"Genes, Retinoblastoma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.
| Descriptor ID |
D016161
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.400 G05.360.340.024.340.415.400.400
|
| Concept/Terms |
Genes, Retinoblastoma- Genes, Retinoblastoma
- Rb Genes
- Retinoblastoma Genes
- Gene, Retinoblastoma
- Retinoblastoma Gene
- Genes, Rb
- Gene, Rb
- Rb Gene
|
Below are MeSH descriptors whose meaning is more general than "Genes, Retinoblastoma".
Below are MeSH descriptors whose meaning is more specific than "Genes, Retinoblastoma".
This graph shows the total number of publications written about "Genes, Retinoblastoma" by people in this website by year, and whether "Genes, Retinoblastoma" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 2 | 3 |
| 1999 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, Retinoblastoma" by people in Profiles.
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Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies. Proc Natl Acad Sci U S A. 2022 04 19; 119(16):e2117857119.
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A gene expression signature of Retinoblastoma loss-of-function predicts resistance to neoadjuvant chemotherapy in ER-positive/HER2-positive breast cancer patients. Breast Cancer Res Treat. 2018 Jul; 170(2):329-341.
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Next-generation sequencing-based method shows increased mutation detection sensitivity in an Indian retinoblastoma cohort. Mol Vis. 2016; 22:1036-47.
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Tumorspheres but not adherent cells derived from retinoblastoma tumors are of malignant origin. PLoS One. 2013; 8(6):e63519.
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Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. J Exp Med. 2013 Jun 03; 210(6):1087-97.
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Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17531-6.
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Outcomes of integrating genetics in management of patients with retinoblastoma. Arch Ophthalmol. 2011 Nov; 129(11):1428-34.
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Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. Cancer Cell. 2011 Feb 15; 19(2):177-91.
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Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice. Carcinogenesis. 2009 Oct; 30(10):1789-95.
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Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity. Cancer Gene Ther. 2009 Mar; 16(3):256-65.