6 |
| 2007 | 7 | 4 | 11 |
| 2008 | 2 | 4 | 6 |
| 2009 | 2 | 2 | 4 |
| 2010 | 6 | 5 | 11 |
| 2011 | 11 | 3 | 14 |
| 2012 | 4 | 3 | 7 |
| 2013 | 2 | 2 | 4 |
| 2014 | 8 | 2 | 10 |
| 2015 | 4 | 6 | 10 |
| 2016 | 7 | 4 | 11 |
| 2017 | 7 | 3 | 10 |
| 2018 | 2 | 6 | 8 |
| 2019 | 3 | 3 | 6 |
| 2020 | 4 | 5 | 9 |
| 2021 | 1 | 8 | 9 |
| 2024 | 0 | 2 | 2 |
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Below are the most recent publications written about "Genes, BRCA2" by people in Profiles.
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BRCA-mutated breast cancer: the unmet need, challenges and therapeutic benefits of genetic testing. Br J Cancer. 2024 Nov; 131(9):1400-1414.
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Hereditary Breast Cancer: BRCA Mutations and Beyond. Radiol Clin North Am. 2024 Jul; 62(4):627-642.
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Germline mutations in penetrant cancer predisposition genes are rare in men with prostate cancer selecting active surveillance. Cancer Med. 2022 11; 11(22):4332-4340.
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Impact of veliparib, paclitaxel dosing regimen, and germline BRCA status on the primary treatment of serous ovarian cancer - an ancillary data analysis of the VELIA trial. Gynecol Oncol. 2022 02; 164(2):278-287.
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Impact of homologous recombination status and responses with veliparib combined with first-line chemotherapy in ovarian cancer in the Phase 3 VELIA/GOG-3005 study. Gynecol Oncol. 2022 02; 164(2):245-253.
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Breast Radiation Therapy-Related Treatment Outcomes in Patients With or Without Germline Mutations on Multigene Panel Testing. Int J Radiat Oncol Biol Phys. 2022 02 01; 112(2):437-444.
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Increasing referral of at-risk women for genetic counseling and BRCA testing using a screening tool in a community breast imaging center. Cancer. 2022 Jan 01; 128(1):94-102.
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Risk factors for progression or death after first-line platinum-based chemotherapy in real-world patients in the?USA with ovarian cancer from 2011 to 2018. Future Oncol. 2021 Nov; 17(32):4263-4274.
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Efficacy and safety of first-line veliparib and carboplatin-paclitaxel in patients with HER2- advanced germline BRCA+ breast cancer: Subgroup analysis of a randomised clinical trial. Eur J Cancer. 2021 09; 154:35-45.
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Hereditary ovarian tumour syndromes: current update on genetics and imaging. Clin Radiol. 2021 Apr; 76(4):313.e15-313.e26.